Your Analysis

Genetic Predisposition

Based on your genetic markers, your predisposition to this trait is shown below

Your Result

Higher Nervousness susceptibility predisposition

Was this result accurate for you?

Scientific Evidence

Understanding the Data
  • SNP: A specific genetic marker relevant to this trait (e.g., rs2588978)
  • Genotype: Your genetic makeup at the given SNP location (e.g., CC)
  • Variant allele: The alternative DNA sequence at the SNP site
  • Variant allele frequency: Percentage of population carrying this variant
  • Variant found: Whether the variant was detected in your DNA file
37 genes analyzed 14 with detected variants
Variant Detected

ACVR2A GeneCards

Genomic Location
Chr 2 Start: 148,602,086 End: 148,688,391 Build: HG19
Associated SNPs
1 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status
Variant Detected

ARHGAP1 GeneCards

Rho GTPase activating protein 1

Genomic Location
Chr 11 Start: 46,698,630 End: 46,722,169 Build: HG19
Associated SNPs
1 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status
Variant Detected

CCHCR1 GeneCards

This gene encodes a protein with five coiled-coil alpha-helical rod domains that is thought to act as a regulator of mRNA metabolism through its interaction with mRNA-decapping protein 4. It localizes to P-bodies, the site of mRNA metabolism, with an N-terminus that is required for this subcellular localization, suggesting it is a P-body component. Naturally occurring mutations in this gene are associated with psoriasis.

Genomic Location
Chr 6 Start: 31,110,216 End: 31,125,974 Build: HG19
Associated SNPs
1 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status
Variant Detected

CENPW GeneCards

Genomic Location
Chr 6 Start: 126,661,261 End: 126,804,466 Build: HG19
Associated SNPs
1 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status
Variant Detected

CHMP4B GeneCards

This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.

Genomic Location
Chr 20 Start: 32,399,154 End: 32,442,172 Build: HG19
Associated SNPs
1 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status
Variant Detected

DPYD GeneCards

The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene.

Genomic Location
Chr 1 Start: 97,543,299 End: 98,386,615 Build: HG19
Associated SNPs
1 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status
Variant Detected

DSCAM GeneCards

DS cell adhesion molecule

Genomic Location
Chr 21 Start: 41,382,926 End: 42,219,084 Build: HG19
Associated SNPs
1 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status
Variant Detected

FBXO31 GeneCards

This gene is a member of the F-box family. Members are classified into three classes according to the substrate interaction domain, FBW for WD40 repeats, FBL for leucing-rich repeats, and FBXO for other domains. This protein, classified into the last category because of the lack of a recognizable substrate binding domain, has been proposed to be a component of the SCF ubiquitination complex. It is thought to bind and recruit substrate for ubiquitination and degradation. This protein may have a role in regulating the cell cycle as well as dendrite growth and neuronal migration. Alternative splicing results in multiple transcript variants.

Genomic Location
Chr 16 Start: 87,360,593 End: 87,425,727 Build: HG19
Associated SNPs
1 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status
Variant Detected

IRF2BPL GeneCards

interferon regulatory factor 2 binding protein like

Genomic Location
Chr 14 Start: 77,490,886 End: 77,495,051 Build: HG19
Associated SNPs
1 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status
Variant Detected

NPIPB11 GeneCards

Genomic Location
Chr 16 Start: 29,392,639 End: 29,415,866 Build: HG19
Associated SNPs
1 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status
Variant Detected

PCDH9 GeneCards

This gene encodes a member of the protocadherin family, and cadherin superfamily, of transmembrane proteins containing cadherin domains. These proteins mediate cell adhesion in neural tissues in the presence of calcium. The encoded protein may be involved in signaling at neuronal synaptic junctions. Sharing a characteristic with other protocadherin genes, this gene has a notably large exon that encodes multiple cadherin domains and a transmembrane region. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. COMPLETENESS: complete on the 3' end.

Genomic Location
Chr 13 Start: 66,876,966 End: 67,804,468 Build: HG19
Associated SNPs
1 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status
Variant Detected

ST13 GeneCards

ST13 Hsp70 interacting protein

Genomic Location
Chr 22 Start: 41,220,539 End: 41,252,643 Build: HG19
Associated SNPs
1 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status
Variant Detected

TLR9 GeneCards

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.

Genomic Location
Chr 3 Start: 52,255,096 End: 52,259,661 Build: HG19
Associated SNPs
1 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status
Variant Detected

TSNARE1 GeneCards

t-SNARE domain containing 1

Genomic Location
Chr 8 Start: 143,293,441 End: 143,484,543 Build: HG19
Associated SNPs
1 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status

BRD2 GeneCards

This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene.

Genomic Location
Chr 6 Start: 32,936,371 End: 32,949,282 Build: HG19
Associated SNPs
0 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status

CACNA2D1 GeneCards

The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion.

Genomic Location
Chr 7 Start: 81,575,760 End: 82,073,272 Build: HG19
Associated SNPs
0 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status

CADM2 GeneCards

cell adhesion molecule 2

Genomic Location
Chr 3 Start: 85,008,140 End: 86,123,579 Build: HG19
Associated SNPs
0 / 2 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status

DENND1A GeneCards

DENN domain containing 1A

Genomic Location
Chr 9 Start: 126,141,937 End: 126,692,405 Build: HG19
Associated SNPs
0 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status

DNAH14 GeneCards

Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. Two major classes of dyneins, axonemal and cytoplasmic, have been identified. DNAH14 is an axonemal dynein heavy chain (DHC) (Vaughan COMPLETENESS: complete on the 3' end.

