Active: Ulcerative colitis Clear all

GWAS 2025-01-01

Joint analysis of genome-wide cross-trait and multi-omics reveals molecular mechanisms of inflammatory bowel disease and nominates its novel therapeutic genes.

Zhu Z, Wei R et al.

FASEB J

Inflammatory bowel disease (IBD) with the two predominant endophenotypes-Crohn's disease (CD) and ul...

Inflammatory bowel disease (MTAG)

82967

Participants

N/A

Studies

Details PubMed

GWAS 2024-10-22

Genetic insight into the relationship between inflammatory bowel disease and <i>Clostridioides difficile</i> infection.

Cushing-Damm KC, Chen Y et al.

mSphere

Patients with inflammatory bowel disease (IBD) are at increased risk of Clostridioides difficile inf...

Clostridioides difficle infection

677823

Participants

N/A

Studies

Details PubMed

GWAS 2023-08-10

Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets.

Zhao JH, Stacey D et al.

Nat Immunol

Circulating proteins have important functions in inflammation and a broad range of diseases. To iden...

Eukaryotic translation initiation factor 4E-binding protein 1 levels

Replicated

16321

Participants

N/A

Studies

Details PubMed

GWAS 2023-05-08

Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries.

Liu Z, Liu R et al.

Nat Genet

Inflammatory bowel diseases (IBDs) are chronic disorders of the gastrointestinal tract with the foll...

Inflammatory bowel disease

398668

Participants

N/A

Studies

Details PubMed

GWAS 2022-09-26

Case-case genome-wide association analysis identifying genetic loci with divergent effects on Crohn's disease and ulcerative colitis.

Jung S, Kim Y et al.

Hum Mol Genet

Crohn's disease (CD) and ulcerative colitis (UC), two major subtypes of inflammatory bowel disease, ...

Crohn's disease vs ulcerative colitis

Replicated

5925

Participants

N/A

Studies

Details PubMed

GWAS 2022-03-01

Local genetic variation of inflammatory bowel disease in Basque population and its effect in risk prediction.

Garcia-Etxebarria K, Merino O et al.

Sci Rep

Inflammatory bowel disease (IBD) is characterised by chronic inflammation of the gastrointestinal tr...

Inflammatory bowel disease

1433

Participants

N/A

Studies

Details PubMed

GWAS 2021-09-30

A cross-population atlas of genetic associations for 220 human phenotypes.

Sakaue S, Kanai M et al.

Nat Genet

Current genome-wide association studies do not yet capture sufficient diversity in populations and s...

Ulcerative colitis

178689

Participants

N/A

Studies

Details PubMed

GWAS 2021-02-17

Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease.

Somineni HK, Nagpal S et al.

Am J Hum Genet

Whether or not populations diverge with respect to the genetic contribution to risk of specific comp...

Inflammatory bowel disease

3418

Participants

N/A

Studies

Details PubMed

GWAS 2021-01-18

Large-scale association analyses identify host factors influencing human gut microbiome composition.

Kurilshikov A, Medina-Gomez C et al.

Nat Genet

To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium curated ...

Gut microbiota presence (genus Anaerostipes id.1991)

18340

Participants

N/A

Studies

Details PubMed

GWAS 2021-01-17

Contribution of a European-Prevalent Variant near CD83 and an East Asian-Prevalent Variant near IL17RB to Herpes Zoster Risk in Tofacitinib Treatment: Results of Genome-Wide Association Study Meta-Analyses.

Bing N, Zhou H et al.

Arthritis Rheumatol

Objective: Tofacitinib is an oral JAK inhibitor for the treatment of rheumatoid arthritis (RA), psor...

Response to tofacitinib treatment in rheumatoid arthritis (herpes zoster)(time to event)

2903

Participants

N/A

Studies

Details PubMed

GWAS 2020-02-19

Genetic Analysis of Ulcerative Colitis in Japanese Individuals Using Population-specific SNP Array.

Okamoto D, Kawai Y et al.

Inflamm Bowel Dis

To clarify the genetic background of ulcerative colitis (UC) in the Japanese population, we conducte...

Ulcerative colitis

Replicated

4057

Participants

N/A

Studies

Details PubMed

GWAS 2018-08-01

An Intergenic Variant rs9268877 Between HLA-DRA and HLA-DRB Contributes to the Clinical Course and Long-term Outcome of Ulcerative Colitis.

Lee HS, Yang SK et al.

J Crohns Colitis

Background and aims: The genetic contribution to the prognosis of ulcerative colitis [UC] is poorly ...

Poor prognosis in Crohn's disease

Replicated

854

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Joint analysis of genome-wide cross-trait and multi-omics reveals molecular mechanisms of inflammatory bowel disease and nominates its novel therapeutic genes.

Zhu Z, Wei R et al.

FASEB J

Inflammatory bowel disease (MTAG)

2025-01-01

Genetic insight into the relationship between inflammatory bowel disease and <i>Clostridioides difficile</i> infection.

Cushing-Damm KC, Chen Y et al.

mSphere

Clostridioides difficle infection

2024-10-22

Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets.

Zhao JH, Stacey D et al.

Nat Immunol

Eukaryotic translation initiation factor 4E-binding protein 1 levels

2023-08-10

Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries.

Liu Z, Liu R et al.

Nat Genet

Inflammatory bowel disease

2023-05-08

Case-case genome-wide association analysis identifying genetic loci with divergent effects on Crohn's disease and ulcerative colitis.

Jung S, Kim Y et al.

Hum Mol Genet

Crohn's disease vs ulcerative colitis

2022-09-26

Local genetic variation of inflammatory bowel disease in Basque population and its effect in risk prediction.

Garcia-Etxebarria K, Merino O et al.

Sci Rep

Inflammatory bowel disease

2022-03-01

A cross-population atlas of genetic associations for 220 human phenotypes.

Sakaue S, Kanai M et al.

Nat Genet

Ulcerative colitis

2021-09-30

Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease.

Somineni HK, Nagpal S et al.

Am J Hum Genet

Inflammatory bowel disease

2021-02-17

Large-scale association analyses identify host factors influencing human gut microbiome composition.

Kurilshikov A, Medina-Gomez C et al.

Nat Genet

Gut microbiota presence (genus Anaerostipes id.1991)

2021-01-18

Contribution of a European-Prevalent Variant near CD83 and an East Asian-Prevalent Variant near IL17RB to Herpes Zoster Risk in Tofacitinib Treatment: Results of Genome-Wide Association Study Meta-Analyses.

Bing N, Zhou H et al.

Arthritis Rheumatol

Response to tofacitinib treatment in rheumatoid arthritis (herpes zoster)(time to event)

2021-01-17

Genetic Analysis of Ulcerative Colitis in Japanese Individuals Using Population-specific SNP Array.

Okamoto D, Kawai Y et al.

Inflamm Bowel Dis

Ulcerative colitis

2020-02-19

An Intergenic Variant rs9268877 Between HLA-DRA and HLA-DRB Contributes to the Clinical Course and Long-term Outcome of Ulcerative Colitis.

Lee HS, Yang SK et al.

J Crohns Colitis

Poor prognosis in Crohn's disease

2018-08-01