Genetic Predisposition
Based on your genetic markers, your predisposition to this trait is shown below
Your Result
Higher Narcolepsy susceptibility predisposition
Was this result accurate for you?
Scientific Evidence
Understanding the Data
- SNP: A specific genetic marker relevant to this trait (e.g., rs2588978)
- Genotype: Your genetic makeup at the given SNP location (e.g., CC)
- Variant allele: The alternative DNA sequence at the SNP site
- Variant allele frequency: Percentage of population carrying this variant
- Variant found: Whether the variant was detected in your DNA file
CTSH GeneCards
The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs2289702 | -- | C | T | 7.69% | No Data |
GJB5 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
IL10RB GeneCards
The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs2834168 | -- | A | G | 22.94% | No Data |
MIR552 GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs10915020 | -- | T | A | 8.40% | No Data |
PKN2 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
ZNF365 GeneCards
This gene encodes a zinc finger protein that may play a role in the repair of DNA damage and maintenance of genome stability. The N-terminal C2H2 zinc finger motif is required to form a protein complex with PARP1 and MRE11, which are known to be involved in the restart of stalled DNA replication forks. A mutation in this gene may be associated with breast cancer susceptibility.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs10995245 | -- | G | A | 34.80% | No Data |
These are the genetic markers (SNPs) analyzed for this trait. Variations detected in your genome are listed under the "Genotype" column. SNPs showing "--" were not identified in your DNA file.
| SNP | Chromosome | Genotype | Variant Allele | Frequency |
|---|---|---|---|---|
| rs7553711 | 1 | TC | C | 28.50% |
| rs306336 | 1 | -- | G | 2.30% |
| rs10915020 | 1 | -- | A | 8.40% |
| rs1027327 | 3 | -- | G | 9.50% |
| rs10995245 | 10 | -- | A | 34.80% |
| rs1154155 | 14 | -- | G | 14.80% |
| rs2289702 | 15 | -- | T | 7.69% |
| rs2834168 | 21 | -- | G | 22.94% |
The following peer-reviewed scientific studies support the genetic associations analyzed in this report.
What's Next?
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