Genetic Predisposition
Based on your genetic markers, your predisposition to this trait is shown below
Your Result
Lower Frontal fibrosing alopecia susceptibility predisposition
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Scientific Evidence
Understanding the Data
- SNP: A specific genetic marker relevant to this trait (e.g., rs2588978)
- Genotype: Your genetic makeup at the given SNP location (e.g., CC)
- Variant allele: The alternative DNA sequence at the SNP site
- Variant allele frequency: Percentage of population carrying this variant
- Variant found: Whether the variant was detected in your DNA file
CYP1B1 GeneCards
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs1800440 | T C | T | C | 81.00% | Detected |
HLA-A GeneCards
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen so that they can be recognized by cytotoxic T cells. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. More than 6000 HLA-A alleles have been described. The HLA system plays an important role in the occurrence and outcome of infectious diseases, including those caused by the malaria parasite, the human immunodeficiency virus (HIV), and the severe acute respiratory syndrome coronavirus (SARS-CoV). The structural spike and the nucleocapsid proteins of the novel coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19), are reported to contain multiple Class I epitopes with predicted HLA restrictions. Individual HLA genetic variation may help explain different immune responses to a virus across a population.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| HLA-A*33:01 | -- | ? | ? | 0.60% | No Data |
| HLA-A*11:01 | -- | ? | ? | 5.90% | No Data |
HLA-B GeneCards
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| HLA-B*07:02 | -- | ? | ? | 14.10% | No Data |
| rs2523616 | -- | T | C | 19.00% | No Data |
SEMA4B GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs34560261 | -- | C | T | 22.00% | No Data |
These are the genetic markers (SNPs) analyzed for this trait. Variations detected in your genome are listed under the "Genotype" column. SNPs showing "--" were not identified in your DNA file.
| SNP | Chromosome | Genotype | Variant Allele | Frequency |
|---|---|---|---|---|
| rs1800440 | 2 | TC | C | 81.00% |
| rs277580 | 9 | GG | G | 83.70% |
| rs6540122 | 16 | CT | T | 16.00% |
| HLA-B*07:02 | -- | ? | 14.10% | |
| HLA-A*33:01 | -- | ? | 0.60% | |
| HLA-A*11:01 | -- | ? | 5.90% | |
| rs13032164 | 2 | -- | G | 83.60% |
| rs78504246 | 2 | -- | A | 0.50% |
| rs6731286 | 2 | -- | T | 65.80% |
| rs13078360 | 3 | -- | G | 20.00% |
| rs116806118 | 3 | -- | T | 0.50% |
| rs1461070 | 3 | -- | A | 1.70% |
| rs114108912 | 3 | -- | C | 1.00% |
| rs10045403 | 5 | -- | G | 26.60% |
| rs73062921 | 5 | -- | A | 11.30% |
| rs34097647 | 6 | -- | T | 19.70% |
| rs62388754 | 6 | -- | T | 5.80% |
| rs142366299 | 6 | -- | T | 1.20% |
| rs7749944 | 6 | -- | C | 0.60% |
| rs148661203 | 6 | -- | T | 0.70% |
| rs147324178 | 6 | -- | C | 14.40% |
| rs2523616 | 6 | -- | C | 19.00% |
| rs112115472 | 7 | -- | T | 96.30% |
| rs7806494 | 7 | -- | T | 72.30% |
| rs2021162 | 7 | -- | A | 27.60% |
| rs6975452 | 7 | -- | A | 50.40% |
| rs760327 | 8 | -- | C | 39.00% |
| rs2773871 | 9 | -- | A | 80.20% |
| rs112198986 | 10 | -- | T | 3.70% |
| rs117687547 | 10 | -- | T | 3.10% |
| rs111463574 | 12 | -- | T | 91.50% |
| rs10507508 | 13 | -- | G | 4.40% |
| rs34560261 | 15 | -- | T | 22.00% |
| rs8065764 | 17 | -- | C | 87.70% |
| rs12951836 | 17 | -- | G | 50.70% |
| rs112659862 | 17 | -- | C | 0.50% |
| rs79459566 | 19 | -- | T | 4.00% |
The following peer-reviewed scientific studies support the genetic associations analyzed in this report.
What's Next?
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