Active: Narcolepsy Clear all

GWAS 2023-05-15

Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy.

Ollila HM, Sharon E et al.

Nat Commun

Narcolepsy type 1 (NT1) is caused by a loss of hypocretin/orexin transmission. Risk factors include ...

Type 1 narcolepsy

90929

Participants

N/A

Studies

Details PubMed

GWAS 2020-05-01

Constructing gene network for type 1 narcolepsy based on genome-wide association study and differential gene expression analysis (STROBE).

Ouyang H, Wang S et al.

Medicine (Baltimore)

Although many genes that affect narcolepsy risk have been identified, the interactions among these g...

Narcolepsy with cataplexy

2885

Participants

N/A

Studies

Details PubMed

GWAS 2019-01-30

Pandemrix-induced narcolepsy is associated with genes related to immunity and neuronal survival.

Hallberg P, Smedje H et al.

EBioMedicine

The incidence of narcolepsy rose sharply after the swine influenza A (H1N1) vaccination campaign wit...

Pandemrix-induced narcolepsy

Replicated

12090

Participants

N/A

Studies

Details PubMed

GWAS 2018-09-28

A variant at 9q34.11 is associated with HLA-DQB1*06:02 negative essential hypersomnia.

Miyagawa T, Khor SS et al.

J Hum Genet

Essential hypersomnia (EHS) is a lifelong disorder characterized by excessive daytime sleepiness wit...

Hypersomnia (HLA-DQB1*06:02 negative)

Replicated

2417

Participants

N/A

Studies

Details PubMed

GWAS 2015-09-03

Using the Coriell Personalized Medicine Collaborative Data to conduct a genome-wide association study of sleep duration.

Scheinfeldt LB, Gharani N et al.

Am J Med Genet B Neuropsychiatr Genet

Sleep is critical to health and functionality, and several studies have investigated the inherited c...

Sleep duration

Replicated

3954

Participants

N/A

Studies

Details PubMed

GWAS 2015-05-15

A polymorphism in CCR1/CCR3 is associated with narcolepsy.

Toyoda H, Miyagawa T et al.

Brain Behav Immun

Etiology of narcolepsy-cataplexy involves multiple genetic and environmental factors. While the huma...

Narcolepsy with cataplexy

Replicated

3080

Participants

N/A

Studies

Details PubMed

GWAS 2013-10-31

Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.

Han F, Faraco J et al.

PLoS Genet

Previous studies in narcolepsy, an autoimmune disorder affecting hypocretin (orexin) neurons and rec...

Narcolepsy

Replicated

17374

Participants

N/A

Studies

Details PubMed

GWAS 2013-04-16

Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia.

Khor SS, Miyagawa T et al.

PeerJ

Essential hypersomnia (EHS), a sleep disorder characterized by excessive daytime sleepiness, can be ...

Hypersomnia (HLA-DQB1*06:02 negative)

687

Participants

N/A

Studies

Details PubMed

GWAS 2013-03-18

Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study.

Luca G, Haba-Rubio J et al.

J Sleep Res

The aim of this study was to describe the clinical and PSG characteristics of narcolepsy with catapl...

Narcolepsy with cataplexy

Replicated

972

Participants

N/A

Studies

Details PubMed

GWAS 2013-01-01

ImmunoChip study implicates antigen presentation to T cells in narcolepsy.

Faraco J, Lin L et al.

PLoS Genet

Recent advances in the identification of susceptibility genes and environmental exposures provide br...

Narcolepsy

12307

Participants

N/A

Studies

Details PubMed

GWAS 2010-08-15

Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy.

Hor H, Kutalik Z et al.

Nat Genet

Narcolepsy is a rare sleep disorder with the strongest human leukocyte antigen (HLA) association eve...

Narcolepsy

Replicated

2129

Participants

N/A

Studies

Details PubMed

GWAS 2009-05-03

Narcolepsy is strongly associated with the T-cell receptor alpha locus.

Hallmayer J, Faraco J et al.

Nat Genet

Narcolepsy with cataplexy, characterized by sleepiness and rapid onset into REM sleep, affects 1 in ...

Narcolepsy

Replicated

4042

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy.

Ollila HM, Sharon E et al.

Nat Commun

Type 1 narcolepsy

2023-05-15

Constructing gene network for type 1 narcolepsy based on genome-wide association study and differential gene expression analysis (STROBE).

Ouyang H, Wang S et al.

Medicine (Baltimore)

Narcolepsy with cataplexy

2020-05-01

Pandemrix-induced narcolepsy is associated with genes related to immunity and neuronal survival.

Hallberg P, Smedje H et al.

EBioMedicine

Pandemrix-induced narcolepsy

2019-01-30

A variant at 9q34.11 is associated with HLA-DQB1*06:02 negative essential hypersomnia.

Miyagawa T, Khor SS et al.

J Hum Genet

Hypersomnia (HLA-DQB1*06:02 negative)

2018-09-28

Using the Coriell Personalized Medicine Collaborative Data to conduct a genome-wide association study of sleep duration.

Scheinfeldt LB, Gharani N et al.

Am J Med Genet B Neuropsychiatr Genet

Sleep duration

2015-09-03

A polymorphism in CCR1/CCR3 is associated with narcolepsy.

Toyoda H, Miyagawa T et al.

Brain Behav Immun

Narcolepsy with cataplexy

2015-05-15

Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.

Han F, Faraco J et al.

PLoS Genet

Narcolepsy

2013-10-31

Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia.

Khor SS, Miyagawa T et al.

PeerJ

Hypersomnia (HLA-DQB1*06:02 negative)

2013-04-16

Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study.

Luca G, Haba-Rubio J et al.

J Sleep Res

Narcolepsy with cataplexy

2013-03-18

ImmunoChip study implicates antigen presentation to T cells in narcolepsy.

Faraco J, Lin L et al.

PLoS Genet

Narcolepsy

2013-01-01

Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy.

Hor H, Kutalik Z et al.

Nat Genet

Narcolepsy

2010-08-15

Narcolepsy is strongly associated with the T-cell receptor alpha locus.

Hallmayer J, Faraco J et al.

Nat Genet

Narcolepsy

2009-05-03