Active: Primary biliary cirrhosis Clear all

GWAS 2015-09-22

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.

Cordell HJ, Han Y et al.

Nat Commun

Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomo...

Primary biliary cholangitis

Replicated

21216

Participants

N/A

Studies

Details PubMed

GWAS 2012-10-01

Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.

Liu JZ, Almarri MA et al.

Nat Genet

We genotyped 2,861 cases of primary biliary cirrhosis (PBC) from the UK PBC Consortium and 8,514 UK ...

Primary biliary cirrhosis

11375

Participants

N/A

Studies

Details PubMed

GWAS 2012-09-18

Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population.

Nakamura M, Nishida N et al.

Am J Hum Genet

For the identification of susceptibility loci for primary biliary cirrhosis (PBC), a genome-wide ass...

Primary biliary cholangitis

Replicated

2365

Participants

N/A

Studies

Details PubMed

GWAS 2012-08-29

Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants.

Juran BD, Hirschfield GM et al.

Hum Mol Genet

To further characterize the genetic basis of primary biliary cirrhosis (PBC), we genotyped 2426 PBC ...

Primary biliary cirrhosis

7810

Participants

N/A

Studies

Details PubMed

GWAS 2011-03-13

Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.

Mells GF, Floyd JA et al.

Nat Genet

In addition to the HLA locus, six genetic risk factors for primary biliary cirrhosis (PBC) have been...

Primary biliary cholangitis

Replicated

10137

Participants

N/A

Studies

Details PubMed

GWAS 2010-07-18

Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.

Liu X, Invernizzi P et al.

Nat Genet

A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Ital...

Primary biliary cholangitis

Replicated

5585

Participants

N/A

Studies

Details PubMed

GWAS 2009-05-20

Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.

Hirschfield GM, Liu X et al.

N Engl J Med

Primary biliary cirrhosis is a chronic granulomatous cholangitis, characteristically associated with...

Primary biliary cholangitis

Replicated

3744

Participants

N/A

Studies

Details PubMed

Title

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Journal

Disease/Trait

Date

Actions

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.

Cordell HJ, Han Y et al.

Nat Commun

Primary biliary cholangitis

2015-09-22

Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.

Liu JZ, Almarri MA et al.

Nat Genet

Primary biliary cirrhosis

2012-10-01

Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population.

Nakamura M, Nishida N et al.

Am J Hum Genet

Primary biliary cholangitis

2012-09-18

Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants.

Juran BD, Hirschfield GM et al.

Hum Mol Genet

Primary biliary cirrhosis

2012-08-29

Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.

Mells GF, Floyd JA et al.

Nat Genet

Primary biliary cholangitis

2011-03-13

Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.

Liu X, Invernizzi P et al.

Nat Genet

Primary biliary cholangitis

2010-07-18

Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.

Hirschfield GM, Liu X et al.

N Engl J Med

Primary biliary cholangitis

2009-05-20