Active: LDL cholesterol Clear all

GWAS 2023-09-05

Demonstrating paths for unlocking the value of cloud genomics through cross cohort analysis.

Deflaux N, Selvaraj MS et al.

Nat Commun

Recently, large scale genomic projects such as All of Us and the UK Biobank have introduced a new re...

LDL cholesterol levels

228736

Participants

N/A

Studies

Details PubMed

GWAS 2023-06-30

A multivariate genome-wide association study of psycho-cardiometabolic multimorbidity.

Baltramonaityte V, Pingault JB et al.

PLoS Genet

Coronary artery disease (CAD), type 2 diabetes (T2D) and depression are among the leading causes of ...

Psycho-cardiometabolic multimorbidity (multivariate analysis)

562507

Participants

N/A

Studies

Details PubMed

GWAS 2022-09-08

Common and Rare <i>PCSK9</i> Variants Associated with Low-Density Lipoprotein Cholesterol Levels and the Risk of Diabetes Mellitus: A Mendelian Randomization Study.

Hsu LA, Teng MS et al.

Int J Mol Sci

PCSK9 is a candidate locus for low-density lipoprotein cholesterol (LDL-C) levels. The cause-effect ...

LDL cholesterol levels

75441

Participants

N/A

Studies

Details PubMed

GWAS 2022-06-14

Genome Wide Association Studies of Variant-by-Thiazide Interaction on Lipids Identifies a Novel Low-Density Lipoprotein Cholesterol Locus.

Downie CG, Highland HM et al.

Circ Res

No abstract available Keywords: cholesterol; cholesterol, LDL; diuretics; pharmacogenetics; thiazide...

LDL cholesterol x thiazide diuretic use interaction

394444

Participants

N/A

Studies

Details PubMed

GWAS 2022-02-25

Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.

Richardson TG, Leyden GM et al.

PLoS Biol

Large-scale molecular profiling and genotyping provide a unique opportunity to systematically compar...

Apolipoprotein A1 levels

115082

Participants

N/A

Studies

Details PubMed

GWAS 2021-12-03

Recessive Genome-wide Meta-analysis Illuminates Genetic Architecture of Type 2 Diabetes.

O'Connor MJ, Schroeder P et al.

Diabetes

Most genome-wide association studies (GWAS) of complex traits are performed using models with additi...

Type 2 diabetes

Replicated

419559

Participants

N/A

Studies

Details PubMed

GWAS 2021-10-05

Genetic Studies of Metabolomics Change After a Liquid Meal Illuminate Novel Pathways for Glucose and Lipid Metabolism.

Li-Gao R, Hughes DA et al.

Diabetes

Humans spend the greater part of the day in a postprandial state. However, the genetic basis of post...

Postprandial phosphatidylcholine and other cholines

4348

Participants

N/A

Studies

Details PubMed

GWAS 2020-06-03

Phenotypic and Genetic Characterization of Lower LDL-C and Increased Type-2 Diabetes Risk in the UK Biobank.

Klimentidis YC, Arora A et al.

Diabetes

Although hyperlipidemia is traditionally considered a risk factor for type 2 diabetes (T2D), evidenc...

Low density lipoprotein cholesterol levels

431167

Participants

N/A

Studies

Details PubMed

GWAS 2020-03-23

Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis.

Richardson TG, Sanderson E et al.

PLoS Med

Circulating lipoprotein lipids cause coronary heart disease (CHD). However, the precise way in which...

LDL cholesterol levels

440546

Participants

N/A

Studies

Details PubMed

GWAS 2020-01-16

The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change.

Oni-Orisan A, Haldar T et al.

NPJ Genom Med

In pharmacogenomic studies of quantitative change, any association between genetic variants and the ...

Response to statins (LDL cholesterol percent change)(baseline-unadjusted)

1205

Participants

N/A

Studies

Details PubMed

GWAS 2019-12-06

Genome-wide meta-analysis of variant-by-diuretic interactions as modulators of lipid traits in persons of European and African ancestry.

de las Fuentes L, Sung YJ et al.

Pharmacogenomics J

Hypertension (HTN) is a significant risk factor for cardiovascular morbidity and mortality. Metaboli...

LDL cholesterol levels x loop diuretics use interaction

38834

Participants

N/A

Studies

Details PubMed

GWAS 2019-11-12

Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration.

Noordam R, Bos MM et al.

Nat Commun

Both short and long sleep are associated with an adverse lipid profile, likely through different bio...

LDL cholesterol levels x short total sleep time interaction (2df test)

Replicated

111660

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Demonstrating paths for unlocking the value of cloud genomics through cross cohort analysis.

Deflaux N, Selvaraj MS et al.

Nat Commun

LDL cholesterol levels

2023-09-05

A multivariate genome-wide association study of psycho-cardiometabolic multimorbidity.

Baltramonaityte V, Pingault JB et al.

PLoS Genet

Psycho-cardiometabolic multimorbidity (multivariate analysis)

2023-06-30

Common and Rare <i>PCSK9</i> Variants Associated with Low-Density Lipoprotein Cholesterol Levels and the Risk of Diabetes Mellitus: A Mendelian Randomization Study.

Hsu LA, Teng MS et al.

Int J Mol Sci

LDL cholesterol levels

2022-09-08

Genome Wide Association Studies of Variant-by-Thiazide Interaction on Lipids Identifies a Novel Low-Density Lipoprotein Cholesterol Locus.

Downie CG, Highland HM et al.

Circ Res

LDL cholesterol x thiazide diuretic use interaction

2022-06-14

Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.

Richardson TG, Leyden GM et al.

PLoS Biol

Apolipoprotein A1 levels

2022-02-25

Recessive Genome-wide Meta-analysis Illuminates Genetic Architecture of Type 2 Diabetes.

O'Connor MJ, Schroeder P et al.

Diabetes

Type 2 diabetes

2021-12-03

Genetic Studies of Metabolomics Change After a Liquid Meal Illuminate Novel Pathways for Glucose and Lipid Metabolism.

Li-Gao R, Hughes DA et al.

Diabetes

Postprandial phosphatidylcholine and other cholines

2021-10-05

Phenotypic and Genetic Characterization of Lower LDL-C and Increased Type-2 Diabetes Risk in the UK Biobank.

Klimentidis YC, Arora A et al.

Diabetes

Low density lipoprotein cholesterol levels

2020-06-03

Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis.

Richardson TG, Sanderson E et al.

PLoS Med

LDL cholesterol levels

2020-03-23

The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change.

Oni-Orisan A, Haldar T et al.

NPJ Genom Med

Response to statins (LDL cholesterol percent change)(baseline-unadjusted)

2020-01-16

Genome-wide meta-analysis of variant-by-diuretic interactions as modulators of lipid traits in persons of European and African ancestry.

de las Fuentes L, Sung YJ et al.

Pharmacogenomics J

LDL cholesterol levels x loop diuretics use interaction

2019-12-06

Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration.

Noordam R, Bos MM et al.

Nat Commun

LDL cholesterol levels x short total sleep time interaction (2df test)

2019-11-12