Ancestry Publications

Singh Vanya, V Basu Mallick, Chandana C et al.

American journal of human biology : the official journal of the Human Biology CouncilAm J Hum BiolAdmixture and Genetic Connectivity: Autosomal Insights Into Indo-Aryan Speakers at the Eastern Edge of the Indian Subcontinent.e70245e7024510.1002/ajhb.70245Assam serves as a melting pot where various ethnicities converge, shaped by its strategic location bordering the six northeastern states and neighboring countries. This study examines the genomic ancestry of Indo-Aryan speakers in Assam, a region at the eastern edge of the Indian subcontinent known for its diverse linguistic and cultural influences. Principal Components Analysis (PCA) revealed that Assamese Indo-Aryans cluster closely with Bangladeshi Indo-Aryans, diverging from the typical South Asian genetic continuum. This group shows significant ancestral influences from East and Southeast Asia. Outgroup f3 statistics indicated that Assamese Indo-Aryans exhibit greater genetic drift in relation to other Indo-Aryan populations, particularly the Harijan and Kol groups from the Ganga plain, rather than with geographically closer Bengali or Nyishi populations. Haplotype-based fine-structure and identity by descent (IBD) analyses confirmed a close genetic affinity with Bangladeshi Indo-Aryans, along with notable connections to Harijan and Kol populations. The low levels of Runs of Homozygosity (RoH) suggest a high degree of genetic diversity, most likely due to a result of admixture and a large effective population size. Admixture events are estimated to have occurred 55 to 61 generations ago, indicating a composition of 76% Indian ancestry and 24% East/Southeast Asian ancestry. These findings, with enhanced resolution, suggest a reconsideration of the previous assumption that Northeast India served as a genetic barrier. Instead, they appear to support its role as a corridor facilitating bidirectional gene flow between South and East/Southeast Asia. Furthermore, the coexistence of diverse linguistic affiliations of ethnic groups in this region reflects in their ancestry patterns. These findings highlight the complex interplay of geography, language, and genetic exchange in the region.© 2026 Wiley Periodicals LLC.SinghVanyaV0000-0002-2832-7393Gyan Lab, Cytogenetics Unit, Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India.Basu MallickChandanaC0000-0001-9459-2710Centre for Genetic Disorders, Banaras Hindu University, Varanasi, Uttar Pradesh, India.ChatterjeeMadhumatiM0000-0002-0136-6149Department of Anthropology, Dr APJ Abdul Kalam Government College, Kolkata, India.TamangRakeshR0000-0001-9873-3066Department of Zoology, University of Calcutta, Kolkata, West Bengal, India.DesaiShaileshS0000-0002-1812-5106Gyan Lab, Cytogenetics Unit, Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India.SinghPrajjval PratapPP0000-0002-8081-5634Laboratory of Genomics and Profiling Applications, BRIC-Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India.MishraRahul KumarRK0000-0003-2608-7856Gyan Lab, Cytogenetics Unit, Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India.Amity Institute of Biotechnology, Amity University Chhattisgarh, Raipur, India.PandeyRudra KumarRK0000-0002-0995-923XGyan Lab, Cytogenetics Unit, Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India.MishraRitushaR0000-0003-4533-0727Department of Radiotherapy and Radiation Medicines, Banaras Hindu University, Varanasi, Uttar Pradesh, India.SinghAshishA0000-0002-6819-2905Dr. Lalji Singh Research Centre, Kalwari, Jaunpur, Uttar Pradesh, India.SuravajhalaPrashanthP0000-0002-8535-278XDepartment of Biosciences, Manipal University Jaipur, Jaipur, Rajasthan, India.BandyopadhyayArup RatanAR0000-0003-3119-0022Department of Anthropology, University of Calcutta, Kolkata, West Bengal, India.ChaubeyGyaneshwerG0000-0003-2899-3852Gyan Lab, Cytogenetics Unit, Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India.eng6031BHU IoE incentive grant BHU2021-6389Indian Council of Medical Research2021-11289Indian Council of Medical ResearchDepartment of Zoology, BHUJournal ArticleUnited StatesAm J Hum Biol89150291042-0533IMHumansIndiaHaplotypesGene FlowPrincipal Component AnalysisGenetic VariationEthnicitygeneticsGenetics, PopulationAsian PeoplegeneticsIndo‐AryanNortheast IndiaTibeto‐Burmanadmixtureautosomesgeneflow20263520251062026310202632071120263207102026320213ppublish4185809810.1002/ajhb.70245References

India

Bangyan Wang, Rui Wang, Duo Zheng et al.

