Genetic Predisposition

Based on your genetic markers, your predisposition to this trait is shown below

Your Result

Faster caffeine metabolism in smokers and heavy coffee consumers

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Scientific Evidence

Understanding the Data
  • SNP: A specific genetic marker relevant to this trait (e.g., rs2588978)
  • Genotype: Your genetic makeup at the given SNP location (e.g., CC)
  • Variant allele: The alternative DNA sequence at the SNP site
  • Variant allele frequency: Percentage of population carrying this variant
  • Variant found: Whether the variant was detected in your DNA file
1 gene analyzed 1 with detected variants
Variant Detected

CYP1A2 GeneCards

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008]

Genomic Location
Chr 15 Start: 74,748,845 End: 74,756,607 Build: HG19
Associated SNPs
1 / 1 detected
SNP Genotype Ref. Allele Variant Allele Frequency Status

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Coverage: 3/3 SNPs detected (100%)
Reference: Human Genome Build 37 (HG19)
Generated: March 02, 2026
DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence. Other testing companies may report using the opposite strand, requiring conversion for accurate comparison.