Active: Prostate cancer Clear all

GWAS 2025-08-29

Efficient candidate drug target discovery through proteogenomics in a Scottish cohort.

Kuliesius J, Timmers PRHJ et al.

Commun Biol

Understanding the genomic basis of human proteomic variability provides powerful tools to probe pote...

E3 ubiquitin-protein ligase pellino homolog 1 protein levels (SomaScan ID:10758-2)

194

Participants

N/A

Studies

Details PubMed

GWAS 2025-02-10

Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups.

Hoffmann TJ, Graff RE et al.

Nat Genet

We conducted a multiancestry genome-wide association study of prostate-specific antigen (PSA) levels...

Prostate-specific antigen levels

392522

Participants

N/A

Studies

Details PubMed

GWAS 2024-10-02

Heterogeneous genetic architectures of prostate cancer susceptibility in sub-Saharan Africa.

Janivara R, Chen WC et al.

Nat Genet

Men of African descent have the highest prostate cancer incidence and mortality rates, yet the genet...

Prostate cancer

7472

Participants

N/A

Studies

Details PubMed

GWAS 2024-05-06

Unravelling genetic architecture of circulatory amino acid levels, and their effect on risk of complex disorders.

Abar L, Zuber V et al.

NAR Genom Bioinform

Variations in serum amino acid levels are linked to a multitude of complex disorders. We report the ...

Alanine levels

117944

Participants

N/A

Studies

Details PubMed

GWAS 2024-04-17

An early-onset specific polygenic risk score optimizes age-based risk estimate and stratification of prostate cancer: population-based cohort study.

Cheng Y, Wu L et al.

J Transl Med

Early-onset prostate cancer (EOPC, ≤ 55 years) has a unique clinical entity harboring high genetic r...

Prostate cancer

167517

Participants

N/A

Studies

Details PubMed

GWAS 2024-03-27

New role of fat-free mass in cancer risk linked with genetic predisposition.

Harris BHL, Di Giovannantonio M et al.

Sci Rep

Cancer risk is associated with the widely debated measure body mass index (BMI). Fat mass and fat-fr...

Postmenopausal breast cancer

175905

Participants

N/A

Studies

Details PubMed

GWAS 2024-02-23

Genetic susceptibility to prostate cancer in Taiwan: A genome-wide association study.

Bau DT, Tsai CW et al.

Mol Carcinog

We conducted the first genome-wide association study (GWAS) of prostate cancer (PCa) in Taiwan with ...

Prostate cancer

82553

Participants

N/A

Studies

Details PubMed

GWAS 2024-01-25

A Genome-Wide Association Study of Prostate Cancer Susceptibility Using Occupational and Environmental Factors as Confounding Factors.

Takeuchi T, Hattori-Kato M et al.

Cureus

Background In addition to genetic predisposition, occupational and environmental factors are importa...

Prostate cancer

714

Participants

N/A

Studies

Details PubMed

GWAS 2023-12-05

Prostate cancer genetic risk and associated aggressive disease in men of African ancestry.

Soh PXY, Mmekwa N et al.

Nat Commun

African ancestry is a significant risk factor for prostate cancer and advanced disease. Yet, genetic...

High-risk prostate cancer

664

Participants

N/A

Studies

Details PubMed

GWAS 2023-11-09

Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.

Wang A, Shen J et al.

Nat Genet

The transferability and clinical value of genetic risk scores (GRSs) across populations remain limit...

Prostate cancer

944762

Participants

N/A

Studies

Details PubMed

GWAS 2023-08-23

Androgen receptor binding sites enabling genetic prediction of mortality due to prostate cancer in cancer-free subjects.

Ito S, Liu X et al.

Nat Commun

Prostate cancer (PrCa) is the second most common cancer worldwide in males. While strongly warranted...

Prostate cancer

98181

Participants

N/A

Studies

Details PubMed

GWAS 2023-08-09

Germline genetic variants associated with somatic TMPRSS2:ERG fusion status in prostate cancer: a genome-wide association study.

Ma C, Wang X et al.

Cancer Epidemiol Biomarkers Prev

The prostate cancer subtype defined by the presence of TMPRSS2:ERG has been shown to be molecularly ...

Prostate cancer (TMPRSS2:ERG(+) vs TMPRSS2:ERG(-))

786

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Efficient candidate drug target discovery through proteogenomics in a Scottish cohort.

Kuliesius J, Timmers PRHJ et al.

Commun Biol

E3 ubiquitin-protein ligase pellino homolog 1 protein levels (SomaScan ID:10758-2)

2025-08-29

Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups.

Hoffmann TJ, Graff RE et al.

Nat Genet

Prostate-specific antigen levels

2025-02-10

Heterogeneous genetic architectures of prostate cancer susceptibility in sub-Saharan Africa.

Janivara R, Chen WC et al.

Nat Genet

Prostate cancer

2024-10-02

Unravelling genetic architecture of circulatory amino acid levels, and their effect on risk of complex disorders.

Abar L, Zuber V et al.

NAR Genom Bioinform

Alanine levels

2024-05-06

An early-onset specific polygenic risk score optimizes age-based risk estimate and stratification of prostate cancer: population-based cohort study.

Cheng Y, Wu L et al.

J Transl Med

Prostate cancer

2024-04-17

New role of fat-free mass in cancer risk linked with genetic predisposition.

Harris BHL, Di Giovannantonio M et al.

Sci Rep

Postmenopausal breast cancer

2024-03-27

Genetic susceptibility to prostate cancer in Taiwan: A genome-wide association study.

Bau DT, Tsai CW et al.

Mol Carcinog

Prostate cancer

2024-02-23

A Genome-Wide Association Study of Prostate Cancer Susceptibility Using Occupational and Environmental Factors as Confounding Factors.

Takeuchi T, Hattori-Kato M et al.

Cureus

Prostate cancer

2024-01-25

Prostate cancer genetic risk and associated aggressive disease in men of African ancestry.

Soh PXY, Mmekwa N et al.

Nat Commun

High-risk prostate cancer

2023-12-05

Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.

Wang A, Shen J et al.

Nat Genet

Prostate cancer

2023-11-09

Androgen receptor binding sites enabling genetic prediction of mortality due to prostate cancer in cancer-free subjects.

Ito S, Liu X et al.

Nat Commun

Prostate cancer

2023-08-23

Germline genetic variants associated with somatic TMPRSS2:ERG fusion status in prostate cancer: a genome-wide association study.

Ma C, Wang X et al.

Cancer Epidemiol Biomarkers Prev

Prostate cancer (TMPRSS2:ERG(+) vs TMPRSS2:ERG(-))

2023-08-09