Genetic Predisposition
Based on your genetic markers, your predisposition to this trait is shown below
Your Result
Higher Tourette syndrome predisposition
Was this result accurate for you?
Scientific Evidence
Understanding the Data
- SNP: A specific genetic marker relevant to this trait (e.g., rs2588978)
- Genotype: Your genetic makeup at the given SNP location (e.g., CC)
- Variant allele: The alternative DNA sequence at the SNP site
- Variant allele frequency: Percentage of population carrying this variant
- Variant found: Whether the variant was detected in your DNA file
FPR1 GeneCards
This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs12459560 | G T | G | T | 15.35% | Detected |
AAMDC GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs17137210 | -- | T | C | 1.17% | No Data |
ADAMTS7P1 GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs66904072 | -- | A | G | 3.63% | No Data |
AHCTF1P1 GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs13407215 | -- | C | T | 1.70% | No Data |
ALG8 GeneCards
This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation of proteins. Mutations in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ih). Alternatively spliced transcript variants encoding different isoforms have been identified.
Genomic Location
No SNPs found for this gene in your DNA data.
AP3B2 GeneCards
Adaptor protein complex 3 (AP-3 complex) is a heterotrimeric protein complex involved in the formation of clathrin-coated synaptic vesicles. The protein encoded by this gene represents the beta subunit of the neuron-specific AP-3 complex and was first identified as the target antigen in human paraneoplastic neurologic disorders. The encoded subunit binds clathrin and is phosphorylated by a casein kinase-like protein, which mediates synaptic vesicle coat assembly. Defects in this gene are a cause of early-onset epileptic encephalopathy.
Genomic Location
No SNPs found for this gene in your DNA data.
AQP11 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
ARL6IP4 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
BAZ2B GeneCards
This gene belongs to the bromodomain gene family. Members of this gene family encode proteins that are integral components of chromatin remodeling complexes. The encoded protein showed strong preference for the activating H3K14Ac mark in a histone peptide screen, suggesting a potential role in transcriptional activation. This gene may be associated with susceptibility to sudden cardiac death (SCD).
Genomic Location
No SNPs found for this gene in your DNA data.
CCDC62 GeneCards
coiled-coil domain containing 62
Genomic Location
No SNPs found for this gene in your DNA data.
CD276 GeneCards
The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Genomic Location
No SNPs found for this gene in your DNA data.
CD302 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
CDK2AP1 GeneCards
cyclin dependent kinase 2 associated protein 1
Genomic Location
No SNPs found for this gene in your DNA data.
CLNS1A GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
CPEB1 GeneCards
cytoplasmic polyadenylation element binding protein 1
Genomic Location
No SNPs found for this gene in your DNA data.
CSMD3 GeneCards
CUB and Sushi multiple domains 3
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs117648881 | -- | G | A | 97.62% | No Data |
DPP4 GeneCards
dipeptidyl peptidase 4
Genomic Location
No SNPs found for this gene in your DNA data.
EPB41 GeneCards
The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Genomic Location
No SNPs found for this gene in your DNA data.
FLT3 GeneCards
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs2504235 | -- | A | G | 38.48% | No Data |
FPR2 GeneCards
formyl peptide receptor 2
Genomic Location
No SNPs found for this gene in your DNA data.
FPR3 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
FSD2 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
GAB2 GeneCards
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
Genomic Location
No SNPs found for this gene in your DNA data.
GDPD4 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
GOLGA6L10 GeneCards
golgin A6 family like 10
Genomic Location
No SNPs found for this gene in your DNA data.
GOLGA6L17P GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
GOLGA6L9 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
HIP1R GeneCards
huntingtin interacting protein 1 related
Genomic Location
No SNPs found for this gene in your DNA data.
HOMER2 GeneCards
This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein. Alternative splicing results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 14.
Genomic Location
No SNPs found for this gene in your DNA data.
INTS4 GeneCards
integrator complex subunit 4
Genomic Location
No SNPs found for this gene in your DNA data.
ITGB6 GeneCards
This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms a dimer with an alpha v chain and this heterodimer can bind to ligands like fibronectin and transforming growth factor beta 1. Alternate splicing results in multiple transcript variants.
Genomic Location
No SNPs found for this gene in your DNA data.
