Active: Pain Clear all

GWAS 2025-08-20

Multi-ancestry meta-analysis of keloids uncovers novel susceptibility loci in diverse populations.

Greene CA, Hampton G et al.

Nat Commun

Keloids are raised scars that grow beyond original wound boundaries, resulting in pain and disfigure...

Keloid

Replicated

1600846

Participants

N/A

Studies

Details PubMed

GWAS 2025-05-16

A Spanish-Portuguese GWAS of progressive supranuclear palsy reveals a novel risk locus in NFASC.

García-González P, Rodrigo Lara H et al.

Eur J Hum Genet

Progressive supranuclear palsy (PSP) is a rare 4-repeat tauopathy that causes behavioural, movement ...

Progressive supranuclear palsy

3909

Participants

N/A

Studies

Details PubMed

GWAS 2025-04-11

The genetic architecture of and evolutionary constraints on the human pelvic form.

Xu L, Kun E et al.

Science

Human pelvic evolution following the human-chimpanzee divergence is thought to result in an obstetri...

Acetabular diameter

31115

Participants

N/A

Studies

Details PubMed

GWAS 2025-02-20

Genetic architectures of childhood maltreatment and causal influence of childhood maltreatment on health outcomes in adulthood.

Chen TT, Chen CY et al.

Mol Psychiatry

Childhood maltreatment is increasingly recognized as a pivotal risk factor for adverse health outcom...

Physical neglect

129017

Participants

N/A

Studies

Details PubMed

GWAS 2025-01-28

Associations between common genetic variants and income provide insights about the socio-economic health gradient.

Kweon H, Burik CAP et al.

Nat Hum Behav

We conducted a genome-wide association study on income among individuals of European descent (N = 66...

Individual income

72601

Participants

N/A

Studies

Details PubMed

GWAS 2025-01-01

A genome-wide association study of European advanced cancer patients treated with opioids identifies regulatory variants on chromosome 20 associated with pain intensity.

Minnai F, Shkodra M et al.

Eur J Pain

Opioids in step III of the WHO analgesic ladder are the standard of care for treating cancer pain. H...

Pain intensity in opioid-treated advanced cancer

2057

Participants

N/A

Studies

Details PubMed

GWAS 2024-11-23

Shared genetic architecture and causality between autism spectrum disorder and irritable bowel syndrome, multisite pain, and fatigue.

Li Y, Xie T et al.

Transl Psychiatry

Autism spectrum disorder (ASD) often co-occurs with functional somatic syndromes (FSS), such as irri...

Autism spectrum disorder (MTAG)

46350

Participants

N/A

Studies

Details PubMed

GWAS 2024-07-15

Genome-wide association reveals a locus in neuregulin 3 associated with gabapentin efficacy in women with chronic pelvic pain.

Mackenzie SC, Rahmioglu N et al.

iScience

Chronic pelvic pain (CPP) in women with no obvious pelvic pathology has few evidence-based treatment...

Response to gabapentin in female chronic pelvic pain

Participants

N/A

Studies

Details PubMed

GWAS 2024-05-28

A genome-wide meta-analysis of palmoplantar pustulosis implicates Th2 responses and cigarette smoking in disease pathogenesis.

Hernandez-Cordero A, Thomas L et al.

J Allergy Clin Immunol

Palmoplantar pustulosis (PPP) is an inflammatory skin disorder that mostly affects smokers and manif...

Palmoplantar pustulosis

403506

Participants

N/A

Studies

Details PubMed

GWAS 2024-04-17

Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes.

Toikumo S, Jennings MV et al.

Nat Hum Behav

Tobacco use disorder (TUD) is the most prevalent substance use disorder in the world. Genetic factor...

Tobacco use disorder

898680

Participants

N/A

Studies

Details PubMed

GWAS 2024-03-01

A multi-ancestry genetic study of pain intensity in 598,339 veterans.

Toikumo S, Vickers-Smith R et al.

Nat Med

Chronic pain is a common problem, with more than one-fifth of adult Americans reporting pain daily o...

Pain intensity (without opioid use disorder)

416740

Participants

N/A

Studies

Details PubMed

GWAS 2023-10-16

Genome wide association joint analysis reveals 99 risk loci for pain susceptibility and pleiotropic relationships with psychiatric, metabolic, and immunological traits.

Mocci E, Ward K et al.

PLoS Genet

Chronic pain is at epidemic proportions in the United States, represents a significant burden on our...

Pain (pleiotropy)

361194

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Multi-ancestry meta-analysis of keloids uncovers novel susceptibility loci in diverse populations.

Greene CA, Hampton G et al.

Nat Commun

Keloid

2025-08-20

A Spanish-Portuguese GWAS of progressive supranuclear palsy reveals a novel risk locus in NFASC.

García-González P, Rodrigo Lara H et al.

Eur J Hum Genet

Progressive supranuclear palsy

2025-05-16

The genetic architecture of and evolutionary constraints on the human pelvic form.

Xu L, Kun E et al.

Science

Acetabular diameter

2025-04-11

Genetic architectures of childhood maltreatment and causal influence of childhood maltreatment on health outcomes in adulthood.

Chen TT, Chen CY et al.

Mol Psychiatry

Physical neglect

2025-02-20

Associations between common genetic variants and income provide insights about the socio-economic health gradient.

Kweon H, Burik CAP et al.

Nat Hum Behav

Individual income

2025-01-28

A genome-wide association study of European advanced cancer patients treated with opioids identifies regulatory variants on chromosome 20 associated with pain intensity.

Minnai F, Shkodra M et al.

Eur J Pain

Pain intensity in opioid-treated advanced cancer

2025-01-01

Shared genetic architecture and causality between autism spectrum disorder and irritable bowel syndrome, multisite pain, and fatigue.

Li Y, Xie T et al.

Transl Psychiatry

Autism spectrum disorder (MTAG)

2024-11-23

Genome-wide association reveals a locus in neuregulin 3 associated with gabapentin efficacy in women with chronic pelvic pain.

Mackenzie SC, Rahmioglu N et al.

iScience

Response to gabapentin in female chronic pelvic pain

2024-07-15

A genome-wide meta-analysis of palmoplantar pustulosis implicates Th2 responses and cigarette smoking in disease pathogenesis.

Hernandez-Cordero A, Thomas L et al.

J Allergy Clin Immunol

Palmoplantar pustulosis

2024-05-28

Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes.

Toikumo S, Jennings MV et al.

Nat Hum Behav

Tobacco use disorder

2024-04-17

A multi-ancestry genetic study of pain intensity in 598,339 veterans.

Toikumo S, Vickers-Smith R et al.

Nat Med

Pain intensity (without opioid use disorder)

2024-03-01

Genome wide association joint analysis reveals 99 risk loci for pain susceptibility and pleiotropic relationships with psychiatric, metabolic, and immunological traits.

Mocci E, Ward K et al.

PLoS Genet

Pain (pleiotropy)

2023-10-16