Active: Primary open angle glaucoma Clear all

GWAS 2024-01-01

A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma.

Verma SS, Gudiseva HV et al.

Cell

Primary open-angle glaucoma (POAG), the leading cause of irreversible blindness worldwide, dispropor...

Primary open angle glaucoma

Replicated

54779

Participants

N/A

Studies

Details PubMed

GWAS 2023-06-29

Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci.

Han X, Gharahkhani P et al.

Nat Genet

Glaucoma, a leading cause of irreversible blindness, is a highly heritable human disease. Previous g...

Primary open angle glaucoma (MTAG)

379422

Participants

N/A

Studies

Details PubMed

GWAS 2018-10-13

Genome-wide association study of primary open-angle glaucoma in continental and admixed African populations.

Bonnemaijer PWM, Iglesias AI et al.

Hum Genet

Primary open angle glaucoma (POAG) is a complex disease with a major genetic contribution. Its preva...

Glaucoma (primary open-angle)

Replicated

12070

Participants

N/A

Studies

Details PubMed

GWAS 2016-11-15

Genome-wide association study identifies WNT7B as a novel locus for central corneal thickness in Latinos.

Gao X, Nannini DR et al.

Hum Mol Genet

The cornea is the outermost layer of the eye and is a vital component of focusing incoming light on ...

Central corneal thickness

Replicated

4515

Participants

N/A

Studies

Details PubMed

GWAS 2016-09-13

Epistatic Gene-Based Interaction Analyses for Glaucoma in eMERGE and NEIGHBOR Consortium.

Verma SS, Cooke Bailey JN et al.

PLoS Genet

Primary open angle glaucoma (POAG) is a complex disease and is one of the major leading causes of bl...

Glaucoma (primary open-angle)

5090

Participants

N/A

Studies

Details PubMed

GWAS 2016-03-22

Genetic association and stress mediated down-regulation in trabecular meshwork implicates MPP7 as a novel candidate gene in primary open angle glaucoma.

Vishal M, Sharma A et al.

BMC Med Genomics

Glaucoma is the largest cause of irreversible blindness affecting more than 60 million people global...

Glaucoma (primary open-angle)

Replicated

1317

Participants

N/A

Studies

Details PubMed

GWAS 2015-04-10

A common variant near TGFBR3 is associated with primary open angle glaucoma.

Li Z, Allingham RR et al.

Hum Mol Genet

Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with ...

Glaucoma (primary open-angle)

Replicated

49203

Participants

N/A

Studies

Details PubMed

GWAS 2013-03-11

A genome-wide association study for primary open angle glaucoma and macular degeneration reveals novel Loci.

Scheetz TE, Fingert JH et al.

PLoS One

Glaucoma and age-related macular degeneration (AMD) are the two leading causes of visual loss in the...

Age-related macular degeneration

Replicated

797

Participants

N/A

Studies

Details PubMed

GWAS 2012-04-28

Genome-wide association study of primary open angle glaucoma risk and quantitative traits.

Gibson J, Griffiths H et al.

Mol Vis

Purpose: Primary open angle glaucoma (POAG) is a characteristic optic neuropathy which progresses to...

Glaucoma (primary open-angle)

Replicated

6111

Participants

N/A

Studies

Details PubMed

GWAS 2012-04-26

Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma.

Wiggs JL, Yaspan BL et al.

PLoS Genet

Optic nerve degeneration caused by glaucoma is a leading cause of blindness worldwide. Patients affe...

Glaucoma (primary open-angle)

6633

Participants

N/A

Studies

Details PubMed

GWAS 2012-03-22

A genome-wide association study in the Japanese population confirms 9p21 and 14q23 as susceptibility loci for primary open angle glaucoma.

Osman W, Low SK et al.

Hum Mol Genet

Primary open angle glaucoma (POAG) is one of leading causes of adult blindness worldwide. To identif...

Glaucoma (primary open-angle)

Replicated

17007

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma.

Verma SS, Gudiseva HV et al.

Cell

Primary open angle glaucoma

2024-01-01

Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci.

Han X, Gharahkhani P et al.

Nat Genet

Primary open angle glaucoma (MTAG)

2023-06-29

Genome-wide association study of primary open-angle glaucoma in continental and admixed African populations.

Bonnemaijer PWM, Iglesias AI et al.

Hum Genet

Glaucoma (primary open-angle)

2018-10-13

Genome-wide association study identifies WNT7B as a novel locus for central corneal thickness in Latinos.

Gao X, Nannini DR et al.

Hum Mol Genet

Central corneal thickness

2016-11-15

Epistatic Gene-Based Interaction Analyses for Glaucoma in eMERGE and NEIGHBOR Consortium.

Verma SS, Cooke Bailey JN et al.

PLoS Genet

Glaucoma (primary open-angle)

2016-09-13

Genetic association and stress mediated down-regulation in trabecular meshwork implicates MPP7 as a novel candidate gene in primary open angle glaucoma.

Vishal M, Sharma A et al.

BMC Med Genomics

Glaucoma (primary open-angle)

2016-03-22

A common variant near TGFBR3 is associated with primary open angle glaucoma.

Li Z, Allingham RR et al.

Hum Mol Genet

Glaucoma (primary open-angle)

2015-04-10

A genome-wide association study for primary open angle glaucoma and macular degeneration reveals novel Loci.

Scheetz TE, Fingert JH et al.

PLoS One

Age-related macular degeneration

2013-03-11

Genome-wide association study of primary open angle glaucoma risk and quantitative traits.

Gibson J, Griffiths H et al.

Mol Vis

Glaucoma (primary open-angle)

2012-04-28

Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma.

Wiggs JL, Yaspan BL et al.

PLoS Genet

Glaucoma (primary open-angle)

2012-04-26

A genome-wide association study in the Japanese population confirms 9p21 and 14q23 as susceptibility loci for primary open angle glaucoma.

Osman W, Low SK et al.

Hum Mol Genet

Glaucoma (primary open-angle)

2012-03-22