Active: Drinking behavior Clear all

GWAS 2024-01-26

Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people.

Koyanagi YN, Nakatochi M et al.

Sci Adv

An East Asian-specific variant on aldehyde dehydrogenase 2 (ALDH2 rs671, G>A) is the major geneti...

Daily alcohol intake in rs671 GG genotype

87980

Participants

N/A

Studies

Details PubMed

GWAS 2022-10-03

Genome-Wide Investigation of Maximum Habitual Alcohol Intake in US Veterans in Relation to Alcohol Consumption Traits and Alcohol Use Disorder.

Deak JD, Levey DF et al.

JAMA Netw Open

Importance: Alcohol genome-wide association studies (GWASs) have generally focused on alcohol consum...

Maximum habitual alcohol consumption

247755

Participants

N/A

Studies

Details PubMed

GWAS 2021-09-17

The Aldehyde Dehydrogenase ALDH2*2 Allele, Associated with Alcohol Drinking Behavior, Dates Back to Prehistoric Times.

Lin CL, Chien RN et al.

Biomolecules

Human alcohol-consumption behavior is partly genetically encoded. The alcohol consumption of 987 res...

Hazardous alcohol drinking

197

Participants

N/A

Studies

Details PubMed

GWAS 2021-05-24

<i>ALDH2</i> p.E504K Variation and Sex Are Major Factors Associated with Current and Quitting Alcohol Drinking in Japanese Oldest Old.

Sasaki T, Nishimoto Y et al.

Genes (Basel)

This study identified the factors associated with current and quitting alcohol drinking in the Oldes...

Alcohol drinking status (current drinker vs non-current drinker)

1015

Participants

N/A

Studies

Details PubMed

GWAS 2020-10-01

ALDH2 genotype modulates the association between alcohol consumption and AST/ALT ratio among middle-aged Japanese men: a genome-wide G × E interaction analysis.

Sutoh Y, Hachiya T et al.

Sci Rep

Liver tests (LT), especially to measure AST, ALT and GGT levels, are widely used to evaluate the ris...

Aspartate aminotransferase levels x alcohol consumption interaction

Replicated

12244

Participants

N/A

Studies

Details PubMed

GWAS 2018-11-26

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders.

Walters RK, Polimanti R et al.

Nat Neurosci

Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic a...

Alcohol dependence

Replicated

80898

Participants

N/A

Studies

Details PubMed

GWAS 2016-11-28

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference.

Schumann G, Liu C et al.

Proc Natl Acad Sci U S A

Excessive alcohol consumption is a major public health problem worldwide. Although drinking habits a...

Alcohol consumption

Replicated

105898

Participants

N/A

Studies

Details PubMed

GWAS 2013-01-30

Common variants at 12q24 are associated with drinking behavior in Han Chinese.

Yang X, Lu X et al.

Am J Clin Nutr

Alcohol consumption is heritable, but genetic susceptibility to drinking behavior has not been inves...

Drinking behavior

Replicated

23199

Participants

N/A

Studies

Details PubMed

GWAS 2012-03-01

ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior.

Chen XD, Xiong DH et al.

Chin Med J (Engl)

Alcohol dependence (AD) is a complex disorder characterized by impaired control over drinking. It is...

Drinking behavior

Replicated

6592

Participants

N/A

Studies

Details PubMed

GWAS 2011-04-06

Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption.

Schumann G, Coin LJ et al.

Proc Natl Acad Sci U S A

Alcohol consumption is a moderately heritable trait, but the genetic basis in humans is largely unkn...

Alcohol consumption

Replicated

47501

Participants

N/A

Studies

Details PubMed

GWAS 2011-03-01

Confirmation of ALDH2 as a Major locus of drinking behavior and of its variants regulating multiple metabolic phenotypes in a Japanese population.

Takeuchi F, Isono M et al.

Circ J

Normative alcohol use (or drinking behavior) influences the risk of cardiovascular disease in a mult...

Drinking behavior

Replicated

7128

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people.

Koyanagi YN, Nakatochi M et al.

Sci Adv

Daily alcohol intake in rs671 GG genotype

2024-01-26

Genome-Wide Investigation of Maximum Habitual Alcohol Intake in US Veterans in Relation to Alcohol Consumption Traits and Alcohol Use Disorder.

Deak JD, Levey DF et al.

JAMA Netw Open

Maximum habitual alcohol consumption

2022-10-03

The Aldehyde Dehydrogenase ALDH2*2 Allele, Associated with Alcohol Drinking Behavior, Dates Back to Prehistoric Times.

Lin CL, Chien RN et al.

Biomolecules

Hazardous alcohol drinking

2021-09-17

<i>ALDH2</i> p.E504K Variation and Sex Are Major Factors Associated with Current and Quitting Alcohol Drinking in Japanese Oldest Old.

Sasaki T, Nishimoto Y et al.

Genes (Basel)

Alcohol drinking status (current drinker vs non-current drinker)

2021-05-24

ALDH2 genotype modulates the association between alcohol consumption and AST/ALT ratio among middle-aged Japanese men: a genome-wide G × E interaction analysis.

Sutoh Y, Hachiya T et al.

Sci Rep

Aspartate aminotransferase levels x alcohol consumption interaction

2020-10-01

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders.

Walters RK, Polimanti R et al.

Nat Neurosci

Alcohol dependence

2018-11-26

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference.

Schumann G, Liu C et al.

Proc Natl Acad Sci U S A

Alcohol consumption

2016-11-28

Common variants at 12q24 are associated with drinking behavior in Han Chinese.

Yang X, Lu X et al.

Am J Clin Nutr

Drinking behavior

2013-01-30

ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior.

Chen XD, Xiong DH et al.

Chin Med J (Engl)

Drinking behavior

2012-03-01

Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption.

Schumann G, Coin LJ et al.

Proc Natl Acad Sci U S A

Alcohol consumption

2011-04-06

Confirmation of ALDH2 as a Major locus of drinking behavior and of its variants regulating multiple metabolic phenotypes in a Japanese population.

Takeuchi F, Isono M et al.

Circ J

Drinking behavior

2011-03-01