Physical Traits

Eruption of permanent teeth

The timing of permanent tooth eruption in childhood varies between people and is partly heritable.

GWAS work has identified variants near tooth-development genes (such as KCNJ2 and EDA) linked to differences in eruption timing.

This result reflects research-level variation in dental biology and is not a clinical assessment of dental development.

Nutrition, growth, oral health, primary tooth loss timing, and overall development also affect when permanent teeth come in.

6 SNPs

2 Studies

Oct 14, 2026

DEMO REPORT

Your Analysis

Genetic Tendency

Based on your genetic markers, your tendency toward this trait is shown below

Your Result

Less number of permanent teeth before 14 years old

Very Low Very High

Was this result accurate for you?

Confidence Score

Very high

This score indicates how strongly your genetics predispose you to this trait based on 6/6 SNPs detected.

Trait Influence Breakdown

Genetic

85%

Environment

15%

Scientific Evidence

Understanding the Data

SNP: A specific genetic marker relevant to this trait (e.g., rs2588978)
Genotype: Your genetic makeup at the given SNP location (e.g., CC)
Variant allele: The alternative DNA sequence at the SNP site

Variant allele frequency: Percentage of population carrying this variant
Variant found: Whether the variant was detected in your DNA file

Variant Detected

ADK GeneCards

This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Genomic Location

Chr 10 Start: 74,151,185 End: 74,709,963 Build: HG19

5' end 3' end

Associated SNPs

1 / 1 detected

SNP	Genotype	Ref. Allele	Variant Allele	Frequency	Status
rs7924176	G G	A	G	18.11%	Detected
Your Genotype GG Reference Allele A Variant Allele G Population Frequency 18.11% Variant Status Variant Detected Database Link NCBI dbSNP

Variant Detected

CACNA1S GeneCards

This gene encodes one of the five subunits of the slowly inactivating L-type voltage-dependent calcium channel in skeletal muscle cells. Mutations in this gene have been associated with hypokalemic periodic paralysis, thyrotoxic periodic paralysis and malignant hyperthermia susceptibility. [provided by RefSeq, Jul 2008]

Genomic Location

Chr 1 Start: 201,039,509 End: 201,112,453 Build: HG19

5' end 3' end

Associated SNPs

1 / 1 detected

SNP	Genotype	Ref. Allele	Variant Allele	Frequency	Status
rs2281845	C T	C	T	58.89%	Detected
Your Genotype CT Reference Allele C Variant Allele T Population Frequency 58.89% Variant Status Variant Detected Database Link NCBI dbSNP

These are the genetic markers (SNPs) analyzed for this trait. Variations detected in your genome are listed under the "Genotype" column. SNPs showing "--" were not identified in your DNA file.

SNP	Chromosome	Genotype	Variant Allele	Frequency
rs2281845	1	CT	T	58.89%
rs7924176	10	GG	G	18.11%

DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence (build 37/HG19). Other companies may use the opposite strand, so genotypes may need conversion for comparison.

The following peer-reviewed scientific studies support the genetic associations analyzed in this report.

Genome-wide association study reveals multiple loci associated with primary tooth development during infancy

Evidence

02/26/2010

PLoS Genet

Authors: Pillas D, Hoggart CJ, Evans DM, O&#39, Reilly PF, Sipilä K, Lähdesmäki R, Millwood IY, Kaakinen M, Netuveli G, Blane D, Charoen P, Sovio U, Pouta A, Freimer N, Hartikainen AL, Laitinen J, Vaara S, Glaser B, Crawford P, Timpson NJ, Ring SM, Deng G, Zhang W, McCarthy MI, Deloukas P, Peltonen L, Elliott P, Coin LJ, Smith GD, Jarvelin MR

5,752 individuals (european ancestry)

Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances

Evidence

09/15/2013

Hum Mol Genet

Authors: Fatemifar G, Hoggart CJ, Paternoster L, Kemp JP, Prokopenko I, Horikoshi M, Wright VJ, Tobias JH, Richmond S, Zhurov AI, Toma AM, Pouta A, Taanila A, Sipila K, Lähdesmäki R, Pillas D, Geller F, Feenstra B, Melbye M, Nohr EA, Ring SM, St Pourcain B, Timpson NJ, Davey Smith G, Jarvelin MR, Evans DM

11,513 individuals (european ancestry)

Important Medical Disclaimer

This report is intended for educational and informational purposes only. It is not intended to provide medical advice or be used solely by the customer in the diagnosis, cure, mitigation, treatment, or prevention of any disease or health condition. If you have serious medical conditions, including but not limited to weight-related issues, diabetes, or heart disease, you should not make changes to your diet or exercise routine without consulting your healthcare provider. Under no circumstances should you modify your medication or medical care without professional medical guidance.

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