Active: Hyperthyroidism Clear all

GWAS 2024-07-27

Uncovering the Shared Genetic Components of Thyroid Disorders and Reproductive Health.

Figuerêdo J, Krebs K et al.

Eur J Endocrinol

Objective: The aim of the study is to map the shared genetic component and relationships between thy...

Hyperthyroidism

743008

Participants

N/A

Studies

Details PubMed

GWAS 2023-10-23

Genome-wide association study of thyroid-stimulating hormone highlights new genes, pathways and associations with thyroid disease.

Williams AT, Chen J et al.

Nat Commun

Thyroid hormones play a critical role in regulation of multiple physiological functions and thyroid ...

Thyroid stimulating hormone levels

Replicated

343604

Participants

N/A

Studies

Details PubMed

GWAS 2021-09-14

Association of Polygenetic Risk Scores Related to Immunity and Inflammation with Hyperthyroidism Risk and Interactions between the Polygenetic Scores and Dietary Factors in a Large Cohort.

Song MY, Park S

J Thyroid Res

Graves's disease and thyroiditis induce hyperthyroidism, the causes of which remain unclear, althoug...

Hyperthyroidism

39641

Participants

N/A

Studies

Details PubMed

GWAS 2020-12-01

Genome-wide meta-analysis reveals novel susceptibility loci for thyrotoxic periodic paralysis.

Hoi-Yee Li G, Cheung CL et al.

Eur J Endocrinol

Objective: Thyrotoxic periodic paralysis (TPP) is a rare and potentially fatal complication of hyper...

Thyrotoxic periodic paralysis

3835

Participants

N/A

Studies

Details PubMed

GWAS 2019-05-03

Assessment of Molecular Subtypes in Thyrotoxic Periodic Paralysis and Graves Disease Among Chinese Han Adults: A Population-Based Genome-Wide Association Study.

Zhao SX, Liu W et al.

JAMA Netw Open

Importance: Thyrotoxic periodic paralysis (TPP) is a potentially lethal complication of hyperthyroid...

Thyrotoxic hypokalemic periodic paralysis in Graves disease

Replicated

1575

Participants

N/A

Studies

Details PubMed

GWAS 2015-07-07

Genetic determinants of antithyroid drug-induced agranulocytosis by human leukocyte antigen genotyping and genome-wide association study.

Chen PL, Shih SR et al.

Nat Commun

Graves' disease is the leading cause of hyperthyroidism affecting 1.0-1.6% of the population. Antith...

Thionamide-induced agranulocytosis in Graves' disease

Replicated

1250

Participants

N/A

Studies

Details PubMed

GWAS 2014-05-22

Genome-wide association study identifies a novel susceptibility gene for serum TSH levels in Chinese populations.

Zhan M, Chen G et al.

Hum Mol Genet

Thyroid-stimulating hormone (TSH) is a sensitive indicator of thyroid function. High and low TSH lev...

Serum thyroid-stimulating hormone levels

Replicated

4581

Participants

N/A

Studies

Details PubMed

GWAS 2014-02-27

Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease.

Medici M, Porcu E et al.

PLoS Genet

Autoimmune thyroid diseases (AITD) are common, affecting 2-5% of the general population. Individuals...

Thyroid peroxidase antibody positivity

Replicated

27287

Participants

N/A

Studies

Details PubMed

GWAS 2013-04-29

Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis.

Zhao SX, Xue LQ et al.

Hum Mol Genet

Graves' disease (GD), characterized by autoantibodies targeting antigens specifically expressed in t...

Graves' disease

Replicated

19152

Participants

N/A

Studies

Details PubMed

GWAS 2013-02-07

A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.

Porcu E, Medici M et al.

PLoS Genet

Thyroid hormone is essential for normal metabolism and development, and overt abnormalities in thyro...

Thyroid hormone levels

26420

Participants

N/A

Studies

Details PubMed

GWAS 2011-08-14

A genome-wide association study identifies two new risk loci for Graves' disease.

Chu X, Pan CM et al.

Nat Genet

Graves' disease is a common autoimmune disorder characterized by thyroid stimulating hormone recepto...

Graves' disease

Replicated

10462

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Uncovering the Shared Genetic Components of Thyroid Disorders and Reproductive Health.

Figuerêdo J, Krebs K et al.

Eur J Endocrinol

Hyperthyroidism

2024-07-27

Genome-wide association study of thyroid-stimulating hormone highlights new genes, pathways and associations with thyroid disease.

Williams AT, Chen J et al.

Nat Commun

Thyroid stimulating hormone levels

2023-10-23

Association of Polygenetic Risk Scores Related to Immunity and Inflammation with Hyperthyroidism Risk and Interactions between the Polygenetic Scores and Dietary Factors in a Large Cohort.

Song MY, Park S

J Thyroid Res

Hyperthyroidism

2021-09-14

Genome-wide meta-analysis reveals novel susceptibility loci for thyrotoxic periodic paralysis.

Hoi-Yee Li G, Cheung CL et al.

Eur J Endocrinol

Thyrotoxic periodic paralysis

2020-12-01

Assessment of Molecular Subtypes in Thyrotoxic Periodic Paralysis and Graves Disease Among Chinese Han Adults: A Population-Based Genome-Wide Association Study.

Zhao SX, Liu W et al.

JAMA Netw Open

Thyrotoxic hypokalemic periodic paralysis in Graves disease

2019-05-03

Genetic determinants of antithyroid drug-induced agranulocytosis by human leukocyte antigen genotyping and genome-wide association study.

Chen PL, Shih SR et al.

Nat Commun

Thionamide-induced agranulocytosis in Graves' disease

2015-07-07

Genome-wide association study identifies a novel susceptibility gene for serum TSH levels in Chinese populations.

Zhan M, Chen G et al.

Hum Mol Genet

Serum thyroid-stimulating hormone levels

2014-05-22

Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease.

Medici M, Porcu E et al.

PLoS Genet

Thyroid peroxidase antibody positivity

2014-02-27

Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis.

Zhao SX, Xue LQ et al.

Hum Mol Genet

Graves' disease

2013-04-29

A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.

Porcu E, Medici M et al.

PLoS Genet

Thyroid hormone levels

2013-02-07

A genome-wide association study identifies two new risk loci for Graves' disease.

Chu X, Pan CM et al.

Nat Genet

Graves' disease

2011-08-14