Arroyo Seco II offers a rare genetic window into Early Holocene South America: five genome or uniparental samples (sample count = 5) have yielded consistent signals that tie the site to pan‑American founding lineages. On the paternal side, four of the five sampled males carry Y‑DNA haplogroup Q — a lineage widely reported across the Americas and commonly interpreted as part of the primary male founder spectrum. This predominance of Q in a small sample could reflect local male continuity or sampling bias; with fewer than ten individuals, any demographic inference is provisional.
Mitochondrial DNA among the Arroyo Seco II individuals is diverse: two C1b, one D1, one A2, and one D1g. These maternal haplogroups belong to the recognized set of founding Native American mtDNA clades (A2, B2, C1, D1, and their subclades). The mixture of C1b and D1 lineages at the site aligns with broader South American patterns where C and D derivatives are common, while A2 appears more sporadically but is part of the founding maternal pool. Together, the uniparental picture suggests a community that both shares continental founder ancestry and preserves maternal diversity.
When combined with archaeological context — burial placement, artifact types, and mobility indicators — the genetic data support a scenario of Early Holocene inhabitants in the Pampas with deep roots in the founding populations of South America. However, given the very small sample size, statements about population structure, sex‑biased migration, or long‑term continuity must remain guarded. Expanded sampling and genome‑wide analyses will be necessary to move from promising hypotheses to robust conclusions.