Genetic Predisposition
Based on your genetic markers, your predisposition to this trait is shown below
Your Result
Lower Smell sensitivity
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Scientific Evidence
Understanding the Data
- SNP: A specific genetic marker relevant to this trait (e.g., rs2588978)
- Genotype: Your genetic makeup at the given SNP location (e.g., CC)
- Variant allele: The alternative DNA sequence at the SNP site
- Variant allele frequency: Percentage of population carrying this variant
- Variant found: Whether the variant was detected in your DNA file
NCAM1 GeneCards
This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein plays a role in the development of the nervous system by regulating neurogenesis, neurite outgrowth, and cell migration. This protein is also involved in the expansion of T lymphocytes, B lymphocytes and natural killer (NK) cells which play an important role in immune surveillance. This protein plays a role in signal transduction by interacting with fibroblast growth factor receptors, N-cadherin and other components of the extracellular matrix and by triggering signalling cascades involving FYN-focal adhesion kinase (FAK), mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinase (PI3K). One prominent isoform of this gene, cell surface molecule CD56, plays a role in several myeloproliferative disorders such as acute myeloid leukemia and differential expression of this gene is associated with differential disease progression. For example, increased expression of CD56 is correlated with lower survival in acute myeloid leukemia patients whereas increased severity of COVID-19 is correlated with decreased abundance of CD56-expressing NK cells in peripheral blood. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs605843 | T C | T | C | 25.00% | Detected |
TOMM40 GeneCards
The protein encoded by this gene is localized in the outer membrane of the mitochondria. It is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for import of protein precursors into mitochondria. Alternatively spliced transcript variants have been found for this gene.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs2075650 | A G | A | G | 13.00% | Detected |
DHX15 GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs16875528 | -- | T | C | 1.00% | No Data |
PCDH9 GeneCards
This gene encodes a member of the protocadherin family, and cadherin superfamily, of transmembrane proteins containing cadherin domains. These proteins mediate cell adhesion in neural tissues in the presence of calcium. The encoded protein may be involved in signaling at neuronal synaptic junctions. Sharing a characteristic with other protocadherin genes, this gene has a notably large exon that encodes multiple cadherin domains and a transmembrane region. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. COMPLETENESS: complete on the 3' end.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs17252438 | -- | T | C | 6.00% | No Data |
PPM1H GeneCards
protein phosphatase, Mg2+/Mn2+ dependent 1H
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs11174650 | -- | C | T | 8.00% | No Data |
SPON1 GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs12291225 | -- | C | A | 25.00% | No Data |
These are the genetic markers (SNPs) analyzed for this trait. Variations detected in your genome are listed under the "Genotype" column. SNPs showing "--" were not identified in your DNA file.
| SNP | Chromosome | Genotype | Variant Allele | Frequency |
|---|---|---|---|---|
| rs2251885 | 9 | AG | G | 37.00% |
| rs605843 | 11 | TC | C | 25.00% |
| rs2075650 | 19 | AG | G | 13.00% |
| rs4111 | 3 | -- | C | 15.00% |
| rs16875528 | 4 | -- | C | 1.00% |
| rs4865875 | 5 | -- | C | 9.00% |
| rs4715057 | 6 | -- | G | 2.00% |
| rs9321099 | 6 | -- | A | 9.00% |
| rs12291225 | 11 | -- | A | 25.00% |
| rs11174650 | 12 | -- | T | 8.00% |
| rs3751196 | 12 | -- | A | 6.00% |
| rs17252438 | 13 | -- | C | 6.00% |
| rs199443 | 17 | -- | T | 20.00% |
| rs2732614 | 17 | -- | T | 20.00% |
| rs6052484 | 20 | -- | A | 26.00% |
The following peer-reviewed scientific studies support the genetic associations analyzed in this report.
What's Next?
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