Active: Healthy aging Clear all

GWAS 2025-10-01

A genome-wide association study identified 10 novel genomic loci associated with intrinsic capacity.

Beyene MB, Visvanathan R et al.

J Gerontol A Biol Sci Med Sci

Intrinsic capacity (IC) is a multidimensional concept within the World Health Organization framework...

Intrinsic capacity

44631

Participants

N/A

Studies

Details PubMed

GWAS 2023-08-07

Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging.

Rosoff DB, Mavromatis LA et al.

Nat Aging

The concept of aging is complex, including many related phenotypes such as healthspan, lifespan, ext...

Aging

1559001

Participants

N/A

Studies

Details PubMed

GWAS 2022-05-02

Genetic associations with healthy ageing among Chinese adults.

Chang X, Zhou YF et al.

NPJ Aging

The genetic basis of overall healthy ageing, especially among the East-Asian population is understud...

Healthy aging

Replicated

7839

Participants

N/A

Studies

Details PubMed

GWAS 2022-04-14

Metagenomic and metabolomic remodeling in nonagenarians and centenarians and its association with genetic and socioeconomic factors.

Xu Q, Wu C et al.

Nat Aging

A better understanding of the biological and environmental variables that contribute to exceptional ...

1-(1-enyl-palmitoyl)-2-arachidonoyl-gpc (p-16:0/20:4) levels (advanced age)

116

Participants

N/A

Studies

Details PubMed

GWAS 2020-02-14

Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies.

Feitosa MF, Lunetta KL et al.

Atherosclerosis

Backgrounds and aims: Several genes are known to contribute to the levels and metabolism of HDL-C, h...

HDL cholesterol levels

7738

Participants

N/A

Studies

Details PubMed

GWAS 2019-07-29

LRRTM4 and PCSK5 Genetic Polymorphisms as Markers for Cognitive Impairment in A Hypotensive Aging Population: A Genome-Wide Association Study in Taiwan.

Chen YC, Liu YL et al.

J Clin Med

Hypotension can affect cerebral perfusion and worsen cognitive outcomes. The prevalence of low blood...

Hypotension and cognitive impairment

1855

Participants

N/A

Studies

Details PubMed

GWAS 2017-07-19

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Zillikens MC, Demissie S et al.

Nat Commun

Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a...

Appendicular lean mass

Replicated

73420

Participants

N/A

Studies

Details PubMed

GWAS 2014-09-15

Genome-wide admixture and association study of serum iron, ferritin, transferrin saturation and total iron binding capacity in African Americans.

Li J, Lange LA et al.

Hum Mol Genet

Iron is an essential component of many important proteins and enzymes, including hemoglobin, which i...

Iron status biomarkers

Replicated

2676

Participants

N/A

Studies

Details PubMed

GWAS 2014-03-11

Heritability and genetic association analysis of cognition in the Diabetes Heart Study.

Cox AJ, Hugenschmidt CE et al.

Neurobiol Aging

Cognitive performance is an important component of healthy aging. Type 2 diabetes (T2D) is associate...

Cognitive function

550

Participants

N/A

Studies

Details PubMed

GWAS 2013-12-04

Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c) levels in non-diabetic subjects: the Long Life Family Study (LLFS).

An P, Miljkovic I et al.

Metabolism

Objective: Glycated hemoglobin (HbA1c) is a stable index of chronic glycemic status and hyperglycemi...

Glycated hemoglobin levels

Replicated

51910

Participants

N/A

Studies

Details PubMed

GWAS 2013-05-08

Genome-wide association study of personality traits in the long life family study.

Bae HT, Sebastiani P et al.

Front Genet

Personality traits have been shown to be associated with longevity and healthy aging. In order to di...

Personality dimensions

Replicated

5002

Participants

N/A

Studies

Details PubMed

GWAS 2011-07-20

A genome-wide association study of aging.

Walter S, Atzmon G et al.

Neurobiol Aging

Human longevity and healthy aging show moderate heritability (20%-50%). We conducted a meta-analysis...

Aging (time to death)

Replicated

35418

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

A genome-wide association study identified 10 novel genomic loci associated with intrinsic capacity.

Beyene MB, Visvanathan R et al.

J Gerontol A Biol Sci Med Sci

Intrinsic capacity

2025-10-01

Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging.

Rosoff DB, Mavromatis LA et al.

Nat Aging

Aging

2023-08-07

Genetic associations with healthy ageing among Chinese adults.

Chang X, Zhou YF et al.

NPJ Aging

Healthy aging

2022-05-02

Metagenomic and metabolomic remodeling in nonagenarians and centenarians and its association with genetic and socioeconomic factors.

Xu Q, Wu C et al.

Nat Aging

1-(1-enyl-palmitoyl)-2-arachidonoyl-gpc (p-16:0/20:4) levels (advanced age)

2022-04-14

Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies.

Feitosa MF, Lunetta KL et al.

Atherosclerosis

HDL cholesterol levels

2020-02-14

LRRTM4 and PCSK5 Genetic Polymorphisms as Markers for Cognitive Impairment in A Hypotensive Aging Population: A Genome-Wide Association Study in Taiwan.

Chen YC, Liu YL et al.

J Clin Med

Hypotension and cognitive impairment

2019-07-29

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Zillikens MC, Demissie S et al.

Nat Commun

Appendicular lean mass

2017-07-19

Genome-wide admixture and association study of serum iron, ferritin, transferrin saturation and total iron binding capacity in African Americans.

Li J, Lange LA et al.

Hum Mol Genet

Iron status biomarkers

2014-09-15

Heritability and genetic association analysis of cognition in the Diabetes Heart Study.

Cox AJ, Hugenschmidt CE et al.

Neurobiol Aging

Cognitive function

2014-03-11

Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c) levels in non-diabetic subjects: the Long Life Family Study (LLFS).

An P, Miljkovic I et al.

Metabolism

Glycated hemoglobin levels

2013-12-04

Genome-wide association study of personality traits in the long life family study.

Bae HT, Sebastiani P et al.

Front Genet

Personality dimensions

2013-05-08

A genome-wide association study of aging.

Walter S, Atzmon G et al.

Neurobiol Aging

Aging (time to death)

2011-07-20