Genetic Predisposition
Based on your genetic markers, your predisposition to this trait is shown below
Your Result
Lower Regular attendance at a gym or sports club predisposition
Was this result accurate for you?
Scientific Evidence
Understanding the Data
- SNP: A specific genetic marker relevant to this trait (e.g., rs2588978)
- Genotype: Your genetic makeup at the given SNP location (e.g., CC)
- Variant allele: The alternative DNA sequence at the SNP site
- Variant allele frequency: Percentage of population carrying this variant
- Variant found: Whether the variant was detected in your DNA file
BSN GeneCards
Neurotransmitters are released from a specific site in the axon terminal called the active zone, which is composed of synaptic vesicles and a meshwork of cytoskeleton underlying the plasma membrane. The protein encoded by this gene is thought to be a scaffolding protein involved in organizing the presynaptic cytoskeleton. The gene is expressed primarily in neurons in the brain. A similar gene product in rodents is concentrated in the active zone of axon terminals and tightly associated with cytoskeletal structures, and is essential for regulating neurotransmitter release from a subset of synapses.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs11712056 | T C | T | C | 55.64% | Detected |
AMIGO3 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
ANGPTL3 GeneCards
angiopoietin like 3
Genomic Location
No SNPs found for this gene in your DNA data.
APEH GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
CAMKV GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
CDHR4 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
DOCK7 GeneCards
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that plays a role in axon formation and neuronal polarization. The encoded protein displays GEF activity toward RAC1 and RAC3 Rho small GTPases but not toward CDC42. Several transcript variants encoding different isoforms have been found for this gene.
Genomic Location
No SNPs found for this gene in your DNA data.
GMPPB GeneCards
This gene is thought to encode a GDP-mannose pyrophosphorylase. The encoded protein catalyzes the conversion of mannose-1-phosphate and GTP to GDP-mannose, a reaction involved in the production of N-linked oligosaccharides. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Genomic Location
No SNPs found for this gene in your DNA data.
GRM4 GeneCards
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene.
Genomic Location
No SNPs found for this gene in your DNA data.
HMGA1 GeneCards
This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes.
Genomic Location
No SNPs found for this gene in your DNA data.
IP6K1 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
IP6K3 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
ITPR3 GeneCards
This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs2499760 | -- | C | A | 52.68% | No Data |
KANK4 GeneCards
KN motif and ankyrin repeat domains 4
Genomic Location
No SNPs found for this gene in your DNA data.
L1TD1 GeneCards
LINE1 type transposase domain containing 1
Genomic Location
No SNPs found for this gene in your DNA data.
LEMD2 GeneCards
This gene encodes a LEM domain-containing transmembrane protein of the inner nuclear membrane. The protein is involved in nuclear structure organization and plays a role in cell signaling and differentiation. Mutations in this gene result in Cataract 46, juvenile-onset. Multiple transcript variants have been found for this gene.
Genomic Location
No SNPs found for this gene in your DNA data.
MIR1275 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
MIR5193 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
MIR5688 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
MLN GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
MON1A GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
MST1 GeneCards
The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds.
Genomic Location
No SNPs found for this gene in your DNA data.
MST1R GeneCards
This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing.
Genomic Location
No SNPs found for this gene in your DNA data.
RBM5 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
RBM6 GeneCards
RNA binding motif protein 6
Genomic Location
No SNPs found for this gene in your DNA data.
RNF123 GeneCards
The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1. Alternative splicing results in multiple transcript variants.
Genomic Location
No SNPs found for this gene in your DNA data.
SEMA3F GeneCards
semaphorin 3F
Genomic Location
No SNPs found for this gene in your DNA data.
TCF4 GeneCards
This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs1031831 | -- | C | A | 66.82% | No Data |
THSD7B GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs13002862 | -- | C | A | 74.42% | No Data |
TRAIP GeneCards
This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis.
Genomic Location
No SNPs found for this gene in your DNA data.
UBA7 GeneCards
ubiquitin like modifier activating enzyme 7
Genomic Location
No SNPs found for this gene in your DNA data.
USP1 GeneCards
ubiquitin specific peptidase 1
Genomic Location
No SNPs found for this gene in your DNA data.
These are the genetic markers (SNPs) analyzed for this trait. Variations detected in your genome are listed under the "Genotype" column. SNPs showing "--" were not identified in your DNA file.
| SNP | Chromosome | Genotype | Variant Allele | Frequency |
|---|---|---|---|---|
| rs7627971 | 3 | CC | C | 27.27% |
| rs11712056 | 3 | TC | C | 55.64% |
| rs17315037 | 1 | -- | C | 13.68% |
| rs699534 | 1 | -- | C | 42.70% |
| rs13002862 | 2 | -- | A | 74.42% |
| rs2499760 | 6 | -- | A | 52.68% |
| rs5018269 | 9 | -- | T | 65.35% |
| rs1031831 | 18 | -- | A | 66.82% |
The following peer-reviewed scientific studies support the genetic associations analyzed in this report.
What's Next?
Print Report
Download or print this report for your records