Genetic Predisposition
Based on your genetic markers, your predisposition to this trait is shown below
Your Result
Lower Phoneme awareness performance predisposition
Was this result accurate for you?
Scientific Evidence
Understanding the Data
- SNP: A specific genetic marker relevant to this trait (e.g., rs2588978)
- Genotype: Your genetic makeup at the given SNP location (e.g., CC)
- Variant allele: The alternative DNA sequence at the SNP site
- Variant allele frequency: Percentage of population carrying this variant
- Variant found: Whether the variant was detected in your DNA file
SLC12A3 GeneCards
This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs9925265 | A A | G | A | 53.66% | Detected |
ARMC2 GeneCards
armadillo repeat containing 2
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs11153138 | -- | C | T | 61.73% | No Data |
CACNA2D1 GeneCards
The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs71522613 | -- | TGAA | T | 84.85% | No Data |
LINC00565 GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs73579354 | -- | C | G | 84.89% | No Data |
MECOM GeneCards
The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs11314719 | -- | TA | T | 76.63% | No Data |
PHF21B GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs79661460 | -- | G | A | 93.11% | No Data |
RASA3 GeneCards
RAS p21 protein activator 3
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs74406200 | -- | C | T | 82.09% | No Data |
SEMA6D GeneCards
Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs281238 | -- | T | C | 42.27% | No Data |
TM4SF20 GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs10178861 | -- | G | C | 40.48% | No Data |
These are the genetic markers (SNPs) analyzed for this trait. Variations detected in your genome are listed under the "Genotype" column. SNPs showing "--" were not identified in your DNA file.
| SNP | Chromosome | Genotype | Variant Allele | Frequency |
|---|---|---|---|---|
| rs7645322 | 3 | TC | C | 57.74% |
| rs9925265 | 16 | AA | A | 53.66% |
| rs7515853 | 1 | -- | A | 19.38% |
| rs10178861 | 2 | -- | C | 40.48% |
| rs11314719 | 3 | -- | T | 76.63% |
| rs6888116 | 5 | -- | C | 35.82% |
| rs11153138 | 6 | -- | T | 61.73% |
| rs7769947 | 6 | -- | T | 37.41% |
| rs62446997 | 7 | -- | C | 84.39% |
| rs7783045 | 7 | -- | T | 91.42% |
| rs71522613 | 7 | -- | T | 84.85% |
| rs74406200 | 13 | -- | T | 82.09% |
| rs73579354 | 13 | -- | G | 84.89% |
| rs281238 | 15 | -- | C | 42.27% |
| rs11648635 | 16 | -- | G | 13.20% |
| rs2833870 | 21 | -- | C | 94.12% |
| rs79661460 | 22 | -- | A | 93.11% |
The following peer-reviewed scientific studies support the genetic associations analyzed in this report.
What's Next?
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