Genetic Predisposition
Based on your genetic markers, your predisposition to this trait is shown below
Your Result
Higher Tension susceptibility predisposition
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Scientific Evidence
Understanding the Data
- SNP: A specific genetic marker relevant to this trait (e.g., rs2588978)
- Genotype: Your genetic makeup at the given SNP location (e.g., CC)
- Variant allele: The alternative DNA sequence at the SNP site
- Variant allele frequency: Percentage of population carrying this variant
- Variant found: Whether the variant was detected in your DNA file
CDH13 GeneCards
This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs7194615 | T C | T | C | 44.85% | Detected |
FOXP2 GeneCards
This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs1450832 | A A | G | A | 29.01% | Detected |
| rs17291908 | -- | A | G | 47.58% | No Data |
| rs10228350 | -- | A | T | 41.29% | No Data |
ACVR2A GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs79861172 | -- | G | A | 9.18% | No Data |
ANKRD45 GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs10218528 | -- | T | A | 40.06% | No Data |
BAIAP2 GeneCards
The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs56084168 | -- | C | T | 14.80% | No Data |
ENO1 GeneCards
This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs2100888 | -- | T | A | 36.56% | No Data |
NCAM1 GeneCards
This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein plays a role in the development of the nervous system by regulating neurogenesis, neurite outgrowth, and cell migration. This protein is also involved in the expansion of T lymphocytes, B lymphocytes and natural killer (NK) cells which play an important role in immune surveillance. This protein plays a role in signal transduction by interacting with fibroblast growth factor receptors, N-cadherin and other components of the extracellular matrix and by triggering signalling cascades involving FYN-focal adhesion kinase (FAK), mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinase (PI3K). One prominent isoform of this gene, cell surface molecule CD56, plays a role in several myeloproliferative disorders such as acute myeloid leukemia and differential expression of this gene is associated with differential disease progression. For example, increased expression of CD56 is correlated with lower survival in acute myeloid leukemia patients whereas increased severity of COVID-19 is correlated with decreased abundance of CD56-expressing NK cells in peripheral blood. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs4937872 | -- | A | G | 41.70% | No Data |
PHF5A GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs11090045 | -- | G | A | 30.23% | No Data |
TMEM161B GeneCards
transmembrane protein 161B
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs28738966 | -- | G | A | 21.74% | No Data |
VWDE GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs11509880 | -- | G | A | 34.42% | No Data |
These are the genetic markers (SNPs) analyzed for this trait. Variations detected in your genome are listed under the "Genotype" column. SNPs showing "--" were not identified in your DNA file.
| SNP | Chromosome | Genotype | Variant Allele | Frequency |
|---|---|---|---|---|
| rs4129585 | CC | C | 42.67% | |
| rs4671330 | 2 | GA | A | 33.54% |
| rs1450832 | 7 | AA | A | 29.01% |
| rs9527336 | 13 | AA | A | 27.72% |
| rs7194615 | 16 | TC | C | 44.85% |
| rs3171692 | 22 | CT | T | 32.95% |
| rs10218528 | 1 | -- | A | 40.06% |
| rs2100888 | 1 | -- | A | 36.56% |
| rs144851691 | 2 | -- | T | 0.41% |
| rs79861172 | 2 | -- | A | 9.18% |
| rs9811546 | 3 | -- | A | 31.20% |
| rs2071802 | 3 | -- | G | 11.06% |
| rs2097247 | 3 | -- | T | 9.58% |
| rs2217250 | 5 | -- | G | 20.85% |
| rs5019341 | 5 | -- | C | 24.16% |
| rs2067919 | 5 | -- | C | 34.36% |
| rs10068637 | 5 | -- | A | 27.61% |
| rs6891955 | 5 | -- | C | 35.42% |
| rs6883228 | 5 | -- | C | 18.32% |
| rs28738966 | 5 | -- | A | 21.74% |
| rs1147851 | 6 | -- | G | 28.46% |
| rs11509880 | 7 | -- | A | 34.42% |
| rs17291908 | 7 | -- | G | 47.58% |
| rs10228350 | 7 | -- | T | 41.29% |
| rs3740393 | 10 | -- | C | 14.06% |
| rs4937872 | 11 | -- | G | 41.70% |
| rs10767733 | 11 | -- | A | 40.28% |
| rs2937336 | 13 | -- | A | 27.84% |
| rs988257 | 13 | -- | A | 27.03% |
| rs3751855 | 16 | -- | C | 39.39% |
| rs56084168 | 17 | -- | T | 14.80% |
| rs9611486 | 22 | -- | G | 28.99% |
| rs11090045 | 22 | -- | A | 30.23% |
The following peer-reviewed scientific studies support the genetic associations analyzed in this report.
What's Next?
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