KCTD14 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
KCTD21 GeneCards
potassium channel tetramerization domain containing 21
Genomic Location
No SNPs found for this gene in your DNA data.
KCTD21-AS1 GeneCards
KCTD21 antisense RNA 1
Genomic Location
No SNPs found for this gene in your DNA data.
LMO3 GeneCards
The protein encoded by this gene belongs to the rhombotin family of cysteine-rich LIM domain oncogenes. This gene is predominantly expressed in the brain. Related family members, LMO1 and LMO2 on chromosome 11, have been reported to be involved in chromosomal translocations in T-cell leukemia. Many alternatively spliced transcript variants have been found for this gene.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs10846381 | -- | A | T | 58.97% | No Data |
LOC101929512 GeneCards
uncharacterized LOC101929512
Genomic Location
No SNPs found for this gene in your DNA data.
LOC102724034 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
LOC727751 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
LY75 GeneCards
lymphocyte antigen 75
Genomic Location
No SNPs found for this gene in your DNA data.
LY75-CD302 GeneCards
LY75-CD302 readthrough
Genomic Location
No SNPs found for this gene in your DNA data.
MECR GeneCards
The protein encoded by this gene is an oxidoreductase that catalyzes the last step in mitochondrial fatty acid synthesis. Defects in this gene are a cause of childhood-onset dystonia and optic atrophy.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs6670211 | -- | A | C | 53.47% | No Data |
MEX3B GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
MIR2053 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
MIR4304 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
MIR4785 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
MIR8072 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
MPHOSPH9 GeneCards
M-phase phosphoprotein 9
Genomic Location
No SNPs found for this gene in your DNA data.
MUC16 GeneCards
This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs150975336 | -- | C | G | 2.69% | No Data |
MYO7A GeneCards
This gene is a member of the myosin gene family. Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. This gene encodes an unconventional myosin with a very short tail. Defects in this gene are associated with the mouse shaker-1 phenotype and the human Usher syndrome 1B which are characterized by deafness, reduced vestibular function, and (in human) retinal degeneration. Alternative splicing results in multiple transcript variants.
Genomic Location
No SNPs found for this gene in your DNA data.
NARS2 GeneCards
This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of asparagine to tRNA molecules. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency 24 (COXPD24).
Genomic Location
No SNPs found for this gene in your DNA data.
NDUFC2 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
NDUFC2-KCTD14 GeneCards
NDUFC2-KCTD14 readthrough
Genomic Location
No SNPs found for this gene in your DNA data.
NPTN GeneCards
neuroplastin
Genomic Location
No SNPs found for this gene in your DNA data.
NPTN-IT1 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
OGFOD2 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
OPRD1 GeneCards
opioid receptor delta 1
Genomic Location
No SNPs found for this gene in your DNA data.
OTUD1 GeneCards
OTU deubiquitinase 1
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs191044310 | -- | T | A | 97.78% | No Data |
PAK1 GeneCards
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Mutations in this gene have been associated with macrocephaly, seizures, and speech delay. Overexpression of this gene is also reported in many cancer types, and particularly in breast cancer. Alternative splicing results in multiple transcript variants.
Genomic Location
No SNPs found for this gene in your DNA data.
PITPNM2 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
PLA2R1 GeneCards
phospholipase A2 receptor 1
Genomic Location
No SNPs found for this gene in your DNA data.
PSMD14 GeneCards
proteasome 26S subunit, non-ATPase 14
Genomic Location
No SNPs found for this gene in your DNA data.
PTPRU GeneCards
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported.
Genomic Location
No SNPs found for this gene in your DNA data.
RBMS1 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
REC114 GeneCards
REC114 meiotic recombination protein
Genomic Location
No SNPs found for this gene in your DNA data.
RILPL2 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
RNF4 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
RNU6-83P GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
RPS17 GeneCards
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S17E family of ribosomal proteins and is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia 4. Alternative splicing of this gene results in multiple transcript variants. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
Genomic Location
No SNPs found for this gene in your DNA data.
RSF1 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
SBNO1 GeneCards
strawberry notch homolog 1
Genomic Location
No SNPs found for this gene in your DNA data.
SCARNA15 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
SLC4A10 GeneCards
This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Genomic Location
No SNPs found for this gene in your DNA data.
SNHG21 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
SRSF4 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
TANC1 GeneCards
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Genomic Location
No SNPs found for this gene in your DNA data.
