Genetic Predisposition
Based on your genetic markers, your predisposition to this trait is shown below
Your Result
Lower Irritability susceptibility predisposition
Was this result accurate for you?
Scientific Evidence
Understanding the Data
- SNP: A specific genetic marker relevant to this trait (e.g., rs2588978)
- Genotype: Your genetic makeup at the given SNP location (e.g., CC)
- Variant allele: The alternative DNA sequence at the SNP site
- Variant allele frequency: Percentage of population carrying this variant
- Variant found: Whether the variant was detected in your DNA file
ALCAM GeneCards
This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs3772556 | C T | C | T | 28.79% | Detected |
DPYS GeneCards
Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs2959025 | A G | A | G | 34.89% | Detected |
FBXL17 GeneCards
F-box and leucine rich repeat protein 17
Genomic Location
Associated SNPs
FOXP2 GeneCards
This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs776472 | T T | C | T | 43.89% | Detected |
| rs1916977 | -- | C | T | 29.91% | No Data |
| rs10228350 | -- | A | T | 41.29% | No Data |
PAX6 GeneCards
This gene encodes paired box protein Pax-6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to a conserved paired box domain, a hallmark feature of this gene family, the encoded protein also contains a homeobox domain. Both domains are known to bind DNA and function as regulators of gene transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. This gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing results in multiple transcript variants encoding different isoforms. Interestingly, inclusion of a particular alternate coding exon has been shown to increase the length of the paired box domain and alter its DNA binding specificity. Consequently, isoforms that carry the shorter paired box domain regulate a different set of genes compared to the isoforms carrying the longer paired box domain. COMPLETENESS: complete on the 3' end.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs3026401 | C T | C | T | 21.84% | Detected |
VRK2 GeneCards
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs11682175 | T C | T | C | 46.61% | Detected |
ACSS2 GeneCards
This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs62211616 | -- | G | A | 17.92% | No Data |
ARPP21 GeneCards
This gene encodes a cAMP-regulated phosphoprotein. The encoded protein is enriched in the caudate nucleus and cerebellar cortex. A similar protein in mouse may be involved in regulating the effects of dopamine in the basal ganglia. Alternate splicing results in multiple transcript variants. COMPLETENESS: full length.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs1542212 | -- | T | G | 39.31% | No Data |
AUTS2 GeneCards
This gene has been implicated in neurodevelopment and as a candidate gene for numerous neurological disorders, including autism spectrum disorders, intellectual disability, and developmental delay. Mutations in this gene have also been associated with non-neurological disorders, such as acute lymphoblastic leukemia, aging of the skin, early-onset androgenetic alopecia, and certain cancers. Alternative splicing results in multiple transcript variants encoding different isoforms.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs13223152 | -- | A | G | 40.17% | No Data |
CAMKMT GeneCards
This gene encodes a class I protein methyltransferase that acts in the formation of trimethyllysine in calmodulin. The protein contains a AdoMet-binding motif and may play a role in calcium-dependent signaling.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs343949 | -- | A | T | 17.20% | No Data |
DPYD GeneCards
The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs4411173 | -- | C | A | 16.25% | No Data |
FANCL GeneCards
This gene encodes a ubiquitin ligase that is a member of the Fanconi anemia complementation group (FANC). Members of this group are related by their assembly into a common nuclear protein complex rather than by sequence similarity. This gene encodes the protein for complementation group L that mediates monoubiquitination of FANCD2 as well as FANCI. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. Alternative splicing results in multiple transcript variants.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs2717033 | -- | T | T | 38.92% | No Data |
HCN1 GeneCards
The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs35255819 | -- | A | A | 12.64% | No Data |
LINC01550 GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs12886000 | -- | G | T | 10.55% | No Data |
MSRA GeneCards
methionine sulfoxide reductase A
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs17151565 | -- | C | G | 38.93% | No Data |
MYRF GeneCards
This gene encodes a transcription factor that is required for central nervous system myelination and may regulate oligodendrocyte differentiation. It is thought to act by increasing the expression of genes that effect myelin production but may also directly promote myelin gene expression. Loss of a similar gene in mouse models results in severe demyelination. Alternative splicing results in multiple transcript variants.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs102275 | -- | T | C | 35.60% | No Data |
SIM1 GeneCards
SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or cognitive disability of Down syndrome.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs9403716 | -- | G | A | 22.71% | No Data |
SIX3 GeneCards
This gene encodes a member of the sine oculis homeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in this gene have been associated with holoprosencephaly type 2.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs4953152 | -- | G | A | 31.51% | No Data |
TCF4 GeneCards
This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs7231748 | -- | A | G | 30.70% | No Data |
TLR4 GeneCards
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. In silico studies have found a particularly strong binding of surface TLR4 with the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus disease-2019 (COVID-19). This receptor has also been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness, and with susceptibility to age-related macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs1927903 | -- | G | C | 34.19% | No Data |
These are the genetic markers (SNPs) analyzed for this trait. Variations detected in your genome are listed under the "Genotype" column. SNPs showing "--" were not identified in your DNA file.
