Genetic Predisposition
Based on your genetic markers, your predisposition to this trait is shown below
Your Result
Lower Motion sickness resistance
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Scientific Evidence
Understanding the Data
- SNP: A specific genetic marker relevant to this trait (e.g., rs2588978)
- Genotype: Your genetic makeup at the given SNP location (e.g., CC)
- Variant allele: The alternative DNA sequence at the SNP site
- Variant allele frequency: Percentage of population carrying this variant
- Variant found: Whether the variant was detected in your DNA file
ACO1 GeneCards
aconitase 1
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs10970305 | A C | A | C | 50.50% | Detected |
AGA GeneCards
This gene encodes a member of the N-terminal nucleophile (Ntn) hydrolase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta chains that comprise the mature enzyme. This enzyme is involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. Mutations in this gene are associated with the lysosomal storage disease aspartylglycosaminuria that results in progressive neurodegeneration. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is subject to proteolytic processing.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs1378552 | T T | C | T | 32.20% | Detected |
CELF2 GeneCards
CUGBP Elav-like family member 2
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs10752212 | G A | G | A | 53.20% | Detected |
MAP2K5 GeneCards
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs997295 | T T | G | T | 58.80% | Detected |
POU6F2 GeneCards
This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs60464047 | T A | T | A | 85.00% | Detected |
SDK1 GeneCards
The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains six immunoglobulin-like domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. Alternative splicing results in multiple transcript variants.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs4343996 | A A | G | A | 45.10% | Detected |
| rs34912216 | -- | G | A | 72.70% | No Data |
AUTS2 GeneCards
This gene has been implicated in neurodevelopment and as a candidate gene for numerous neurological disorders, including autism spectrum disorders, intellectual disability, and developmental delay. Mutations in this gene have also been associated with non-neurological disorders, such as acute lymphoblastic leukemia, aging of the skin, early-onset androgenetic alopecia, and certain cancers. Alternative splicing results in multiple transcript variants encoding different isoforms.
Genomic Location
Associated SNPs
CNTN1 GeneCards
The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs7957589 | -- | A | T | 14.60% | No Data |
GPD2 GeneCards
The protein encoded by this gene localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs56051278 | -- | A | G | 26.50% | No Data |
GPR26 GeneCards
This gene encodes a G protein-couple receptor protein. G-protein-coupled receptors are a large family of membrane proteins that are involved in cellular responses to environmental stimuli, neurotransmitters, and hormones. The encoded protein may play a role in neurodegenerative diseases. Epigenetic silencing of this gene has been observed in gliomas.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs705145 | -- | C | A | 63.80% | No Data |
LRP1B GeneCards
This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of cancer.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs17515225 | -- | T | C | 44.50% | No Data |
| rs34311235 | -- | C | T | 36.80% | No Data |
MCTP2 GeneCards
multiple C2 and transmembrane domain containing 2
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs62018380 | -- | C | A | 86.90% | No Data |
NLGN1 GeneCards
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs11713169 | -- | A | C | 16.00% | No Data |
NR2F2 GeneCards
This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs7170668 | -- | T | C | 63.20% | No Data |
PRDM16 GeneCards
The reciprocal translocation t(1
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs61759167 | -- | C | T | 23.10% | No Data |
RGS5 GeneCards
This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs4076764 | -- | T | C | 64.90% | No Data |
TLE4 GeneCards
TLE family member 4, transcriptional corepressor
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs149951341 | -- | C | A | 79.80% | No Data |
TSHZ1 GeneCards
This gene encodes a colon cancer antigen that was defined by serological analysis of recombinant cDNA expression libraries. The encoded protein is a member of the teashirt C2H2-type zinc-finger protein family and may be involved in transcriptional regulation of developmental processes. Mutations in this gene may be associated with congenital aural atresia syndrome. COMPLETENESS: full length.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs10514168 | -- | C | A | 85.40% | No Data |
UBE2E2 GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs11129078 | -- | G | A | 75.10% | No Data |
These are the genetic markers (SNPs) analyzed for this trait. Variations detected in your genome are listed under the "Genotype" column. SNPs showing "--" were not identified in your DNA file.
| SNP | Chromosome | Genotype | Variant Allele | Frequency |
|---|---|---|---|---|
| rs2318131 | 2 | AC | C | 34.30% |
| rs1847202 | 3 | TC | C | 64.40% |
| rs9834560 | 3 | CA | A | 61.00% |
| rs66800491 | 3 | GA | A | 68.30% |
| rs1378552 | 4 | TT | T | 32.20% |
| rs2153535 | 6 | GG | G | 48.00% |
| rs60464047 | 7 | TA | A | 85.00% |
| rs4343996 | 7 | AA | A | 45.10% |
| rs10970305 | 9 | AC | C | 50.50% |
| rs1782032 | 9 | GG | G | 54.40% |
| rs2150864 | 9 | AA | A | 34.80% |
| rs10752212 | 10 | GA | A | 53.20% |
| rs997295 | 15 | TT | T | 58.80% |
| rs6069325 | 20 | TG | G | 84.10% |
| rs61759167 | 1 | -- | T | 23.10% |
| rs1858111 | 1 | -- | A | 56.70% |
| rs4076764 | 1 | -- | C | 64.90% |
| rs2551802 | 2 | -- | G | 69.70% |
| rs17515225 | 2 | -- | C | 44.50% |
| rs34311235 | 2 | -- | T | 36.80% |
| rs56051278 | 2 | -- | G | 26.50% |
| rs11713169 | 3 | -- | C | 16.00% |
| rs11129078 | 3 | -- | A | 75.10% |
| rs6833641 | 4 | -- | A | 85.20% |
| rs34912216 | 7 | -- | A | 72.70% |
| rs6946969 | 7 | -- | A | 65.80% |
| rs1195218 | 7 | -- | A | 91.60% |
| rs2360806 | 8 | -- | C | 16.20% |
| rs149951341 | 9 | -- | A | 79.80% |
| rs705145 | 10 | -- | A | 63.80% |
| rs7957589 | 12 | -- | T | 14.60% |
| rs62018380 | 15 | -- | A | 86.90% |
| rs7170668 | 15 | -- | C | 63.20% |
| rs9906289 | 17 | -- | T | 4.60% |
| rs10514168 | 18 | -- | A | 85.40% |
The following peer-reviewed scientific studies support the genetic associations analyzed in this report.
What's Next?
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