Journal of Genetics and Genomics

China

Jianxue Xiong, Yu Xu, Guoke Chen et al.

Cell Genomics

China

Jianxue Xiong, Yu Xu, Guoke Chen et al.

Cell genomics

China

Huang Zishuai, Z Gao, Jiaqi J et al.

Genomics

Artem Nedoluzhko, Ekaterina Vergasova, Fedor Sharko et al.

BMC genomics

Russia

Artem Nedoluzhko, Ekaterina Vergasova, Fedor Sharko et al.

BMC Genomics

Tuva (Turan-Uyuk Basin, "Valley of the Kings"), Southern Siberia, Central Asia

Bánfai Zsolt, Z Büki, Gergely G et al.

BMC genomics

Slimak Ludovic, L Vimala, Tharsika T et al.

Cell genomics

Wang Ke, K Prüfer, Kay K et al.

Cell genomics

Li Jiawei, J Cai, Dawei D et al.

American journal of physical anthropologyAm J Phys AnthropolAncient DNA reveals two paternal lineages C2a1a1b1a/F3830 and C2b1b/F845 in past nomadic peoples distributed on the Mongolian Plateau.402411402-41110.1002/ajpa.24076Since the third century CE, a series of nomadic tribes have been active on the eastern part of the Mongolian Plateau. Characterizing the genetic compositions of past nomadic people is significant for research on the nomadic cultures of the Eurasian Steppe region. Ancient DNA analysis facilitates a deeper understanding of the relationship between historical and modern nomadic populations.Whole-genome shotgun sequencing and capture sequencing of the nonrecombining region of the Y chromosome were performed for six ancient Hg C2/M217 individuals. The individuals were interred at six separate sites on the Mongolian Plateau and represent dates spanning the late Neolithic to Yuan Dynasty (~3,500-700 BP).After NRY capture sequencing, three of the six ancient samples were attributed to C2b1b/F845 and the other three ancient samples belonged to C2a1a1b1a/F3830. Analysis of whole-genome shotgun sequencing data shows that the ancient C2b1b/F845 individuals are closely related to She, Han and other East Asian populations, while the ancient C2a1a1b1a/F3830 individuals are more similar to modern Northeast Asian peoples, such as the Ulchi and Yakut.Hg C2/M217, widely distributed in the eastern part of the Eurasian continent, was discovered in the ancient Central Steppe and Baikal region. This study shows that there were two important subclades of Hg C2/M217 among the ancient nomadic peoples: C2a1a1b1a/F3830, which has made important genetic contributions to modern Mongolic- and Manchu-speaking populations, and C2b1b/F845, which probably originated in the farming populations of southern East Asia and made certain genetic contributions to past nomadic peoples on the Mongolian Plateau.© 2020 Wiley Periodicals, Inc.LiJiaweiJAncient DNA Laboratory, Research Center for Chinese Frontier Archaeology, Jilin University, Changchun, People's Republic of China.CaiDaweiDAncient DNA Laboratory, Research Center for Chinese Frontier Archaeology, Jilin University, Changchun, People's Republic of China.ZhangYeYCollege of Life Science, Jilin University, Changchun, People's Republic of China.ZhuHongHAncient DNA Laboratory, Research Center for Chinese Frontier Archaeology, Jilin University, Changchun, People's Republic of China.ZhouHuiH0000-0001-5858-5636Ancient DNA Laboratory, Research Center for Chinese Frontier Archaeology, Jilin University, Changchun, People's Republic of China.College of Life Science, Jilin University, Changchun, People's Republic of China.engHistorical ArticleJournal ArticleResearch Support, Non-U.S. Gov't20200514United StatesAm J Phys Anthropol04006540002-94830DNA, AncientIMAnthropology, PhysicalChromosomes, Human, YgeneticsDNA, AncientanalysisEthnicitygeneticshistoryGenome, HumangeneticsGenomicsmethodsHistory, AncientHumansMaleMongoliaSequence Analysis, DNAmethodsTransients and MigrantshistoryNRY captureancient DNAnomadic populationshotgun sequencing2019742020492020417202051560202112660202051560ppublish3240695410.1002/ajpa.24076REFERENCES

Jatupol Kampuansai, Wibhu Kutanan, Eszter Dudás et al.

Molecular genetics and genomics : MGG

North Sea