Active: Progranulin levels Clear all

GWAS 2020-10-21

The FAM171A2 gene is a key regulator of progranulin expression and modifies the risk of multiple neurodegenerative diseases.

Xu W, Han SD et al.

Sci Adv

Progranulin (PGRN) is a secreted pleiotropic glycoprotein associated with the development of common ...

Cerebrospinal fluid progranulin levels

Replicated

1362

Participants

N/A

Studies

Details PubMed

GWAS 2017-11-27

Genome-wide meta-analysis identifies novel determinants of circulating serum progranulin.

Tönjes A, Scholz M et al.

Hum Mol Genet

Progranulin is a secreted protein with important functions in processes including immune and inflamm...

Progranulin levels

Replicated

4611

Participants

N/A

Studies

Details PubMed

GWAS 2010-12-10

Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma.

Carrasquillo MM, Nicholson AM et al.

Am J Hum Genet

Recent studies suggest progranulin (GRN) is a neurotrophic factor. Loss-of-function mutations in the...

Progranulin levels

Replicated

977

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

The FAM171A2 gene is a key regulator of progranulin expression and modifies the risk of multiple neurodegenerative diseases.

Xu W, Han SD et al.

Sci Adv

Cerebrospinal fluid progranulin levels

2020-10-21

Genome-wide meta-analysis identifies novel determinants of circulating serum progranulin.

Tönjes A, Scholz M et al.

Hum Mol Genet

Progranulin levels

2017-11-27

Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma.

Carrasquillo MM, Nicholson AM et al.

Am J Hum Genet

Progranulin levels

2010-12-10