Genetic Predisposition
Based on your genetic markers, your predisposition to this trait is shown below
Your Result
Average genetic predisposition
Was this result accurate for you?
Scientific Evidence
Understanding the Data
- SNP: A specific genetic marker relevant to this trait (e.g., rs2588978)
- Genotype: Your genetic makeup at the given SNP location (e.g., CC)
- Variant allele: The alternative DNA sequence at the SNP site
- Variant allele frequency: Percentage of population carrying this variant
- Variant found: Whether the variant was detected in your DNA file
ELAVL2 GeneCards
The protein encoded by this gene is a neural-specific RNA-binding protein that is known to bind to several 3' UTRs, including its own and also that of FOS and ID. The encoded protein may recognize a GAAA motif in the RNA. Three transcript variants encoding two different isoforms have been found for this gene.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs10119773 | A G | A | G | 46.60% | Detected |
ACBD4 GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs77804065 | -- | C | T | 21.72% | No Data |
ARNTL GeneCards
aryl hydrocarbon receptor nuclear translocator like
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs55769038 | -- | G | A | 42.20% | No Data |
ASTN2 GeneCards
This gene encodes a protein that is expressed in the brain and may function in neuronal migration, based on functional studies of the related astrotactin 1 gene in human and mouse. A deletion at this locus has been associated with schizophrenia. Multiple transcript variants encoding different proteins have been found for this locus.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs35623509 | -- | C | G | 27.15% | No Data |
GOSR2 GeneCards
This gene encodes a trafficking membrane protein which transports proteins among the medial- and trans-Golgi compartments. Due to its chromosomal location and trafficking function, this gene may be involved in familial essential hypertension.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs199525 | -- | T | G | 20.72% | No Data |
HACE1 GeneCards
This gene encodes a HECT domain and ankyrin repeat-containing ubiquitin ligase. The encoded protein is involved in specific tagging of target proteins, leading to their subcellular localization or proteasomal degradation. The protein is a potential tumor suppressor and is involved in the pathophysiology of several tumors, including Wilm's tumor.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs12528131 | -- | A | G | 48.26% | No Data |
HFE GeneCards
The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs1736904 | -- | G | A | 21.60% | No Data |
KLHL29 GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs34657012 | -- | C | A | 27.90% | No Data |
PRKCA GeneCards
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs2109648 | -- | G | A | 36.04% | No Data |
TLR4 GeneCards
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. In silico studies have found a particularly strong binding of surface TLR4 with the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus disease-2019 (COVID-19). This receptor has also been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness, and with susceptibility to age-related macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs524440 | -- | T | G | 4.48% | No Data |
TMPRSS5 GeneCards
transmembrane serine protease 5
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs10789942 | -- | A | G | 47.69% | No Data |
TTC12 GeneCards
tetratricopeptide repeat domain 12
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs12420205 | -- | C | T | 32.25% | No Data |
WDCP GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs56343114 | -- | C | G | 14.37% | No Data |
These are the genetic markers (SNPs) analyzed for this trait. Variations detected in your genome are listed under the "Genotype" column. SNPs showing "--" were not identified in your DNA file.
| SNP | Chromosome | Genotype | Variant Allele | Frequency |
|---|---|---|---|---|
| rs10119773 | 9 | AG | G | 46.60% |
| rs681875 | 1 | -- | A | 20.63% |
| rs780024 | 2 | -- | A | 34.14% |
| rs34657012 | 2 | -- | A | 27.90% |
| rs56343114 | 2 | -- | G | 14.37% |
| rs12616250 | 2 | -- | C | 14.89% |
| rs7569424 | 2 | -- | G | 14.48% |
| rs9467707 | 6 | -- | C | 12.85% |
| rs9461218 | 6 | -- | A | 24.79% |
| rs9366697 | 6 | -- | C | 36.64% |
| rs34961555 | 6 | -- | T | 9.73% |
| rs149949 | 6 | -- | C | 14.63% |
| rs6910838 | 6 | -- | C | 38.84% |
| rs6986 | 6 | -- | C | 22.33% |
| rs200988 | 6 | -- | G | 28.24% |
| rs1736904 | 6 | -- | A | 21.60% |
| rs12528131 | 6 | -- | G | 48.26% |
| rs35623509 | 9 | -- | G | 27.15% |
| rs524440 | 9 | -- | G | 4.48% |
| rs12420205 | 11 | -- | T | 32.25% |
| rs10789942 | 11 | -- | G | 47.69% |
| rs55769038 | 11 | -- | A | 42.20% |
| rs4471723 | 17 | -- | T | 21.93% |
| rs2109648 | 17 | -- | A | 36.04% |
| rs77804065 | 17 | -- | T | 21.72% |
| rs199525 | 17 | -- | G | 20.72% |
| rs2696532 | 17 | -- | G | 21.22% |
| rs62062288 | 17 | -- | A | 21.15% |
| rs1557339 | 18 | -- | A | 26.19% |
The following peer-reviewed scientific studies support the genetic associations analyzed in this report.
What's Next?
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