Active: Nonsyndromic cleft palate Clear all

GWAS 2024-11-06

High incidence and geographic distribution of cleft palate in Finland are associated with the IRF6 gene.

Rahimov F, Nieminen P et al.

Nat Commun

In Finland, the frequency of isolated cleft palate (CP) is higher than that of isolated cleft lip wi...

Nonsyndromic cleft palate

Replicated

708171

Participants

N/A

Studies

Details PubMed

GWAS 2024-04-18

Shared genetic risk between major orofacial cleft phenotypes in an African population.

Alade A, Peter T et al.

Genet Epidemiol

Nonsyndromic orofacial clefts (NSOFCs) represent a large proportion (70%-80%) of all OFCs. They can ...

Cleft lip with or without cleft palate or cleft palate (pleiotropy)

3178

Participants

N/A

Studies

Details PubMed

GWAS 2020-08-06

Genome-wide Analyses Identify a Novel Risk Locus for Nonsyndromic Cleft Palate.

He M, Zuo X et al.

J Dent Res

The 3 major subphenotypes observed in patients with nonsyndromic orofacial clefts (NSOFCs) are nonsy...

Nonsyndromic cleft palate

Replicated

11404

Participants

N/A

Studies

Details PubMed

GWAS 2017-01-13

Imputation of orofacial clefting data identifies novel risk loci and sheds light on the genetic background of cleft lip ± cleft palate and cleft palate only.

Ludwig KU, Böhmer AC et al.

Hum Mol Genet

Nonsyndromic cleft lip with or without cleft palate (nsCL/P) is among the most common human birth de...

Nonsyndromic cleft lip with or without cleft palate

Replicated

8309

Participants

N/A

Studies

Details PubMed

GWAS 2014-02-06

Evidence of gene-environment interaction for two genes on chromosome 4 and environmental tobacco smoke in controlling the risk of nonsyndromic cleft palate.

Wu T, Schwender H et al.

PLoS One

Nonsyndromic cleft palate (CP) is one of the most common human birth defects and both genetic and en...

Cleft plate (environmental tobacco smoke interaction)

1650

Participants

N/A

Studies

Details PubMed

GWAS 2011-05-26

Evidence for gene-environment interaction in a genome wide study of nonsyndromic cleft palate.

Beaty TH, Ruczinski I et al.

Genet Epidemiol

Nonsyndromic cleft palate (CP) is a common birth defect with a complex and heterogeneous etiology in...

Orofacial clefts (maternal alcohol consumption interaction)

1650

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

High incidence and geographic distribution of cleft palate in Finland are associated with the IRF6 gene.

Rahimov F, Nieminen P et al.

Nat Commun

Nonsyndromic cleft palate

2024-11-06

Shared genetic risk between major orofacial cleft phenotypes in an African population.

Alade A, Peter T et al.

Genet Epidemiol

Cleft lip with or without cleft palate or cleft palate (pleiotropy)

2024-04-18

Genome-wide Analyses Identify a Novel Risk Locus for Nonsyndromic Cleft Palate.

He M, Zuo X et al.

J Dent Res

Nonsyndromic cleft palate

2020-08-06

Imputation of orofacial clefting data identifies novel risk loci and sheds light on the genetic background of cleft lip ± cleft palate and cleft palate only.

Ludwig KU, Böhmer AC et al.

Hum Mol Genet

Nonsyndromic cleft lip with or without cleft palate

2017-01-13

Evidence of gene-environment interaction for two genes on chromosome 4 and environmental tobacco smoke in controlling the risk of nonsyndromic cleft palate.

Wu T, Schwender H et al.

PLoS One

Cleft plate (environmental tobacco smoke interaction)

2014-02-06

Evidence for gene-environment interaction in a genome wide study of nonsyndromic cleft palate.

Beaty TH, Ruczinski I et al.

Genet Epidemiol

Orofacial clefts (maternal alcohol consumption interaction)

2011-05-26