Achievement Potential

Stress-response tendency

The "worrier-warrior" idea comes from research on the COMT gene, which influences dopamine breakdown in the prefrontal cortex.

The Val and Met variants in COMT have been associated with subtle differences in cognitive style under stress, with no single profile being globally better or worse.

This result reflects research-level variation in dopamine biology and is not a personality test or a performance prediction.

Stress, sleep, mood, training, task type, and overall health all strongly affect how this biology actually shows up in behavior.

3 SNPs

1 Study

Oct 14, 2026

DEMO REPORT

Your Analysis

Genetic Tendency

Based on your genetic markers, your tendency toward this trait is shown below

Genetic Association

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Intermediate levels of dopamine, intermediate memory performance

Very Low Very High

This is a weak, population-level genetic association, not a personal diagnosis or a definitive trait.

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Confidence Score

Very high

This score indicates how strongly your genetics predispose you to this trait based on 3/3 SNPs detected.

Trait Influence Breakdown

Genetic

60%

Environment

40%

Scientific Evidence

Understanding the Data

SNP: A specific genetic marker relevant to this trait (e.g., rs2588978)
Genotype: Your genetic makeup at the given SNP location (e.g., CC)
Variant allele: The alternative DNA sequence at the SNP site

Variant allele frequency: Percentage of population carrying this variant
Variant found: Whether the variant was detected in your DNA file

Variant Detected

COMT GeneCards

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]

Genomic Location

Chr 22 Start: 19,941,371 End: 19,969,975 Build: HG19

5' end 3' end

Associated SNPs

1 / 1 detected

SNP	Genotype	Ref. Allele	Variant Allele	Frequency	Status
rs4680	A A	G	A	36.92%	Detected
Your Genotype AA Reference Allele G Variant Allele A Population Frequency 36.92% Variant Status Variant Detected Database Link NCBI dbSNP

These are the genetic markers (SNPs) analyzed for this trait. Variations detected in your genome are listed under the "Genotype" column. SNPs showing "--" were not identified in your DNA file.

SNP	Chromosome	Genotype	Variant Allele	Frequency
rs4680	22	AA	A	36.92%

DNA Genics reports genotypes based on the 'positive' strand of the human genome reference sequence (build 37/HG19). Other companies may use the opposite strand, so genotypes may need conversion for comparison.

The following peer-reviewed scientific studies support the genetic associations analyzed in this report.

Common Kibra alleles are associated with human memory performance

Evidence

10/20/2006

Science

Authors: Papassotiropoulos A, Stephan DA, Huentelman MJ, Hoerndli FJ, Craig DW, Pearson JV, Huynh KD, Brunner F, Corneveaux J, Osborne D, Wollmer MA, Aerni A, Coluccia D, Hänggi J, Mondadori CR, Buchmann A, Reiman EM, Caselli RJ, Henke K, de Quervain DJ

18 individuals (african american or afro-caribbean, hispanic or latin american, asian unspecified, native american ancestry)

Important Medical Disclaimer

This report is intended for educational and informational purposes only. It is not intended to provide medical advice or be used solely by the customer in the diagnosis, cure, mitigation, treatment, or prevention of any disease or health condition. If you have serious medical conditions, including but not limited to weight-related issues, diabetes, or heart disease, you should not make changes to your diet or exercise routine without consulting your healthcare provider. Under no circumstances should you modify your medication or medical care without professional medical guidance.

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