Active: Gastroesophageal reflux disease Clear all

GWAS 2022-07-18

A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer's disease and gastrointestinal tract disorders.

Adewuyi EO, O'Brien EK et al.

Commun Biol

Consistent with the concept of the gut-brain phenomenon, observational studies suggest a relationshi...

Alzheimer's disease or gastroesophageal reflux disease

787859

Participants

N/A

Studies

Details PubMed

GWAS 2021-06-29

Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett's oesophagus and provides insights into clinical heterogeneity in reflux diagnosis.

Ong JS, An J et al.

Gut

Objective: Gastro-oesophageal reflux disease (GERD) has heterogeneous aetiology primarily attributab...

Gastroesophageal reflux disease

Replicated

2192831

Participants

N/A

Studies

Details PubMed

GWAS 2019-09-16

Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases.

An J, Gharahkhani P et al.

Nat Commun

Gastroesophageal reflux disease (GERD) is caused by gastric acid entering the esophagus. GERD has hi...

Barrett's esophagus or Esophageal adenocarcinoma

32925

Participants

N/A

Studies

Details PubMed

GWAS 2018-03-15

Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett's Esophagus.

Dong J, Levine DM et al.

Clin Gastroenterol Hepatol

Background & aims: Genome-wide association studies (GWAS) have identified more than 20 susceptib...

Esophageal adenocarcinoma x BMI interaction

4466

Participants

N/A

Studies

Details PubMed

GWAS 2016-08-03

A meta-analysis of reflux genome-wide association studies in 6750 Northern Europeans from the general population.

Bonfiglio F, Hysi PG et al.

Neurogastroenterol Motil

Gastroesophageal reflux disease (GERD), the regurgitation of gastric acids often accompanied by hear...

Gastroesophageal reflux disease

6750

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer's disease and gastrointestinal tract disorders.

Adewuyi EO, O'Brien EK et al.

Commun Biol

Alzheimer's disease or gastroesophageal reflux disease

2022-07-18

Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett's oesophagus and provides insights into clinical heterogeneity in reflux diagnosis.

Ong JS, An J et al.

Gut

Gastroesophageal reflux disease

2021-06-29

Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases.

An J, Gharahkhani P et al.

Nat Commun

Barrett's esophagus or Esophageal adenocarcinoma

2019-09-16

Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett's Esophagus.

Dong J, Levine DM et al.

Clin Gastroenterol Hepatol

Esophageal adenocarcinoma x BMI interaction

2018-03-15

A meta-analysis of reflux genome-wide association studies in 6750 Northern Europeans from the general population.

Bonfiglio F, Hysi PG et al.

Neurogastroenterol Motil

Gastroesophageal reflux disease

2016-08-03