Genetic Predisposition
Based on your genetic markers, your predisposition to this trait is shown below
Your Result
Average genetic predisposition
Was this result accurate for you?
Scientific Evidence
Understanding the Data
- SNP: A specific genetic marker relevant to this trait (e.g., rs2588978)
- Genotype: Your genetic makeup at the given SNP location (e.g., CC)
- Variant allele: The alternative DNA sequence at the SNP site
- Variant allele frequency: Percentage of population carrying this variant
- Variant found: Whether the variant was detected in your DNA file
ATF6B GeneCards
The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs185819 | C C | T | C | 53.57% | Detected |
CADM2 GeneCards
cell adhesion molecule 2
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs9875381 | A G | A | G | 40.00% | Detected |
| rs17516256 | -- | G | A | 62.69% | No Data |
| rs9853563 | -- | T | C | 95.14% | No Data |
ARC GeneCards
activity regulated cytoskeleton associated protein
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs13265333 | -- | G | C | 39.80% | No Data |
ARID5B GeneCards
This gene encodes a member of the AT-rich interaction domain (ARID) family of DNA binding proteins. The encoded protein forms a histone H3K9Me2 demethylase complex with PHD finger protein 2 and regulates the transcription of target genes involved in adipogenesis and liver development. This gene also plays a role in cell growth and differentiation of B-lymphocyte progenitors, and single nucleotide polymorphisms in this gene are associated with acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs2588978 | -- | T | C | 48.04% | No Data |
ARPC3 GeneCards
actin related protein 2/3 complex subunit 3
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs61106808 | -- | C | G | 87.61% | No Data |
ATP2B1 GeneCards
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified. COMPLETENESS: complete on the 3' end.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs10858922 | -- | A | G | 27.84% | No Data |
BHLHE22 GeneCards
This gene encodes a protein that belongs to the basic helix-loop-helix (bHLH) family of transcription factors that regulate cell fate determination, proliferation, and differentiation. A similar protein in mouse is required for the development of the dorsal cochlear nuclei, and is thought to play a role in in the differentiation of neurons involved in sensory input. The mouse protein also functions in retinogenesis.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs12546399 | -- | C | T | 11.07% | No Data |
CDSN GeneCards
corneodesmosin
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs541421140 | -- | G | C | 46.17% | No Data |
FOXP1 GeneCards
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. COMPLETENESS: complete on the 3' end.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs11128203 | -- | T | A | 53.44% | No Data |
| rs58294838 | -- | C | G | 82.26% | No Data |
GADD45G GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs10465231 | -- | C | T | 54.89% | No Data |
GIP GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs12325727 | -- | A | G | 46.24% | No Data |
GNL3 GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs13083798 | -- | A | G | 51.37% | No Data |
ID4 GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs72828532 | -- | T | C | 81.95% | No Data |
ISL1 GeneCards
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs6896357 | -- | T | C | 64.84% | No Data |
KANSL1 GeneCards
This gene encodes a nuclear protein that is a subunit of two protein complexes involved with histone acetylation, the MLL1 complex and the NSL1 complex. The corresponding protein in Drosophila interacts with K(lysine) acetyltransferase 8, which is also a subunit of both the MLL1 and NSL1 complexes.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs62062288 | -- | G | A | 21.96% | No Data |
KCNJ4 GeneCards
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs7291841 | -- | G | A | 54.12% | No Data |
NFIC GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs55864511 | -- | A | G | 75.97% | No Data |
NOA1 GeneCards
nitric oxide associated 1
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs35514852 | -- | C | T | 35.74% | No Data |
PAPPA2 GeneCards
This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs10753130 | -- | C | T | 16.52% | No Data |
SGIP1 GeneCards
SH3GL interacting endocytic adaptor 1
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs11208920 | -- | C | A | 43.28% | No Data |
SOX11 GeneCards
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs3922853 | -- | C | A | 17.36% | No Data |
| rs16864081 | -- | C | T | 23.78% | No Data |
TCF4 GeneCards
This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described.
Genomic Location
Associated SNPs
TNXB GeneCards
This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs575377383 | -- | T | C | 92.92% | No Data |
TTBK1 GeneCards
tau tubulin kinase 1
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs75591122 | -- | C | T | 9.06% | No Data |
These are the genetic markers (SNPs) analyzed for this trait. Variations detected in your genome are listed under the "Genotype" column. SNPs showing "--" were not identified in your DNA file.
| SNP | Chromosome | Genotype | Variant Allele | Frequency |
|---|---|---|---|---|
| rs9875381 | 3 | AG | G | 40.00% |
| rs9372625 | 6 | GA | A | 38.24% |
| rs3021058 | 6 | AC | C | 53.86% |
| rs185819 | 6 | CC | C | 53.57% |
| rs4313803 | 16 | GA | A | 58.00% |
| rs11208920 | 1 | -- | A | 43.28% |
| rs10753130 | 1 | -- | T | 16.52% |
| rs761277 | 1 | -- | G | 63.77% |
| rs3922853 | 2 | -- | A | 17.36% |
| rs16864081 | 2 | -- | T | 23.78% |
| rs2652460 | 2 | -- | G | 46.78% |
| rs11128203 | 3 | -- | A | 53.44% |
| rs58294838 | 3 | -- | G | 82.26% |
| rs13083798 | 3 | -- | G | 51.37% |
| rs17516256 | 3 | -- | A | 62.69% |
| rs7643341 | 3 | -- | T | 40.45% |
| rs9853563 | 3 | -- | C | 95.14% |
| rs362307 | 4 | -- | T | 7.52% |
| rs35514852 | 4 | -- | T | 35.74% |
| rs6896357 | 5 | -- | C | 64.84% |
| rs9391786 | 6 | -- | G | 58.02% |
| rs541421140 | 6 | -- | C | 46.17% |
| rs575377383 | 6 | -- | C | 92.92% |
| rs72828532 | 6 | -- | C | 81.95% |
| rs75591122 | 6 | -- | T | 9.06% |
| rs12546399 | 8 | -- | T | 11.07% |
| rs13265333 | 8 | -- | C | 39.80% |
| rs2409691 | 8 | -- | T | 48.22% |
| rs10465231 | 9 | -- | T | 54.89% |
| rs2588978 | 10 | -- | C | 48.04% |
| rs294381 | 11 | -- | C | 28.06% |
| rs2433634 | 12 | -- | C | 71.79% |
| rs61106808 | 12 | -- | G | 87.61% |
| rs10858922 | 12 | -- | G | 27.84% |
| rs7201179 | 16 | -- | C | 43.21% |
| rs12325727 | 17 | -- | G | 46.24% |
| rs62062288 | 17 | -- | A | 21.96% |
| rs299741 | 18 | -- | T | 40.76% |
| rs4801147 | 18 | -- | C | 55.79% |
| rs619466 | 18 | -- | G | 9.38% |
| rs55864511 | 19 | -- | G | 75.97% |
| rs7291841 | 22 | -- | A | 54.12% |
The following peer-reviewed scientific studies support the genetic associations analyzed in this report.
What's Next?
Print Report
Download or print this report for your records