Active: Hypothyroidism Clear all

GWAS 2025-11-14

Genome-wide association study and polygenic risk prediction of hypothyroidism.

Rand SA, Ahlberg G et al.

Nat Genet

We performed a genome-wide meta-analysis of hypothyroidism (113,393 cases and 1,065,268 controls), f...

Thyroid stimulating hormone levels

Replicated

482873

Participants

N/A

Studies

Details PubMed

GWAS 2024-05-15

Oral and non-oral lichen planus show genetic heterogeneity and differential risk for autoimmune disease and oral cancer.

Reeve MP, Vehviläinen M et al.

Am J Hum Genet

Lichen planus (LP) is a T-cell-mediated inflammatory disease affecting squamous epithelia in many pa...

ICD10 L43: Lichen planus

412090

Participants

N/A

Studies

Details PubMed

GWAS 2024-02-17

Shared genetic architecture between hypothyroidism and rheumatoid arthritis: A large-scale cross-trait analysis.

Liu R, Shang X et al.

Mol Immunol

In recent years, mounting evidence has indicated a co-morbid relationship between hypothyroidism and...

Hypothyroidism or rheumatoid arthritis (pleiotropy)

591750

Participants

N/A

Studies

Details PubMed

GWAS 2023-10-23

Genome-wide association study of thyroid-stimulating hormone highlights new genes, pathways and associations with thyroid disease.

Williams AT, Chen J et al.

Nat Commun

Thyroid hormones play a critical role in regulation of multiple physiological functions and thyroid ...

Thyroid stimulating hormone levels

Replicated

343604

Participants

N/A

Studies

Details PubMed

GWAS 2023-09-03

Interactions between Polygenetic Variants and Lifestyle Factors in Hypothyroidism: A Hospital-Based Cohort Study.

Kim DS, Park S

Nutrients

Hypothyroidism is a prevalent endocrine disorder and is associated with a variety of metabolic distu...

Hypothyroidism

56124

Participants

N/A

Studies

Details PubMed

GWAS 2023-01-18

Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation.

Saarentaus EC, Karjalainen J et al.

Nat Commun

Inflammatory and infectious upper respiratory diseases (ICD-10: J30-J39), such as diseases of the si...

Pharyngeal disease

Replicated

232365

Participants

N/A

Studies

Details PubMed

GWAS 2022-08-20

Genetic association and Mendelian randomization for hypothyroidism highlight immune molecular mechanisms.

Mathieu S, Briend M et al.

iScience

We carried out a genome-wide association analysis including 51,194 cases of hypothyroidism and 443,3...

Hypothyroidism

Replicated

689720

Participants

N/A

Studies

Details PubMed

GWAS 2022-05-10

GWAS of thyroid dysgenesis identifies a risk locus at 2q33.3 linked to regulation of Wnt signaling.

Narumi S, Opitz R et al.

Hum Mol Genet

Congenital hypothyroidism due to thyroid dysgenesis (TD), presented as thyroid aplasia, hypoplasia o...

Thyroid dysgenesis

Replicated

12941

Participants

N/A

Studies

Details PubMed

GWAS 2022-02-01

Identification of genetic risk loci and prioritization of genes and pathways for myasthenia gravis: a genome-wide association study.

Chia R, Saez-Atienzar S et al.

Proc Natl Acad Sci U S A

Myasthenia gravis is a chronic autoimmune disease characterized by autoantibody-mediated interferenc...

Myasthenia gravis

Replicated

45655

Participants

N/A

Studies

Details PubMed

GWAS 2020-11-26

Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health.

Strausz S, Ruotsalainen S et al.

Eur Respir J

There is currently limited understanding of the genetic aetiology of obstructive sleep apnoea (OSA)....

Obstructive sleep apnea

Replicated

1177519

Participants

N/A

Studies

Details PubMed

GWAS 2020-02-20

Genome-Wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length.

Li C, Stoma S et al.

Am J Hum Genet

Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform...

Leukocyte telomere length

78592

Participants

N/A

Studies

Details PubMed

GWAS 2020-02-04

AATF and SMARCA2 are associated with thyroid volume in Hashimoto's thyroiditis patients.

Brčić L, Barić A et al.

Sci Rep

Thyroid volume of Hashimoto's thyroiditis (HT) patients varies in size over the course of disease an...

Thyroid volume in Hashimoto’s thyroiditis

345

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genome-wide association study and polygenic risk prediction of hypothyroidism.

Rand SA, Ahlberg G et al.

Nat Genet

Thyroid stimulating hormone levels

2025-11-14

Oral and non-oral lichen planus show genetic heterogeneity and differential risk for autoimmune disease and oral cancer.

Reeve MP, Vehviläinen M et al.

Am J Hum Genet

ICD10 L43: Lichen planus

2024-05-15

Shared genetic architecture between hypothyroidism and rheumatoid arthritis: A large-scale cross-trait analysis.

Liu R, Shang X et al.

Mol Immunol

Hypothyroidism or rheumatoid arthritis (pleiotropy)

2024-02-17

Genome-wide association study of thyroid-stimulating hormone highlights new genes, pathways and associations with thyroid disease.

Williams AT, Chen J et al.

Nat Commun

Thyroid stimulating hormone levels

2023-10-23

Interactions between Polygenetic Variants and Lifestyle Factors in Hypothyroidism: A Hospital-Based Cohort Study.

Kim DS, Park S

Nutrients

Hypothyroidism

2023-09-03

Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation.

Saarentaus EC, Karjalainen J et al.

Nat Commun

Pharyngeal disease

2023-01-18

Genetic association and Mendelian randomization for hypothyroidism highlight immune molecular mechanisms.

Mathieu S, Briend M et al.

iScience

Hypothyroidism

2022-08-20

GWAS of thyroid dysgenesis identifies a risk locus at 2q33.3 linked to regulation of Wnt signaling.

Narumi S, Opitz R et al.

Hum Mol Genet

Thyroid dysgenesis

2022-05-10

Identification of genetic risk loci and prioritization of genes and pathways for myasthenia gravis: a genome-wide association study.

Chia R, Saez-Atienzar S et al.

Proc Natl Acad Sci U S A

Myasthenia gravis

2022-02-01

Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health.

Strausz S, Ruotsalainen S et al.

Eur Respir J

Obstructive sleep apnea

2020-11-26

Genome-Wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length.

Li C, Stoma S et al.

Am J Hum Genet

Leukocyte telomere length

2020-02-20

AATF and SMARCA2 are associated with thyroid volume in Hashimoto's thyroiditis patients.

Brčić L, Barić A et al.

Sci Rep

Thyroid volume in Hashimoto’s thyroiditis

2020-02-04