Active: Insulin levels Clear all

GWAS 2023-06-08

Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake.

Williamson A, Norris DM et al.

Nat Genet

Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states. Previ...

Insulin fold change during an oral glucose tolerance test (adjusted for BMI)

53287

Participants

N/A

Studies

Details PubMed

GWAS 2023-02-20

Cross-trait analyses identify shared genetics between migraine, headache, and glycemic traits, and a causal relationship with fasting proinsulin.

Islam MR, Nyholt DR

Hum Genet

The co-occurrence of migraine and glycemic traits has long been reported in observational epidemiolo...

Migraine or 2-hr glucose levels

937810

Participants

N/A

Studies

Details PubMed

GWAS 2022-10-21

Genome-Wide Association Analysis of Over 170,000 Individuals from the UK Biobank Identifies Seven Loci Associated with Dietary Approaches to Stop Hypertension (DASH) Diet.

Mompeo O, Freidin MB et al.

Nutrients

Diet is a modifiable risk factor for common chronic diseases and mental health disorders, and its ef...

Dietary Approaches to Stop Hypertension (DASH) diet

173701

Participants

N/A

Studies

Details PubMed

GWAS 2022-08-16

Genome-wide association study of fasting proinsulin, fasting insulin, 2-hour postprandial proinsulin, and 2-hour postprandial insulin in Chinese Han people.

Lin L, Quan H et al.

Endokrynol Pol

Introduction: Fasting proinsulin (FPI) and fasting insulin (FI) have been demonstrated to be associa...

Fasting proinsulin levels in prediabetes

451

Participants

N/A

Studies

Details PubMed

GWAS 2021-07-25

Identification of genetic variants for blood insulin level in sex-stratified Korean population and evaluation of the causal relationship between blood insulin level and polycystic ovary syndrome.

Lim WY, Lee H et al.

Genes Genomics

Blood insulin level is an important risk factor for numerous disorders. Individual blood insulin lev...

Insulin levels

4658

Participants

N/A

Studies

Details PubMed

GWAS 2020-04-01

Shared genetic architecture and casual relationship between leptin levels and type 2 diabetes: large-scale cross-trait meta-analysis and Mendelian randomization analysis.

Wang X, Jia J et al.

BMJ Open Diabetes Res Care

Objective: We aimed to estimate genetic correlation, identify shared loci and test causality between...

Circulating leptin levels or fasting insulin levels

254263

Participants

N/A

Studies

Details PubMed

GWAS 2017-11-02

Genetic determinants of circulating GIP and GLP-1 concentrations.

Almgren P, Lindqvist A et al.

JCI Insight

The secretion of insulin and glucagon from the pancreas and the incretin hormones glucagon-like pept...

Insulin levels in response to oral glucose tolerance test (fasting)

Replicated

8249

Participants

N/A

Studies

Details PubMed

GWAS 2012-12-23

Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion.

Huyghe JR, Jackson AU et al.

Nat Genet

Insulin secretion has a crucial role in glucose homeostasis, and failure to secrete sufficient insul...

Fasting blood proinsulin levels

8229

Participants

N/A

Studies

Details PubMed

GWAS 2012-03-29

Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension susceptibility genes in Han Chinese with a genome-wide gene-based association study.

Yang HC, Liang YJ et al.

PLoS One

Hypertension is a complex disorder with high prevalence rates all over the world. We conducted the f...

Hypertension

Replicated

6118

Participants

N/A

Studies

Details PubMed

GWAS 2011-08-26

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.

Strawbridge RJ, Dupuis J et al.

Diabetes

Objective: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin ...

Proinsulin levels

Replicated

27079

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake.

Williamson A, Norris DM et al.

Nat Genet

Insulin fold change during an oral glucose tolerance test (adjusted for BMI)

2023-06-08

Cross-trait analyses identify shared genetics between migraine, headache, and glycemic traits, and a causal relationship with fasting proinsulin.

Islam MR, Nyholt DR

Hum Genet

Migraine or 2-hr glucose levels

2023-02-20

Genome-Wide Association Analysis of Over 170,000 Individuals from the UK Biobank Identifies Seven Loci Associated with Dietary Approaches to Stop Hypertension (DASH) Diet.

Mompeo O, Freidin MB et al.

Nutrients

Dietary Approaches to Stop Hypertension (DASH) diet

2022-10-21

Genome-wide association study of fasting proinsulin, fasting insulin, 2-hour postprandial proinsulin, and 2-hour postprandial insulin in Chinese Han people.

Lin L, Quan H et al.

Endokrynol Pol

Fasting proinsulin levels in prediabetes

2022-08-16

Identification of genetic variants for blood insulin level in sex-stratified Korean population and evaluation of the causal relationship between blood insulin level and polycystic ovary syndrome.

Lim WY, Lee H et al.

Genes Genomics

Insulin levels

2021-07-25

Shared genetic architecture and casual relationship between leptin levels and type 2 diabetes: large-scale cross-trait meta-analysis and Mendelian randomization analysis.

Wang X, Jia J et al.

BMJ Open Diabetes Res Care

Circulating leptin levels or fasting insulin levels

2020-04-01

Genetic determinants of circulating GIP and GLP-1 concentrations.

Almgren P, Lindqvist A et al.

JCI Insight

Insulin levels in response to oral glucose tolerance test (fasting)

2017-11-02

Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion.

Huyghe JR, Jackson AU et al.

Nat Genet

Fasting blood proinsulin levels

2012-12-23

Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension susceptibility genes in Han Chinese with a genome-wide gene-based association study.

Yang HC, Liang YJ et al.

PLoS One

Hypertension

2012-03-29

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.

Strawbridge RJ, Dupuis J et al.

Diabetes

Proinsulin levels

2011-08-26