Active: Cardiometabolic traits Clear all

GWAS 2025-02-19

Plasma proteome variation and its genetic determinants in children and adolescents.

Niu L, Stinson SE et al.

Nat Genet

Our current understanding of the determinants of plasma proteome variation during pediatric developm...

LAD1 protein levels

1909

Participants

N/A

Studies

Details PubMed

GWAS 2024-03-09

A genome-wide association study based on the China Kadoorie Biobank identifies genetic associations between snoring and cardiometabolic traits.

Zhu Y, Zhuang Z et al.

Commun Biol

Despite the high prevalence of snoring in Asia, little is known about the genetic etiology of snorin...

Snoring

100626

Participants

N/A

Studies

Details PubMed

GWAS 2023-10-18

A Cross-ancestry genome-wide meta-analysis, fine-mapping, and gene prioritization approach to characterize the genetic architecture of adiponectin.

Sarsani V, Brotman SM et al.

HGG Adv

Previous genome-wide association studies (GWASs) for adiponectin, a complex trait linked to type 2 d...

Adiponectin levels

Replicated

81993

Participants

N/A

Studies

Details PubMed

GWAS 2022-11-19

The link between liver fat and cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body composition.

van der Meer D, Gurholt TP et al.

Commun Biol

Obesity and associated morbidities, metabolic associated fatty liver disease (MAFLD) included, const...

Abdominal subcutaneous adipose tissue

33532

Participants

N/A

Studies

Details PubMed

GWAS 2022-11-14

Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure.

Levin MG, Tsao NL et al.

Nat Commun

Heart failure is a leading cause of cardiovascular morbidity and mortality. However, the contributio...

Heart failure

Replicated

1993552

Participants

N/A

Studies

Details PubMed

GWAS 2022-11-14

Pleiotropic genetic architecture and novel loci for C-reactive protein levels.

Koskeridis F, Evangelou E et al.

Nat Commun

C-reactive protein is involved in a plethora of pathophysiological conditions. Many genetic loci ass...

C-reactive protein levels (MTAG)

575531

Participants

N/A

Studies

Details PubMed

GWAS 2022-11-09

Identifying causal serum protein-cardiometabolic trait relationships using whole genome sequencing.

Png G, Gerlini R et al.

Hum Mol Genet

Cardiometabolic diseases, such as type 2 diabetes and cardiovascular disease, have a high public hea...

Junctional adhesion molecule A levels

2923

Participants

N/A

Studies

Details PubMed

GWAS 2021-10-07

Genome-wide analyses of multiple obesity-related cytokines and hormones informs biology of cardiometabolic traits.

Meeks KAC, Bentley AR et al.

Genome Med

A complex set of perturbations occur in cytokines and hormones in the etiopathogenesis of obesity an...

Interleukin-1-receptor antagonist levels

Replicated

923

Participants

N/A

Studies

Details PubMed

GWAS 2021-02-04

Multi-trait association studies discover pleiotropic loci between Alzheimer's disease and cardiometabolic traits.

Bone WP, Siewert KM et al.

Alzheimers Res Ther

Identification of genetic risk factors that are shared between Alzheimer's disease (AD) and other tr...

Alzheimer's disease or body fat percentage (pleiotropy)

555974

Participants

N/A

Studies

Details PubMed

GWAS 2020-06-22

Genome-wide associations of human gut microbiome variation and implications for causal inference analyses.

Hughes DA, Bacigalupe R et al.

Nat Microbiol

Recent population-based1-4 and clinical studies5 have identified a range of factors associated with ...

Gut microbiota (bacterial taxa, hurdle binary method)

Replicated

3890

Participants

N/A

Studies

Details PubMed

GWAS 2019-10-02

Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.

Tin A, Marten J et al.

Nat Genet

Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via poorly unders...

Urate levels

457690

Participants

N/A

Studies

Details PubMed

GWAS 2019-10-01

Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa.

Gurdasani D, Carstensen T et al.

Cell

Genomic studies in African populations provide unique opportunities to understand disease etiology, ...

Eosinophil count

7526

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Plasma proteome variation and its genetic determinants in children and adolescents.

Niu L, Stinson SE et al.

Nat Genet

LAD1 protein levels

2025-02-19

A genome-wide association study based on the China Kadoorie Biobank identifies genetic associations between snoring and cardiometabolic traits.

Zhu Y, Zhuang Z et al.

Commun Biol

Snoring

2024-03-09

A Cross-ancestry genome-wide meta-analysis, fine-mapping, and gene prioritization approach to characterize the genetic architecture of adiponectin.

Sarsani V, Brotman SM et al.

HGG Adv

Adiponectin levels

2023-10-18

The link between liver fat and cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body composition.

van der Meer D, Gurholt TP et al.

Commun Biol

Abdominal subcutaneous adipose tissue

2022-11-19

Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure.

Levin MG, Tsao NL et al.

Nat Commun

Heart failure

2022-11-14

Pleiotropic genetic architecture and novel loci for C-reactive protein levels.

Koskeridis F, Evangelou E et al.

Nat Commun

C-reactive protein levels (MTAG)

2022-11-14

Identifying causal serum protein-cardiometabolic trait relationships using whole genome sequencing.

Png G, Gerlini R et al.

Hum Mol Genet

Junctional adhesion molecule A levels

2022-11-09

Genome-wide analyses of multiple obesity-related cytokines and hormones informs biology of cardiometabolic traits.

Meeks KAC, Bentley AR et al.

Genome Med

Interleukin-1-receptor antagonist levels

2021-10-07

Multi-trait association studies discover pleiotropic loci between Alzheimer's disease and cardiometabolic traits.

Bone WP, Siewert KM et al.

Alzheimers Res Ther

Alzheimer's disease or body fat percentage (pleiotropy)

2021-02-04

Genome-wide associations of human gut microbiome variation and implications for causal inference analyses.

Hughes DA, Bacigalupe R et al.

Nat Microbiol

Gut microbiota (bacterial taxa, hurdle binary method)

2020-06-22

Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.

Tin A, Marten J et al.

Nat Genet

Urate levels

2019-10-02

Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa.

Gurdasani D, Carstensen T et al.

Cell

Eosinophil count

2019-10-01