Physical Performance

Muscular endurance

Muscular endurance refers to a muscle's ability to sustain repeated contractions before fatiguing. It depends partly on muscle fiber composition and aerobic capacity.

GWAS and candidate-gene work has identified variants linked to endurance traits, including those near ACTN3 and PPARGC1A.

This result reflects research-level variation in endurance biology and is not a fitness test.

Training, age, body composition, nutrition, sleep, hydration, and recovery strongly shape actual muscular endurance.

3 SNPs

4 Studies

Oct 14, 2026

DEMO REPORT

Your Analysis

Genetic Tendency

Based on your genetic markers, your tendency toward this trait is shown below

Your Result

Slightly increased performance in endurance sports

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Confidence Score

Very high

This score indicates how strongly your genetics predispose you to this trait based on 3/3 SNPs detected.

Trait Influence Breakdown

Genetic

60%

Environment

40%

Scientific Evidence

Understanding the Data

SNP: A specific genetic marker relevant to this trait (e.g., rs2588978)
Genotype: Your genetic makeup at the given SNP location (e.g., CC)
Variant allele: The alternative DNA sequence at the SNP site

Variant allele frequency: Percentage of population carrying this variant
Variant found: Whether the variant was detected in your DNA file

Variant Detected

PPARA GeneCards

Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]

Genomic Location

Chr 22 Start: 46,150,521 End: 46,243,756 Build: HG19

5' end 3' end

Associated SNPs

1 / 1 detected

SNP	Genotype	Ref. Allele	Variant Allele	Frequency	Status
rs4253778	C G	G	C	27.42%	Detected
Your Genotype CG Reference Allele G Variant Allele C Population Frequency 27.42% Variant Status Variant Detected Database Link NCBI dbSNP

These are the genetic markers (SNPs) analyzed for this trait. Variations detected in your genome are listed under the "Genotype" column. SNPs showing "--" were not identified in your DNA file.

SNP	Chromosome	Genotype	Variant Allele	Frequency
rs4253778	22	CG	C	27.42%

DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence (build 37/HG19). Other companies may use the opposite strand, so genotypes may need conversion for comparison.

Important Medical Disclaimer

This report is intended for educational and informational purposes only. It is not intended to provide medical advice or be used solely by the customer in the diagnosis, cure, mitigation, treatment, or prevention of any disease or health condition. If you have serious medical conditions, including but not limited to weight-related issues, diabetes, or heart disease, you should not make changes to your diet or exercise routine without consulting your healthcare provider. Under no circumstances should you modify your medication or medical care without professional medical guidance.

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