Genetic Predisposition
Based on your genetic markers, your predisposition to this trait is shown below
Your Result
Lower Skin youthfulness predisposition
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Scientific Evidence
Understanding the Data
- SNP: A specific genetic marker relevant to this trait (e.g., rs2588978)
- Genotype: Your genetic makeup at the given SNP location (e.g., CC)
- Variant allele: The alternative DNA sequence at the SNP site
- Variant allele frequency: Percentage of population carrying this variant
- Variant found: Whether the variant was detected in your DNA file
MC1R GeneCards
melanocortin 1 receptor
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs4268748 | T C | T | C | 71.00% | Detected |
| rs35096708 | -- | G | A | 11.48% | No Data |
MFHAS1 GeneCards
Identified in a human 8p amplicon, this gene is a potential oncogene whose expression is enhanced in some malignant fibrous histiocytomas (MFH). The primary structure of its product includes an ATP/GTP-binding site, three leucine zipper domains, and a leucine-rich tandem repeat, which are structural or functional elements for interactions among proteins related to the cell cycle, and which suggest that overexpression might be oncogenic with respect to MFH.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs96621 | T C | T | C | 48.12% | Detected |
CERS6 GeneCards
ceramide synthase 6
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs13020412 | -- | A | G | 3.00% | No Data |
DOK6 GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| 18:69333415 | -- | ? | ? | 0.00% | No Data |
ERBB4 GeneCards
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| 2:211327945 | -- | ? | ? | 0.00% | No Data |
IRF4 GeneCards
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs12203592 | -- | C | T | 79.00% | No Data |
RBM43 GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs10445747 | -- | A | G | 2.76% | No Data |
SLC36A2 GeneCards
This gene encodes a pH-dependent proton-coupled amino acid transporter that belongs to the amino acid auxin permease 1 protein family. The encoded protein primarily transports small amino acids such as glycine, alanine and proline. Mutations in this gene are associated with iminoglycinuria and hyperglycinuria.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs428668 | -- | T | C | 47.76% | No Data |
SLC45A2 GeneCards
This gene encodes a transporter protein that mediates melanin synthesis. The protein is expressed in a high percentage of melanoma cell lines. Mutations in this gene are a cause of oculocutaneous albinism type 4, and polymorphisms in this gene are associated with variations in skin and hair color. Multiple transcript variants encoding different isoforms have been found for this gene.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs185146 | -- | C | T | 94.00% | No Data |
USP49 GeneCards
ubiquitin specific peptidase 49
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs12661968 | -- | T | C | 17.35% | No Data |
These are the genetic markers (SNPs) analyzed for this trait. Variations detected in your genome are listed under the "Genotype" column. SNPs showing "--" were not identified in your DNA file.
| SNP | Chromosome | Genotype | Variant Allele | Frequency |
|---|---|---|---|---|
| rs3791406 | 2 | TT | T | 56.71% |
| rs4698048 | 4 | TG | G | 61.00% |
| rs96621 | 8 | TC | C | 48.12% |
| rs4268748 | 16 | TC | C | 71.00% |
| 2:211327945 | -- | ? | 0.00% | |
| 18:69333415 | -- | ? | 0.00% | |
| rs10445747 | 2 | -- | G | 2.76% |
| rs13020412 | 2 | -- | G | 3.00% |
| rs9848726 | 3 | -- | T | 32.27% |
| rs428668 | 5 | -- | C | 47.76% |
| rs185146 | 5 | -- | T | 94.00% |
| rs12203592 | 6 | -- | T | 79.00% |
| rs12661968 | 6 | -- | C | 17.35% |
| rs35096708 | 16 | -- | A | 11.48% |
The following peer-reviewed scientific studies support the genetic associations analyzed in this report.
What's Next?
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