Genetic Predisposition
Based on your genetic markers, your predisposition to this trait is shown below
Your Result
Average genetic predisposition
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Scientific Evidence
Understanding the Data
- SNP: A specific genetic marker relevant to this trait (e.g., rs2588978)
- Genotype: Your genetic makeup at the given SNP location (e.g., CC)
- Variant allele: The alternative DNA sequence at the SNP site
- Variant allele frequency: Percentage of population carrying this variant
- Variant found: Whether the variant was detected in your DNA file
CCDC170 GeneCards
The function of this gene and its encoded protein is not known. Several genome-wide association studies have implicated the region around this gene to be involved in breast cancer and bone mineral density, but no link to this specific gene has been found.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs4869742 | C T | C | T | 70.88% | Detected |
WNT16 GeneCards
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs2908007 | A G | A | G | 59.61% | Detected |
AQP1 GeneCards
This gene encodes a small integral membrane protein with six bilayer spanning domains that functions as a water channel protein. This protein permits passive transport of water along an osmotic gradient. This gene is a possible candidate for disorders involving imbalance in ocular fluid movement.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs10276670 | -- | A | G | 77.24% | No Data |
FGFRL1 GeneCards
fibroblast growth factor receptor like 1
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs111632154 | -- | T | C | 95.72% | No Data |
| rs78520297 | -- | T | C | 85.07% | No Data |
MBL2 GeneCards
This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes and binds to mannose and N-acetylglucosamine on many microorganisms, including bacteria, yeast, and viruses including influenza virus, HIV and SARS-CoV. This binding activates the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs11003048 | -- | C | G | 89.53% | No Data |
PPP6R3 GeneCards
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs35989399 | -- | C | T | 84.38% | No Data |
SLC8A1 GeneCards
solute carrier family 8 member A1
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs10490045 | -- | T | C | 77.39% | No Data |
SOST GeneCards
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
Genomic Location
Associated SNPs
| SNP | Genotype | Ref. Allele | Variant Allele | Frequency | Status |
|---|---|---|---|---|---|
| rs4793022 | -- | G | C | 60.96% | No Data |
These are the genetic markers (SNPs) analyzed for this trait. Variations detected in your genome are listed under the "Genotype" column. SNPs showing "--" were not identified in your DNA file.
| SNP | Chromosome | Genotype | Variant Allele | Frequency |
|---|---|---|---|---|
| rs4869742 | 6 | CT | T | 70.88% |
| rs6963134 | 7 | GG | G | 34.73% |
| rs2908007 | 7 | AG | G | 59.61% |
| rs4796995 | 18 | AG | G | 63.14% |
| rs2836789 | 21 | CT | T | 28.45% |
| rs10490045 | 2 | -- | C | 77.39% |
| rs111632154 | 4 | -- | C | 95.72% |
| rs78520297 | 4 | -- | C | 85.07% |
| rs7741021 | 6 | -- | C | 53.46% |
| rs10276670 | 7 | -- | G | 77.24% |
| rs11003048 | 10 | -- | G | 89.53% |
| rs576679 | 11 | -- | A | 68.49% |
| rs35989399 | 11 | -- | T | 84.38% |
| rs4793022 | 17 | -- | C | 60.96% |
The following peer-reviewed scientific studies support the genetic associations analyzed in this report.
What's Next?
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