Physical Performance

Tendinopathies in lower extremities (legs)

Lower-extremity tendinopathies include patellar, Achilles, and other leg tendon overuse injuries, common in runners and jumpers.

GWAS and candidate-gene work has identified variants near collagen and matrix genes linked to leg tendinopathies.

This result reflects research-level variation in tendon biology and is not a clinical assessment.

Training load, surface, footwear, biomechanics, calf and hip strength, recovery, and prior injury all strongly affect real leg tendon problems.

3 SNPs

1 Study

Oct 14, 2026

DEMO REPORT

Your Analysis

Genetic Tendency

Based on your genetic markers, your tendency toward this trait is shown below

Your Result

Slightly higher tendency of tendinopathies in lower extremities (legs)

Very Low Very High

Was this result accurate for you?

Confidence Score

Very high

This score indicates how strongly your genetics predispose you to this trait based on 3/3 SNPs detected.

Trait Influence Breakdown

Genetic

60%

Environment

40%

Scientific Evidence

Understanding the Data

SNP: A specific genetic marker relevant to this trait (e.g., rs2588978)
Genotype: Your genetic makeup at the given SNP location (e.g., CC)
Variant allele: The alternative DNA sequence at the SNP site

Variant allele frequency: Percentage of population carrying this variant
Variant found: Whether the variant was detected in your DNA file

Variant Detected

COL5A1 GeneCards

This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. The encoded procollagen protein occurs commonly as the heterotrimer pro-alpha1(V)-pro-alpha1(V)-pro-alpha2(V). Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

Genomic Location

Chr 9 Start: 134,641,789 End: 134,844,843 Build: HG19

5' end 3' end

Associated SNPs

1 / 1 detected

SNP	Genotype	Ref. Allele	Variant Allele	Frequency	Status
rs12722	C T	C	T	34.94%	Detected
Your Genotype CT Reference Allele C Variant Allele T Population Frequency 34.94% Variant Status Variant Detected Database Link NCBI dbSNP

These are the genetic markers (SNPs) analyzed for this trait. Variations detected in your genome are listed under the "Genotype" column. SNPs showing "--" were not identified in your DNA file.

SNP	Chromosome	Genotype	Variant Allele	Frequency
rs12722	9	CT	T	34.94%

DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence (build 37/HG19). Other companies may use the opposite strand, so genotypes may need conversion for comparison.

Important Medical Disclaimer

This report is intended for educational and informational purposes only. It is not intended to provide medical advice or be used solely by the customer in the diagnosis, cure, mitigation, treatment, or prevention of any disease or health condition. If you have serious medical conditions, including but not limited to weight-related issues, diabetes, or heart disease, you should not make changes to your diet or exercise routine without consulting your healthcare provider. Under no circumstances should you modify your medication or medical care without professional medical guidance.

Continue Exploring

What's Next?

Compare Samples

Compare this trait across different samples in your account

Compare

Print Report

Download or print this report for your records

Explore More Traits

Discover insights about other genetic traits

Browse Traits

DEMO Sample report with example data. Not your results.