Genomic Location
Chr 1 Start: 225,117,356 End: 225,586,988 Build: HG19
Associated SNPs
0 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status

FBXL4 GeneCards

This gene encodes a member of the F-box protein family, which are characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one subunit of modular E3 ubiquitin ligase complexes, called SCF complexes, which function in phosphorylation-dependent ubiquitination. The F-box domain mediates protein-protein interactions and binds directly to S-phase kinase-associated protein 1. In addition to an F-box domain, the encoded protein contains at least 9 tandem leucine-rich repeats. The ubiquitin ligase complex containing the encoded protein may function in cell-cycle control by regulating levels of lysine-specific demethylase 4A. Alternative splicing results in multiple transcript variants.

Genomic Location
Chr 6 Start: 99,316,411 End: 99,395,822 Build: HG19
Associated SNPs
0 / 2 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status

HLA-C GeneCards

HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. About 6000 HLA-C alleles have been described. The HLA system plays an important role in the occurrence and outcome of infectious diseases, including those caused by the malaria parasite, the human immunodeficiency virus (HIV), and the severe acute respiratory syndrome coronavirus (SARS-CoV). The structural spike and the nucleocapsid proteins of the novel coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19), are reported to contain multiple Class I epitopes with predicted HLA restrictions. Individual HLA genetic variation may help explain different immune responses to a virus across a population.

Genomic Location
Chr 6 Start: 31,236,526 End: 31,239,869 Build: HG19
Associated SNPs
0 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status

IRF4 GeneCards

The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6

Genomic Location
Chr 6 Start: 391,752 End: 411,443 Build: HG19
Associated SNPs
0 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status

LIN7C GeneCards

Genomic Location
Chr 11 Start: 27,515,965 End: 27,528,316 Build: HG19
Associated SNPs
0 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status

LTBP2 GeneCards

The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion.

Genomic Location
Chr 14 Start: 74,964,886 End: 75,078,940 Build: HG19
Associated SNPs
0 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status

MGA GeneCards

MAX dimerization protein MGA

Genomic Location
Chr 15 Start: 41,952,603 End: 42,062,138 Build: HG19
Associated SNPs
0 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status

NCOA6 GeneCards

nuclear receptor coactivator 6

Genomic Location
Chr 20 Start: 33,302,578 End: 33,413,454 Build: HG19
Associated SNPs
0 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status

NEK4 GeneCards

The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies.

Genomic Location
Chr 3 Start: 52,742,460 End: 52,804,956 Build: HG19
Associated SNPs
0 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status

NF1 GeneCards

This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.

Genomic Location
Chr 17 Start: 29,421,945 End: 29,704,695 Build: HG19
Associated SNPs
0 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status

NFIA GeneCards

This gene encodes a member of the NF1 (nuclear factor 1) family of transcription factors. Multiple transcript variants encoding different isoforms have been found for this gene.

Genomic Location
Chr 1 Start: 61,542,899 End: 61,928,460 Build: HG19
Associated SNPs
0 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status

PPP2R3A GeneCards

This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.

Genomic Location
Chr 3 Start: 135,684,570 End: 135,866,736 Build: HG19
Associated SNPs
0 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status

PSORS1C1 GeneCards

This gene is one of several genes thought to confer susceptibility to psoriasis and systemic sclerosis, located on chromosome 6 near the major histocompatibility complex (MHC) class I region.

Genomic Location
Chr 6 Start: 31,082,577 End: 31,107,869 Build: HG19
Associated SNPs
0 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status

PXMP4 GeneCards

Genomic Location
Chr 20 Start: 32,290,564 End: 32,308,116 Build: HG19
Associated SNPs
0 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status

SLC25A17 GeneCards

Genomic Location
Chr 22 Start: 41,165,634 End: 41,215,350 Build: HG19
Associated SNPs
0 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status

SNCA GeneCards

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.

Genomic Location
Chr 4 Start: 90,645,250 End: 90,759,455 Build: HG19
Associated SNPs
0 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status

TAC1 GeneCards

tachykinin precursor 1

Genomic Location
Chr 7 Start: 97,361,398 End: 97,369,784 Build: HG19
Associated SNPs
0 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status

TRIM8 GeneCards

This gene encodes a member of the tripartite motif (TRIM) protein family. Based on similarities to other proteins, the encoded protein is suspected to be an E3 ubiquitin-protein ligase. Regulation of this gene may be altered in some cancers. Mutations resulting in a truncated protein product have been observed in early-onset epileptic encephalopathy (EOEE).

Genomic Location
Chr 10 Start: 104,404,236 End: 104,418,076 Build: HG19
Associated SNPs
0 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status

ZNF391 GeneCards

Genomic Location
Chr 6 Start: 27,342,394 End: 27,371,687 Build: HG19
Associated SNPs
0 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status
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Coverage: 17/67 SNPs detected (25%)
Reference: Human Genome Build 37 (HG19)
Generated: March 02, 2026
DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence. Other testing companies may report using the opposite strand, requiring conversion for accurate comparison.