Ancestry Publications

Yao Yu, Xiaoguang Zhu, Hailiang Meng et al.

Journal of Genetics and Genomics

China

Singh Vanya, V Basu Mallick, Chandana C et al.

American journal of human biology : the official journal of the Human Biology CouncilAm J Hum BiolAdmixture and Genetic Connectivity: Autosomal Insights Into Indo-Aryan Speakers at the Eastern Edge of the Indian Subcontinent.e70245e7024510.1002/ajhb.70245Assam serves as a melting pot where various ethnicities converge, shaped by its strategic location bordering the six northeastern states and neighboring countries. This study examines the genomic ancestry of Indo-Aryan speakers in Assam, a region at the eastern edge of the Indian subcontinent known for its diverse linguistic and cultural influences. Principal Components Analysis (PCA) revealed that Assamese Indo-Aryans cluster closely with Bangladeshi Indo-Aryans, diverging from the typical South Asian genetic continuum. This group shows significant ancestral influences from East and Southeast Asia. Outgroup f3 statistics indicated that Assamese Indo-Aryans exhibit greater genetic drift in relation to other Indo-Aryan populations, particularly the Harijan and Kol groups from the Ganga plain, rather than with geographically closer Bengali or Nyishi populations. Haplotype-based fine-structure and identity by descent (IBD) analyses confirmed a close genetic affinity with Bangladeshi Indo-Aryans, along with notable connections to Harijan and Kol populations. The low levels of Runs of Homozygosity (RoH) suggest a high degree of genetic diversity, most likely due to a result of admixture and a large effective population size. Admixture events are estimated to have occurred 55 to 61 generations ago, indicating a composition of 76% Indian ancestry and 24% East/Southeast Asian ancestry. These findings, with enhanced resolution, suggest a reconsideration of the previous assumption that Northeast India served as a genetic barrier. Instead, they appear to support its role as a corridor facilitating bidirectional gene flow between South and East/Southeast Asia. Furthermore, the coexistence of diverse linguistic affiliations of ethnic groups in this region reflects in their ancestry patterns. These findings highlight the complex interplay of geography, language, and genetic exchange in the region.© 2026 Wiley Periodicals LLC.SinghVanyaV0000-0002-2832-7393Gyan Lab, Cytogenetics Unit, Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India.Basu MallickChandanaC0000-0001-9459-2710Centre for Genetic Disorders, Banaras Hindu University, Varanasi, Uttar Pradesh, India.ChatterjeeMadhumatiM0000-0002-0136-6149Department of Anthropology, Dr APJ Abdul Kalam Government College, Kolkata, India.TamangRakeshR0000-0001-9873-3066Department of Zoology, University of Calcutta, Kolkata, West Bengal, India.DesaiShaileshS0000-0002-1812-5106Gyan Lab, Cytogenetics Unit, Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India.SinghPrajjval PratapPP0000-0002-8081-5634Laboratory of Genomics and Profiling Applications, BRIC-Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India.MishraRahul KumarRK0000-0003-2608-7856Gyan Lab, Cytogenetics Unit, Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India.Amity Institute of Biotechnology, Amity University Chhattisgarh, Raipur, India.PandeyRudra KumarRK0000-0002-0995-923XGyan Lab, Cytogenetics Unit, Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India.MishraRitushaR0000-0003-4533-0727Department of Radiotherapy and Radiation Medicines, Banaras Hindu University, Varanasi, Uttar Pradesh, India.SinghAshishA0000-0002-6819-2905Dr. Lalji Singh Research Centre, Kalwari, Jaunpur, Uttar Pradesh, India.SuravajhalaPrashanthP0000-0002-8535-278XDepartment of Biosciences, Manipal University Jaipur, Jaipur, Rajasthan, India.BandyopadhyayArup RatanAR0000-0003-3119-0022Department of Anthropology, University of Calcutta, Kolkata, West Bengal, India.ChaubeyGyaneshwerG0000-0003-2899-3852Gyan Lab, Cytogenetics Unit, Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India.eng6031BHU IoE incentive grant BHU2021-6389Indian Council of Medical Research2021-11289Indian Council of Medical ResearchDepartment of Zoology, BHUJournal ArticleUnited StatesAm J Hum Biol89150291042-0533IMHumansIndiaHaplotypesGene FlowPrincipal Component AnalysisGenetic VariationEthnicitygeneticsGenetics, PopulationAsian PeoplegeneticsIndo‐AryanNortheast IndiaTibeto‐Burmanadmixtureautosomesgeneflow20263520251062026310202632071120263207102026320213ppublish4185809810.1002/ajhb.70245References

India

Jiang Xiucheng, X Chen, Cui C et al.

BMC genomics

Cai Meiming, M Shen, Ruonan R et al.

BMC genomics

Bangyan Wang, Rui Wang, Duo Zheng et al.

Journal of Genetics and Genomics

China

Casas-Vargas Andrea, A Guzmán, Alejandra Coronel AC et al.