TANK GeneCards
TRAF family member associated NFKB activator
Genomic Location
No SNPs found for this gene in your DNA data.
TBR1 GeneCards
This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of numerous developmental processes. In mouse, the ortholog of this gene is expressed in the cerebral cortex, hippocampus, amygdala and olfactory bulb and is thought to play an important role in neuronal migration and axonal projection. In mouse, the C-terminal region of this protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase.
Genomic Location
No SNPs found for this gene in your DNA data.
TENM2 GeneCards
teneurin transmembrane protein 2
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs147208935 | -- | C | T | 1.00% | No Data |
TENM4 GeneCards
The protein encoded by this gene plays a role in establishing proper neuronal connectivity during development. Defects in this gene have been associated with hereditary essential tremor-5.
Genomic Location
No SNPs found for this gene in your DNA data.
THRSP GeneCards
thyroid hormone responsive
Genomic Location
No SNPs found for this gene in your DNA data.
TMEM200B GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
TSHR GeneCards
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs66489957 | -- | T | C | 76.92% | No Data |
TSPYL5 GeneCards
TSPY like 5
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs117780640 | -- | C | G | 86.39% | No Data |
UBE2Q2P2 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
USP35 GeneCards
ubiquitin specific peptidase 35
Genomic Location
No SNPs found for this gene in your DNA data.
VPS37B GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
WDSUB1 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
WHAMM GeneCards
WASP homolog associated with actin, golgi membranes and microtubules
Genomic Location
No SNPs found for this gene in your DNA data.
XYLT1 GeneCards
This locus encodes a xylosyltransferase enzyme. The encoded protein catalyzes transfer of UDP-xylose to serine residues of an acceptor protein substrate. This transfer reaction is necessary for biosynthesis of glycosaminoglycan chains. Mutations in this gene have been associated with increased severity of pseudoxanthoma elasticum.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs74772983 | -- | A | T | 92.81% | No Data |
ZFYVE28 GeneCards
zinc finger FYVE-type containing 28
Genomic Location
No SNPs found for this gene in your DNA data.
ZNF350 GeneCards
zinc finger protein 350
Genomic Location
No SNPs found for this gene in your DNA data.
ZNF432 GeneCards
zinc finger protein 432
Genomic Location
No SNPs found for this gene in your DNA data.
ZNF577 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
ZNF613 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
ZNF614 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
ZNF615 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
ZNF616 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
ZNF649 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
ZNF841 GeneCards
Genomic Location
No SNPs found for this gene in your DNA data.
These are the genetic markers (SNPs) analyzed for this trait. Variations detected in your genome are listed under the "Genotype" column. SNPs showing "--" were not identified in your DNA file.
| SNP | Chromosome | Genotype | Variant Allele | Frequency |
|---|---|---|---|---|
| rs2708146 | 2 | AG | G | 54.50% |
| rs4886520 | 15 | TC | C | 55.32% |
| rs12459560 | 19 | GT | T | 15.35% |
| rs6670211 | 1 | -- | C | 53.47% |
| rs1865896 | 2 | -- | G | 50.52% |
| rs13407215 | 2 | -- | T | 1.70% |
| rs6445765 | 3 | -- | A | 62.79% |
| rs73205493 | 4 | -- | T | 34.36% |
| rs4047771 | 4 | -- | C | 67.64% |
| rs147208935 | 5 | -- | T | 1.00% |
| rs1906252 | 6 | -- | A | 50.87% |
| rs72673503 | 8 | -- | A | 14.51% |
| rs117780640 | 8 | -- | G | 86.39% |
| rs117648881 | 8 | -- | A | 97.62% |
| rs72734943 | 9 | -- | A | 1.40% |
| rs191044310 | 10 | -- | A | 97.78% |
| rs17137210 | 11 | -- | C | 1.17% |
| rs1619561 | 12 | -- | C | 76.59% |
| rs10846381 | 12 | -- | T | 58.97% |
| rs2504235 | 13 | -- | G | 38.48% |
| rs66489957 | 14 | -- | C | 76.92% |
| rs66904072 | 15 | -- | G | 3.63% |
| rs74772983 | 16 | -- | T | 92.81% |
| rs150975336 | 19 | -- | G | 2.69% |
The following peer-reviewed scientific studies support the genetic associations analyzed in this report.
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