Active: Crohn's disease Clear all

GWAS 2025-01-10

The genomic architecture of circulating cytokine levels points to drug targets for immune-related diseases.

Konieczny MJ, Omarov M et al.

Commun Biol

Circulating cytokines orchestrate immune reactions and are promising drug targets for immune-mediate...

CCL2 protein levels

74783

Participants

N/A

Studies

Details PubMed

GWAS 2025-01-01

Joint analysis of genome-wide cross-trait and multi-omics reveals molecular mechanisms of inflammatory bowel disease and nominates its novel therapeutic genes.

Zhu Z, Wei R et al.

FASEB J

Inflammatory bowel disease (IBD) with the two predominant endophenotypes-Crohn's disease (CD) and ul...

Inflammatory bowel disease (MTAG)

82967

Participants

N/A

Studies

Details PubMed

GWAS 2023-07-31

Regulatory Variants on the Leukocyte Immunoglobulin-Like Receptor Gene Cluster are Associated with Crohn's Disease and Interact with Regulatory Variants for TAP2.

Kim K, Oh SJ et al.

J Crohns Colitis

Background and aims: Crohn's disease [CD] has a complex polygenic aetiology with high heritability. ...

Crohn's disease

79121

Participants

N/A

Studies

Details PubMed

GWAS 2023-07-17

HLA-DQA1*05 and upstream variants of PPARGC1B are associated with infliximab persistence in Japanese Crohn's disease patients.

Shimoda F, Naito T et al.

Pharmacogenomics J

Recently, the HLA-DQA1*05 (rs2097432) genetic variation has been reported to be linked to early infl...

Infliximab persistence in Crohn's disease

Participants

N/A

Studies

Details PubMed

GWAS 2023-05-08

Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries.

Liu Z, Liu R et al.

Nat Genet

Inflammatory bowel diseases (IBDs) are chronic disorders of the gastrointestinal tract with the foll...

Inflammatory bowel disease

398668

Participants

N/A

Studies

Details PubMed

GWAS 2022-09-26

Case-case genome-wide association analysis identifying genetic loci with divergent effects on Crohn's disease and ulcerative colitis.

Jung S, Kim Y et al.

Hum Mol Genet

Crohn's disease (CD) and ulcerative colitis (UC), two major subtypes of inflammatory bowel disease, ...

Crohn's disease vs ulcerative colitis

Replicated

5925

Participants

N/A

Studies

Details PubMed

GWAS 2022-06-24

Identification of healthspan-promoting genes in Caenorhabditis elegans based on a human GWAS study.

Saul N, Dhondt I et al.

Biogerontology

To find drivers of healthy ageing, a genome-wide association study (GWAS) was performed in healthy a...

Increased healthspan in old age

2252

Participants

N/A

Studies

Details PubMed

GWAS 2022-05-05

Identification of shared loci associated with both Crohn's disease and leprosy in east Asians.

Jung S, Park D et al.

Hum Mol Genet

Genome-wide association studies (GWAS) of Crohn's disease (CD) in European and leprosy in Chinese po...

Crohn's disease

Replicated

7266

Participants

N/A

Studies

Details PubMed

GWAS 2022-04-12

A genome-wide screen for variants influencing certolizumab pegol response in a moderate to severe rheumatoid arthritis population.

White IR, Kleinstein SE et al.

PLoS One

Certolizumab pegol (CZP) is a PEGylated Fc-free tumor necrosis factor (TNF) inhibitor antibody appro...

Certolizumab pegol response in rheumatoid arthritis (20% symptom reduction at 6 weeks)

302

Participants

N/A

Studies

Details PubMed

GWAS 2022-03-01

Local genetic variation of inflammatory bowel disease in Basque population and its effect in risk prediction.

Garcia-Etxebarria K, Merino O et al.

Sci Rep

Inflammatory bowel disease (IBD) is characterised by chronic inflammation of the gastrointestinal tr...

Inflammatory bowel disease

1433

Participants

N/A

Studies

Details PubMed

GWAS 2021-09-20

GWAS META-analysis followed by MENDELIAN randomisation revealed potential control mechanisms for circulating α-klotho levels.

Gergei I, Zheng J et al.

Hum Mol Genet

The protein α-Klotho acts as transmembrane co-receptor for fibroblast growth factor 23 (FGF23) and i...

Circulating plasma alpha-Klotho levels

4376

Participants

N/A

Studies

Details PubMed

GWAS 2021-03-16

Novel Genetic Variant Predicts Surgical Recurrence Risk in Crohn's Disease Patients.

Wang MH, Friton JJ et al.

Inflamm Bowel Dis

We aimed to identify a model of clinical and genetic risk factors through hypothesis-free search acr...

Surgical recurrence in Crohn's disease

372

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

The genomic architecture of circulating cytokine levels points to drug targets for immune-related diseases.

Konieczny MJ, Omarov M et al.

Commun Biol

CCL2 protein levels

2025-01-10

Joint analysis of genome-wide cross-trait and multi-omics reveals molecular mechanisms of inflammatory bowel disease and nominates its novel therapeutic genes.

Zhu Z, Wei R et al.

FASEB J

Inflammatory bowel disease (MTAG)

2025-01-01

Regulatory Variants on the Leukocyte Immunoglobulin-Like Receptor Gene Cluster are Associated with Crohn's Disease and Interact with Regulatory Variants for TAP2.

Kim K, Oh SJ et al.

J Crohns Colitis

Crohn's disease

2023-07-31

HLA-DQA1*05 and upstream variants of PPARGC1B are associated with infliximab persistence in Japanese Crohn's disease patients.

Shimoda F, Naito T et al.

Pharmacogenomics J

Infliximab persistence in Crohn's disease

2023-07-17

Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries.

Liu Z, Liu R et al.

Nat Genet

Inflammatory bowel disease

2023-05-08

Case-case genome-wide association analysis identifying genetic loci with divergent effects on Crohn's disease and ulcerative colitis.

Jung S, Kim Y et al.

Hum Mol Genet

Crohn's disease vs ulcerative colitis

2022-09-26

Identification of healthspan-promoting genes in Caenorhabditis elegans based on a human GWAS study.

Saul N, Dhondt I et al.

Biogerontology

Increased healthspan in old age

2022-06-24

Identification of shared loci associated with both Crohn's disease and leprosy in east Asians.

Jung S, Park D et al.

Hum Mol Genet

Crohn's disease

2022-05-05

A genome-wide screen for variants influencing certolizumab pegol response in a moderate to severe rheumatoid arthritis population.

White IR, Kleinstein SE et al.

PLoS One

Certolizumab pegol response in rheumatoid arthritis (20% symptom reduction at 6 weeks)

2022-04-12

Local genetic variation of inflammatory bowel disease in Basque population and its effect in risk prediction.

Garcia-Etxebarria K, Merino O et al.

Sci Rep

Inflammatory bowel disease

2022-03-01

GWAS META-analysis followed by MENDELIAN randomisation revealed potential control mechanisms for circulating α-klotho levels.

Gergei I, Zheng J et al.

Hum Mol Genet

Circulating plasma alpha-Klotho levels

2021-09-20

Novel Genetic Variant Predicts Surgical Recurrence Risk in Crohn's Disease Patients.

Wang MH, Friton JJ et al.

Inflamm Bowel Dis

Surgical recurrence in Crohn's disease

2021-03-16