| SNP | Chromosome | Genotype | Variant Allele | Frequency |
|---|---|---|---|---|
| rs7535528 | 1 | GA | A | 36.26% |
| rs11682175 | 2 | TC | C | 46.61% |
| rs3772556 | 3 | CT | T | 28.79% |
| rs4634342 | 5 | GT | T | 36.18% |
| rs776472 | 7 | TT | T | 43.89% |
| rs6969188 | 7 | AA | A | 43.86% |
| rs16884419 | 8 | GA | A | 24.35% |
| rs4734804 | 8 | AG | G | 22.03% |
| rs2959025 | 8 | AG | G | 34.89% |
| rs999483 | 9 | TG | G | 24.79% |
| rs3026401 | 11 | CT | T | 21.84% |
| rs11067376 | 12 | AG | G | 35.95% |
| rs631140 | 13 | GG | G | 27.57% |
| rs9527336 | 13 | AA | A | 27.72% |
| rs9938550 | 16 | GG | G | 38.47% |
| rs2217127 | 18 | TG | G | 29.06% |
| rs4411173 | 1 | -- | A | 16.25% |
| rs4953152 | 2 | -- | A | 31.51% |
| rs6711058 | 2 | -- | A | 26.63% |
| rs343949 | 2 | -- | T | 17.20% |
| rs2717033 | 2 | -- | T | 38.92% |
| rs6718682 | 2 | -- | T | 27.49% |
| rs4499638 | 3 | -- | G | 37.04% |
| rs507078 | 3 | -- | T | 29.60% |
| rs3774800 | 3 | -- | A | 35.40% |
| rs6800177 | 3 | -- | T | 25.90% |
| rs6549048 | 3 | -- | A | 29.25% |
| rs1542212 | 3 | -- | G | 39.31% |
| rs35255819 | 5 | -- | A | 12.64% |
| rs1422192 | 5 | -- | A | 16.56% |
| rs10071595 | 5 | -- | A | 48.61% |
| rs6861691 | 5 | -- | C | 43.30% |
| rs6596771 | 5 | -- | A | 48.67% |
| rs9403716 | 6 | -- | A | 22.71% |
| rs1916977 | 7 | -- | T | 29.91% |
| rs13223152 | 7 | -- | G | 40.17% |
| rs10228350 | 7 | -- | T | 41.29% |
| rs17151565 | 8 | -- | G | 38.93% |
| rs3110417 | 8 | -- | G | 25.15% |
| rs1927903 | 9 | -- | C | 34.19% |
| rs10905619 | 10 | -- | G | 25.49% |
| rs10905638 | 10 | -- | C | 44.09% |
| rs1158960 | 10 | -- | C | 24.87% |
| rs102275 | 11 | -- | C | 35.60% |
| rs7973253 | 12 | -- | G | 36.97% |
| rs58446129 | 13 | -- | T | 15.60% |
| rs17592462 | 13 | -- | T | 18.89% |
| rs3124405 | 13 | -- | T | 27.71% |
| rs12886000 | 14 | -- | T | 10.55% |
| rs4781534 | 16 | -- | C | 34.36% |
| rs17650842 | 17 | -- | G | 21.66% |
| rs17661015 | 17 | -- | C | 21.51% |
| rs70600 | 17 | -- | T | 20.72% |
| rs2106785 | 17 | -- | T | 21.38% |
| rs2261201 | 17 | -- | C | 21.46% |
| rs9630740 | 17 | -- | G | 26.17% |
| rs62065453 | 17 | -- | T | 21.72% |
| rs62055701 | 17 | -- | A | 21.45% |
| rs2587410 | 18 | -- | T | 25.31% |
| rs4570961 | 18 | -- | T | 32.42% |
| rs28758902 | 18 | -- | T | 43.25% |
| rs7231748 | 18 | -- | G | 30.70% |
| rs6087607 | 20 | -- | G | 17.67% |
| rs62212173 | 20 | -- | T | 13.81% |
| rs62211616 | 20 | -- | A | 17.92% |
| rs7265992 | 20 | -- | A | 18.09% |
| rs4820434 | 22 | -- | T | 31.44% |
The following peer-reviewed scientific studies support the genetic associations analyzed in this report.
What's Next?
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