Body Composition

Response to diet

This research area looks at how people vary in their physiological response to changes in diet (for example weight loss, lipid changes, or glucose control on the same eating plan).

GWAS work has examined variants linked to lipid metabolism, insulin sensitivity, and appetite regulation that may modify how the body responds to dietary changes.

This result reflects research-level variation in dietary response and is not a personalized diet plan.

Adherence, baseline body composition, activity, sleep, gut microbiome, medications, and overall health drive most of the real-world response to any diet.

9 SNPs

3 Studies

Oct 14, 2026

DEMO REPORT

Your Analysis

Genetic Tendency

Based on your genetic markers, your tendency toward this trait is shown below

Your Result

Less weight gain on high fat diets

Very Low Very High

Was this result accurate for you?

Confidence Score

Very high

This score indicates how strongly your genetics predispose you to this trait based on 9/9 SNPs detected.

Trait Influence Breakdown

Genetic

60%

Environment

40%

Scientific Evidence

Understanding the Data

SNP: A specific genetic marker relevant to this trait (e.g., rs2588978)
Genotype: Your genetic makeup at the given SNP location (e.g., CC)
Variant allele: The alternative DNA sequence at the SNP site

Variant allele frequency: Percentage of population carrying this variant
Variant found: Whether the variant was detected in your DNA file

Variant Detected

ADIPOQ GeneCards

This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]

Genomic Location

Chr 3 Start: 186,842,704 End: 186,858,463 Build: HG19

5' end 3' end

Associated SNPs

1 / 1 detected

SNP	Genotype	Ref. Allele	Variant Allele	Frequency	Status
rs17300539	A G	G	A	7.53%	Detected
Your Genotype AG Reference Allele G Variant Allele A Population Frequency 7.53% Variant Status Variant Detected Database Link NCBI dbSNP

Variant Detected

APOA2 GeneCards

This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008]

Genomic Location

Chr 1 Start: 161,222,292 End: 161,223,631 Build: HG19

5' end 3' end

Associated SNPs

1 / 1 detected

SNP	Genotype	Ref. Allele	Variant Allele	Frequency	Status
rs5082	A G	G	A	76.30%	Detected
Your Genotype AG Reference Allele G Variant Allele A Population Frequency 76.30% Variant Status Variant Detected Database Link NCBI dbSNP

Variant Detected

APOA5 GeneCards

The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Oct 2009]

Genomic Location

Chr 11 Start: 116,789,367 End: 116,792,420 Build: HG19

5' end 3' end

Associated SNPs

1 / 1 detected

SNP	Genotype	Ref. Allele	Variant Allele	Frequency	Status
rs662799	A G	G	A	83.71%	Detected
Your Genotype AG Reference Allele G Variant Allele A Population Frequency 83.71% Variant Status Variant Detected Database Link NCBI dbSNP

These are the genetic markers (SNPs) analyzed for this trait. Variations detected in your genome are listed under the "Genotype" column. SNPs showing "--" were not identified in your DNA file.

SNP	Chromosome	Genotype	Variant Allele	Frequency
rs5082	1	AG	A	76.30%
rs17300539	3	AG	A	7.53%
rs662799	11	AG	A	83.71%

DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence (build 37/HG19). Other companies may use the opposite strand, so genotypes may need conversion for comparison.

Important Medical Disclaimer

This report is intended for educational and informational purposes only. It is not intended to provide medical advice or be used solely by the customer in the diagnosis, cure, mitigation, treatment, or prevention of any disease or health condition. If you have serious medical conditions, including but not limited to weight-related issues, diabetes, or heart disease, you should not make changes to your diet or exercise routine without consulting your healthcare provider. Under no circumstances should you modify your medication or medical care without professional medical guidance.

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