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GWAS 2021-12-02

Genome-Wide Association and Mendelian Randomization Analysis Reveal the Causal Relationship Between White Blood Cell Subtypes and Asthma in Africans.

Soremekun O, Soremekun C et al.

Front Genet

White blood cell (WBC) traits and their subtypes such as basophil count (Bas), eosinophil count (Eos...

Monocyte count

16152

Participants

N/A

Studies

Details PubMed

GWAS 2021-09-27

Whole-genome sequencing in diverse subjects identifies genetic correlates of leukocyte traits: The NHLBI TOPMed program.

Mikhaylova AV, McHugh CP et al.

Am J Hum Genet

Many common and rare variants associated with hematologic traits have been discovered through imputa...

White blood cell count

Replicated

260928

Participants

N/A

Studies

Details PubMed

GWAS 2020-09-01

Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.

Chen MH, Raffield LM et al.

Cell

Most loci identified by GWASs have been found in populations of European ancestry (EUR). In trans-et...

Basophil count

11502

Participants

N/A

Studies

Details PubMed

GWAS 2017-02-01

Genome-wide association of white blood cell counts in Hispanic/Latino Americans: the Hispanic Community Health Study/Study of Latinos.

Jain D, Hodonsky CJ et al.

Hum Mol Genet

Circulating white blood cell (WBC) counts (neutrophils, monocytes, lymphocytes, eosinophils, basophi...

White blood cell count

Replicated

19009

Participants

N/A

Studies

Details PubMed

GWAS 2016-12-28

Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms.

Guo MH, Nandakumar SK et al.

Proc Natl Acad Sci U S A

Genetic variants affecting hematopoiesis can influence commonly measured blood cell traits. To ident...

Basophil count

5578

Participants

N/A

Studies

Details PubMed

GWAS 2011-07-01

Multiple loci are associated with white blood cell phenotypes.

Nalls MA, Couper DJ et al.

PLoS Genet

White blood cell (WBC) count is a common clinical measure from complete blood count assays, and it v...

White blood cell count

Replicated

31332

Participants

N/A

Studies

Details PubMed

GWAS 2011-06-30

Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.

Okada Y, Hirota T et al.

PLoS Genet

White blood cells (WBCs) mediate immune systems and consist of various subtypes with distinct roles....

White blood cell types

Replicated

14792

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genome-Wide Association and Mendelian Randomization Analysis Reveal the Causal Relationship Between White Blood Cell Subtypes and Asthma in Africans.

Soremekun O, Soremekun C et al.

Front Genet

Monocyte count

2021-12-02

Whole-genome sequencing in diverse subjects identifies genetic correlates of leukocyte traits: The NHLBI TOPMed program.

Mikhaylova AV, McHugh CP et al.

Am J Hum Genet

White blood cell count

2021-09-27

Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.

Chen MH, Raffield LM et al.

Cell

Basophil count

2020-09-01

Genome-wide association of white blood cell counts in Hispanic/Latino Americans: the Hispanic Community Health Study/Study of Latinos.

Jain D, Hodonsky CJ et al.

Hum Mol Genet

White blood cell count

2017-02-01

Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms.

Guo MH, Nandakumar SK et al.

Proc Natl Acad Sci U S A

Basophil count

2016-12-28

Multiple loci are associated with white blood cell phenotypes.

Nalls MA, Couper DJ et al.

PLoS Genet

White blood cell count

2011-07-01

Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.

Okada Y, Hirota T et al.

PLoS Genet

White blood cell types

2011-06-30