Active: Corneal curvature Clear all

GWAS 2020-03-19

Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error.

Fan Q, Pozarickij A et al.

Commun Biol

Corneal curvature, a highly heritable trait, is a key clinical endophenotype for myopia - a major ca...

Corneal curvature

Replicated

132260

Participants

N/A

Studies

Details PubMed

GWAS 2018-09-11

Association analysis of exome variants and refraction, axial length, and corneal curvature in a European-American population.

Vergara C, Bomotti SM et al.

Hum Mutat

Refractive errors, myopia, and hyperopia are common visual disorders greatly affecting older individ...

Axial length

874

Participants

N/A

Studies

Details PubMed

GWAS 2015-03-31

Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia.

Miyake M, Yamashiro K et al.

Nat Commun

Myopia can cause severe visual impairment. Here, we report a two-stage genome-wide association study...

Axial length

Replicated

6708

Participants

N/A

Studies

Details PubMed

GWAS 2014-06-24

CMPK1 and RBP3 are associated with corneal curvature in Asian populations.

Chen P, Miyake M et al.

Hum Mol Genet

Corneal curvature (CC) measures the steepness of the cornea and is an important parameter for clinic...

Corneal curvature

Replicated

12660

Participants

N/A

Studies

Details PubMed

GWAS 2013-06-06

Interrogation of the platelet-derived growth factor receptor alpha locus and corneal astigmatism in Australians of Northern European ancestry: results of a genome-wide association study.

Yazar S, Mishra A et al.

Mol Vis

Purpose: Corneal astigmatism is a common eye disorder characterized by irregularities in corneal cur...

Corneal astigmatism

2784

Participants

N/A

Studies

Details PubMed

GWAS 2013-01-03

A genome-wide association study for corneal curvature identifies the platelet-derived growth factor receptor α gene as a quantitative trait locus for eye size in white Europeans.

Guggenheim JA, McMahon G et al.

Mol Vis

Purpose: Corneal curvature is a key determinant of the refractive power of the eye. Variants in two ...

Corneal curvature

Replicated

9383

Participants

N/A

Studies

Details PubMed

GWAS 2012-09-13

Genetic variants near PDGFRA are associated with corneal curvature in Australians.

Mishra A, Yazar S et al.

Invest Ophthalmol Vis Sci

Purpose: Irregularity in the corneal curvature (CC) is highly associated with various eye disorders ...

Corneal curvature

2801

Participants

N/A

Studies

Details PubMed

GWAS 2011-06-10

Association of variants in FRAP1 and PDGFRA with corneal curvature in Asian populations from Singapore.

Han S, Chen P et al.

Hum Mol Genet

Corneal curvature (CC) is a key determinant of major eye diseases, such as keratoconus, myopia and c...

Corneal curvature

Replicated

7360

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error.

Fan Q, Pozarickij A et al.

Commun Biol

Corneal curvature

2020-03-19

Association analysis of exome variants and refraction, axial length, and corneal curvature in a European-American population.

Vergara C, Bomotti SM et al.

Hum Mutat

Axial length

2018-09-11

Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia.

Miyake M, Yamashiro K et al.

Nat Commun

Axial length

2015-03-31

CMPK1 and RBP3 are associated with corneal curvature in Asian populations.

Chen P, Miyake M et al.

Hum Mol Genet

Corneal curvature

2014-06-24

Interrogation of the platelet-derived growth factor receptor alpha locus and corneal astigmatism in Australians of Northern European ancestry: results of a genome-wide association study.

Yazar S, Mishra A et al.

Mol Vis

Corneal astigmatism

2013-06-06

A genome-wide association study for corneal curvature identifies the platelet-derived growth factor receptor α gene as a quantitative trait locus for eye size in white Europeans.

Guggenheim JA, McMahon G et al.

Mol Vis

Corneal curvature

2013-01-03

Genetic variants near PDGFRA are associated with corneal curvature in Australians.

Mishra A, Yazar S et al.

Invest Ophthalmol Vis Sci

Corneal curvature

2012-09-13

Association of variants in FRAP1 and PDGFRA with corneal curvature in Asian populations from Singapore.

Han S, Chen P et al.

Hum Mol Genet

Corneal curvature

2011-06-10