Active: End-stage renal disease Clear all

GWAS 2022-10-21

Nidogen-1 could play a role in diabetic kidney disease development in type 2 diabetes: a genome-wide association meta-analysis.

Khattab A, Torkamani A

Hum Genomics

Diabetic kidney disease (DKD) affects about 40% of patients with diabetes. It is incurable and usual...

Diabetic kidney disease in type 2 diabetes

13123

Participants

N/A

Studies

Details PubMed

GWAS 2022-09-20

Diverse ancestry whole-genome sequencing association study identifies TBX5 and PTK7 as susceptibility genes for posterior urethral valves.

Chan MMY, Sadeghi-Alavijeh O et al.

Elife

Posterior urethral valves (PUV) are the commonest cause of end-stage renal disease in children, but ...

Posterior urethral valves

Replicated

23859

Participants

N/A

Studies

Details PubMed

GWAS 2022-06-28

Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease.

Sandholm N, Cole JB et al.

Diabetologia

Aims/hypothesis: Diabetic kidney disease (DKD) is the leading cause of kidney failure and has a subs...

Kidney disese (macroalbuminuria or end-stage renal disease) in diabetes

22134

Participants

N/A

Studies

Details PubMed

GWAS 2021-06-14

Variants in BANK1 are associated with lupus nephritis of European ancestry.

Bolin K, Imgenberg-Kreuz J et al.

Genes Immun

The genetic background of lupus nephritis (LN) has not been completely elucidated. We performed a ca...

Lupus nephritis in systemic lupus erythematosus

Replicated

2886

Participants

N/A

Studies

Details PubMed

GWAS 2018-12-13

A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria.

Ahluwalia TS, Schulz CA et al.

Diabetologia

Aims/hypothesis: Identifying rare coding variants associated with albuminuria may open new avenues f...

Albuminuria

Replicated

36590

Participants

N/A

Studies

Details PubMed

GWAS 2018-06-06

Genome-wide association studies suggest that APOL1-environment interactions more likely trigger kidney disease in African Americans with nondiabetic nephropathy than strong APOL1-second gene interactions.

Langefeld CD, Comeau ME et al.

Kidney Int

African Americans carrying two apolipoprotein L1 gene (APOL1) renal risk variants have a high risk f...

End stage renal disease x APOL1 genotype interaction

2649

Participants

N/A

Studies

Details PubMed

GWAS 2018-03-23

Genetic markers for urine haptoglobin is associated with decline in renal function in type 2 diabetes in East Asians.

Gurung RL, Dorajoo R et al.

Sci Rep

Urine haptoglobin (uHP) level prospectively predicts diabetic kidney disease (DKD) progression. Here...

Urinary haptoglobin levels in type 2 diabetes

Replicated

805

Participants

N/A

Studies

Details PubMed

GWAS 2015-12-02

Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.

Teumer A, Tin A et al.

Diabetes

Elevated concentrations of albumin in the urine, albuminuria, are a hallmark of diabetic kidney dise...

Urinary albumin-to-creatinine ratio in diabetes

Replicated

7787

Participants

N/A

Studies

Details PubMed

GWAS 2015-09-28

Genetic loci associated with renal function measures and chronic kidney disease in children: the Pediatric Investigation for Genetic Factors Linked with Renal Progression Consortium.

Wuttke M, Wong CS et al.

Nephrol Dial Transplant

Chronic kidney disease (CKD) in children is characterized by rapid progression and a high incidence ...

Proteinuria in chronic kidney disease

1141

Participants

N/A

Studies

Details PubMed

GWAS 2014-05-29

Novel genetic susceptibility loci for diabetic end-stage renal disease identified through robust naive Bayes classification.

Sambo F, Malovini A et al.

Diabetologia

Aims/hypothesis: Diabetic nephropathy is a major diabetic complication, and diabetes is the leading ...

End-stage renal disease or diabetic nephropathy in type 1 diabetes

Replicated

7727

Participants

N/A

Studies

Details PubMed

GWAS 2013-09-12

Chromosome 2q31.1 associates with ESRD in women with type 1 diabetes.

Sandholm N, McKnight AJ et al.

