Genome-wide analyses of multiple obesity-related cytokines and hormones informs biology of cardiometabolic traits.
Meeks KAC, Bentley AR, Gouveia MH et al.
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Abstract
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A complex set of perturbations occur in cytokines and hormones in the etiopathogenesis of obesity and related cardiometabolic conditions such as type 2 diabetes (T2D). Evidence for the genetic regulation of these cytokines and hormones is limited, particularly in African-ancestry populations. In order to improve our understanding of the biology of cardiometabolic traits, we investigated the genetic architecture of a large panel of obesity- related cytokines and hormones among Africans with replication analyses in African Americans.
532 Sub-Saharan African ancestry men
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