American journal of human biology : the official journal of the Human Biology CouncilAm J Hum BiolGenetic Structure of the Y-Chromosome in Colombia: An Analysis of Regional Diversity and Ancestry.e70171e7017110.1002/ajhb.70171To determine the genetic diversity and ancestry of male lineages across various regions of Colombia by analyzing Y-chromosome Short Tandem Repeats (STRs) and to explore how these genetic variations relate to the historical and migratory events that shaped the country's subpopulations.A total of 672 DNA samples from diverse Colombian populations were analyzed, and Y-chromosome STRs were genotyped using the Yfiler and Yfiler Plus amplification kits. Haplogroup assignments were performed using open-source software, and multivariate analyses were employed to facilitate intra- and interpopulation comparisons.Substantial genetic diversity was observed among the haplotypes of the studied populations. Haplogroup R1b, of European origin, was predominant in the Andean region, while haplogroup E1b, associated with African ancestry, was more frequent in the Pacific and San Andrés regions. In relatively conserved populations, such as those from the Amazon and La Guajira, a high frequency of haplogroup Q, characteristic of Native American lineages, was detected. Multidimensional scaling (MDS) analyses showed clear genetic separations among regions, reflecting historical and geographical influences. Populations from the Pacific and Caribbean coasts clustered closely with African lineages, while those from the interior of the country exhibited a stronger European influence. In contrast, Indigenous communities and other more conserved populations, such as those in the Amazon, were clearly differentiated, underscoring the preservation of native lineages.The results highlight the genetic complexity of Colombian populations, which have been shaped by the admixture of Native American, African, European, and, to a lesser extent, Middle Eastern lineages. These findings highlight the impact of historical processes, including European colonization, the transatlantic slave trade, and more recent migration events, on the country's genetic structure.© 2025 Wiley Periodicals LLC.Casas-VargasAndreaAGrupo de Genética de Poblaciones e Identificación, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia.GuzmánAlejandra CoronelACGrupo de Genética de Poblaciones e Identificación, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia.AvilaAngie JAJGrupo de Genética de Poblaciones e Identificación, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia.Albarracin-BarreraJulyJGrupo de Genética de Poblaciones e Identificación, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia.Aponte-RubioYuryYGrupo de Genética de Poblaciones e Identificación, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia.SuárezDayanaDGrupo de Genética de Poblaciones e Identificación, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia.Moncada MaderoJulieJGrupo de Genética de Poblaciones e Identificación, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia.MogollónFernandaFGrupo de Genética de Poblaciones e Identificación, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia.BravoNora ContrerasNCSchool of Medicine and Health Sciences, Center for Research in Genetics and Genomics (CIGGUR), Institute of Translational Medicine (IMT), Universidad del Rosario, Bogotá DC, Colombia.MorelAdrienASchool of Medicine and Health Sciences, Center for Research in Genetics and Genomics (CIGGUR), Institute of Translational Medicine (IMT), Universidad del Rosario, Bogotá DC, Colombia.CabreraRodrigoRSchool of Medicine and Health Sciences, Center for Research in Genetics and Genomics (CIGGUR), Institute of Translational Medicine (IMT), Universidad del Rosario, Bogotá DC, Colombia.Fonseca-MendozaDora JanethDJSchool of Medicine and Health Sciences, Center for Research in Genetics and Genomics (CIGGUR), Institute of Translational Medicine (IMT), Universidad del Rosario, Bogotá DC, Colombia.BernalIngrid TatyanaITUniversidad Nacional de Colombia, Bogotá, Colombia.RestrepoCarlos MCMSchool of Medicine and Health Sciences, Center for Research in Genetics and Genomics (CIGGUR), Institute of Translational Medicine (IMT), Universidad del Rosario, Bogotá DC, Colombia.Sánchez-GómezYasmínYUniversidad de Boyacá, Medisens S.A.S, Tunja, Boyacá, Colombia.Usaquén-MartínezWilliamW0000-0001-5409-7125Grupo de Genética de Poblaciones e Identificación, Instituto de Genética, Universidad Nacional de Colombia, Bogotá, Colombia.engMinisterio de Ciencia, Tecnología e InnovaciónDirección de Investigación, Universidad Nacional de ColombiaMinciencias632-2021Minciencias, Project in Health promoting personalized Medicine and Translational ResearchQAN BG273Universidad del RosarioJournal ArticleUnited StatesAm J Hum Biol89150291042-0533IMHumansColombiaChromosomes, Human, YgeneticsMaleGenetic VariationHaplotypesMicrosatellite RepeatsColombiaSouth AmericaY‐STRsY‐chromosomegenetic diversitypopulation genetics2025916202521820251112202512273820251227372025122343ppublish4132802010.1002/ajhb.70171References

Jianxue Xiong, Yu Xu, Guoke Chen et al.

Cell Genomics

China

Chen Jing, J Huang, Yuguo Y et al.

BMC genomics

Jianxue Xiong, Yu Xu, Guoke Chen et al.

Cell genomics

China

Huang Zishuai, Z Gao, Jiaqi J et al.

Genomics

Huber Nicole, N Hurmer, Noah N et al.

NAR genomics and bioinformatics

Zabel Susanne, S Breitling, Samira S et al.

BMC genomics