J Am Soc Nephrol

Sex and genetic variation influence the risk of developing diabetic nephropathy and ESRD in patients...

End-stage renal disease in Type 1 diabetics

Replicated

5081

Participants

N/A

Studies

Details PubMed

GWAS 2012-09-20

New susceptibility loci associated with kidney disease in type 1 diabetes.

Sandholm N, Salem RM et al.

PLoS Genet

Diabetic kidney disease, or diabetic nephropathy (DN), is a major complication of diabetes and the l...

Type 1 diabetes nephropathy

Replicated

10915

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Nidogen-1 could play a role in diabetic kidney disease development in type 2 diabetes: a genome-wide association meta-analysis.

Khattab A, Torkamani A

Hum Genomics

Diabetic kidney disease in type 2 diabetes

2022-10-21

Diverse ancestry whole-genome sequencing association study identifies TBX5 and PTK7 as susceptibility genes for posterior urethral valves.

Chan MMY, Sadeghi-Alavijeh O et al.

Elife

Posterior urethral valves

2022-09-20

Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease.

Sandholm N, Cole JB et al.

Diabetologia

Kidney disese (macroalbuminuria or end-stage renal disease) in diabetes

2022-06-28

Variants in BANK1 are associated with lupus nephritis of European ancestry.

Bolin K, Imgenberg-Kreuz J et al.

Genes Immun

Lupus nephritis in systemic lupus erythematosus

2021-06-14

A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria.

Ahluwalia TS, Schulz CA et al.

Diabetologia

Albuminuria

2018-12-13

Genome-wide association studies suggest that APOL1-environment interactions more likely trigger kidney disease in African Americans with nondiabetic nephropathy than strong APOL1-second gene interactions.

Langefeld CD, Comeau ME et al.

Kidney Int

End stage renal disease x APOL1 genotype interaction

2018-06-06

Genetic markers for urine haptoglobin is associated with decline in renal function in type 2 diabetes in East Asians.

Gurung RL, Dorajoo R et al.

Sci Rep

Urinary haptoglobin levels in type 2 diabetes

2018-03-23

Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.

Teumer A, Tin A et al.

Diabetes

Urinary albumin-to-creatinine ratio in diabetes

2015-12-02

Genetic loci associated with renal function measures and chronic kidney disease in children: the Pediatric Investigation for Genetic Factors Linked with Renal Progression Consortium.

Wuttke M, Wong CS et al.

Nephrol Dial Transplant

Proteinuria in chronic kidney disease

2015-09-28

Novel genetic susceptibility loci for diabetic end-stage renal disease identified through robust naive Bayes classification.

Sambo F, Malovini A et al.

Diabetologia

End-stage renal disease or diabetic nephropathy in type 1 diabetes

2014-05-29

Chromosome 2q31.1 associates with ESRD in women with type 1 diabetes.

Sandholm N, McKnight AJ et al.

J Am Soc Nephrol

End-stage renal disease in Type 1 diabetics

2013-09-12

New susceptibility loci associated with kidney disease in type 1 diabetes.

Sandholm N, Salem RM et al.

PLoS Genet

Type 1 diabetes nephropathy

2012-09-20

Health & Traits Publications

Nidogen-1 could play a role in diabetic kidney disease development in type 2 diabetes: a genome-wide association meta-analysis.

Diverse ancestry whole-genome sequencing association study identifies <i>TBX5</i> and <i>PTK7</i> as susceptibility genes for posterior urethral valves.

Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease.

Variants in BANK1 are associated with lupus nephritis of European ancestry.

A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria.

Genome-wide association studies suggest that APOL1-environment interactions more likely trigger kidney disease in African Americans with nondiabetic nephropathy than strong APOL1-second gene interactions.

Genetic markers for urine haptoglobin is associated with decline in renal function in type 2 diabetes in East Asians.

Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.

Genetic loci associated with renal function measures and chronic kidney disease in children: the Pediatric Investigation for Genetic Factors Linked with Renal Progression Consortium.

Novel genetic susceptibility loci for diabetic end-stage renal disease identified through robust naive Bayes classification.

Chromosome 2q31.1 associates with ESRD in women with type 1 diabetes.

New susceptibility loci associated with kidney disease in type 1 diabetes.