Genetic Predisposition
Based on your genetic markers, your predisposition to this trait is shown below
Your Result
Higher Triglyceride levels
Was this result accurate for you?
Scientific Evidence
Understanding the Data
- SNP: A specific genetic marker relevant to this trait (e.g., rs2588978)
- Genotype: Your genetic makeup at the given SNP location (e.g., CC)
- Variant allele: The alternative DNA sequence at the SNP site
- Variant allele frequency: Percentage of population carrying this variant
- Variant found: Whether the variant was detected in your DNA file
GCKR GeneCards
This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY).
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs1260326 | C C | T | C | 40.00% | Detected |
WNT4 GeneCards
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs12128312 | G A | G | A | 4.00% | Detected |
AFF3 GeneCards
This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs72966461 | -- | C | T | 1.00% | No Data |
AQP1 GeneCards
This gene encodes a small integral membrane protein with six bilayer spanning domains that functions as a water channel protein. This protein permits passive transport of water along an osmotic gradient. This gene is a possible candidate for disorders involving imbalance in ocular fluid movement.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs76529322 | -- | C | T | 3.00% | No Data |
BTBD11 GeneCards
BTB domain containing 11
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs142551805 | -- | G | A | 4.00% | No Data |
FAM89A GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs75219957 | -- | C | G | 2.00% | No Data |
GHRHR GeneCards
This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature.
Genomic Location
No SNPs found for this gene in your DNA data.
GJA5 GeneCards
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene may be associated with atrial fibrillation. Alternatively spliced transcript variants encoding the same isoform have been described.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs138087311 | -- | T | C | 2.00% | No Data |
GJA8 GeneCards
This gene encodes a transmembrane connexin protein that is necessary for lens growth and maturation of lens fiber cells. The encoded protein is a component of gap junction channels and functions in a calcium and pH-dependent manner. Mutations in this gene have been associated with zonular pulverulent cataracts, nuclear progressive cataracts, and cataract-microcornea syndrome.
Genomic Location
No SNPs found for this gene in your DNA data.
LSAMP GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs72950184 | -- | A | C | 1.00% | No Data |
MAN2A1 GeneCards
mannosidase alpha class 2A member 1
Genomic Location
No SNPs found for this gene in your DNA data.
MRPL14 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
PCDH7 GeneCards
protocadherin 7
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs568152609 | -- | T | C | 1.00% | No Data |
PJA2 GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs114536492 | -- | C | T | 2.00% | No Data |
| rs146746145 | -- | A | G | 2.00% | No Data |
PTPRD GeneCards
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs147513759 | -- | T | C | 1.00% | No Data |
PWWP2B GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs116102213 | -- | C | G | 5.00% | No Data |
RAD18 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
RBFOX1 GeneCards
The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Genomic Location
No SNPs found for this gene in your DNA data.
SFTA1P GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
TCF3 GeneCards
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs59778223 | -- | G | A | 3.00% | No Data |
TMEM132D GeneCards
transmembrane protein 132D
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs114606502 | -- | T | C | 0.10% | No Data |
TOM1 GeneCards
target of myb1 membrane trafficking protein
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs150310295 | -- | C | T | 2.00% | No Data |
TRIM67 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
WWOX GeneCards
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs78637841 | -- | C | G | 0.96% | No Data |
ZBTB40 GeneCards
zinc finger and BTB domain containing 40
Genomic Location
No SNPs found for this gene in your DNA data.
ZNF571 GeneCards
zinc finger protein 571
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs11665759 | -- | C | G | 5.00% | No Data |
ZNF862 GeneCards
zinc finger protein 862
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs139243855 | -- | T | C | 1.00% | No Data |
These are the genetic markers (SNPs) analyzed for this trait. Variations detected in your genome are listed under the "Genotype" column. SNPs showing "--" were not identified in your DNA file.
| SNP | Chromosome | Genotype | Variant Allele | Frequency |
|---|---|---|---|---|
| rs12128312 | 1 | GA | A | 4.00% |
| rs1260326 | 2 | CC | C | 40.00% |
| rs4665972 | 2 | CC | C | 40.00% |
| rs2289123 | 11 | GT | T | 31.00% |
| rs138087311 | 1 | -- | C | 2.00% |
| rs75219957 | 1 | -- | G | 2.00% |
| rs72966461 | 2 | -- | T | 1.00% |
| rs9836545 | 3 | -- | C | 2.00% |
| rs72950184 | 3 | -- | C | 1.00% |
| rs62243377 | 3 | -- | C | 1.00% |
| rs184753612 | 4 | -- | A | 2.00% |
| rs568152609 | 4 | -- | C | 1.00% |
| rs114536492 | 5 | -- | T | 2.00% |
| rs138142645 | 5 | -- | G | 2.00% |
| rs143008449 | 5 | -- | A | 2.00% |
| rs114699399 | 5 | -- | A | 1.00% |
| rs146746145 | 5 | -- | G | 2.00% |
| rs56043653 | 6 | -- | A | 1.00% |
| rs139243855 | 7 | -- | C | 1.00% |
| rs76529322 | 7 | -- | T | 3.00% |
| rs73123056 | 7 | -- | A | 4.00% |
| rs147513759 | 9 | -- | C | 1.00% |
| rs7922453 | 10 | -- | A | 1.00% |
| rs116102213 | 10 | -- | G | 5.00% |
| rs114606502 | 12 | -- | C | 0.10% |
| rs142551805 | 12 | -- | A | 4.00% |
| rs4522365 | 15 | -- | T | 17.00% |
| rs78637841 | 16 | -- | G | 0.96% |
| rs549237563 | 16 | -- | G | 1.00% |
| rs551107164 | 16 | -- | G | 1.00% |
| rs59778223 | 19 | -- | A | 3.00% |
| rs11665759 | 19 | -- | G | 5.00% |
| rs150310295 | 22 | -- | T | 2.00% |
The following peer-reviewed scientific studies support the genetic associations analyzed in this report.
What's Next?
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