Active: Am J Hum Genet Clear all

GWAS 2025-08-28

Evaluating multi-ancestry genome-wide association methods: Statistical power, population structure, and practical implications.

Dias JA, Chen T et al.

Am J Hum Genet

The increasing availability of diverse biobanks has enabled multi-ancestry genome-wide association s...

Asthma

324822

Participants

N/A

Studies

Details PubMed

GWAS 2025-08-13

Genetic analysis in African ancestry populations reveals genetic contributors to lung cancer susceptibility.

Betti MJ, Jaworski J et al.

Am J Hum Genet

Striking disparities in lung cancer exist, with Black/African American individuals disproportionatel...

Lung cancer

6490

Participants

N/A

Studies

Details PubMed

GWAS 2025-03-07

The contribution of coding variants to the heritability of multiple cancer types using UK Biobank whole-exome sequencing data.

Wilcox N, Tyrer JP et al.

Am J Hum Genet

Genome-wide association studies have been highly successful at identifying common variants associate...

Pancreatic cancer (Gene-based burden)

419307

Participants

N/A

Studies

Details PubMed

GWAS 2024-09-05

Genetic modifiers of body mass index in individuals with cystic fibrosis.

Ling H, Raraigh KS et al.

Am J Hum Genet

To identify modifier loci underlying variation in body mass index (BMI) in persons with cystic fibro...

Body mass index in cystic fibrosis

4393

Participants

N/A

Studies

Details PubMed

GWAS 2024-05-15

Oral and non-oral lichen planus show genetic heterogeneity and differential risk for autoimmune disease and oral cancer.

Reeve MP, Vehviläinen M et al.

Am J Hum Genet

Lichen planus (LP) is a T-cell-mediated inflammatory disease affecting squamous epithelia in many pa...

ICD10 L43: Lichen planus

412090

Participants

N/A

Studies

Details PubMed

GWAS 2024-05-07

Integrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions.

Dareng EO, Coetzee SG et al.

Am J Hum Genet

To identify credible causal risk variants (CCVs) associated with different histotypes of epithelial ...

Non-mucinous epithelial ovarian cancer

129118

Participants

N/A

Studies

Details PubMed

GWAS 2024-01-01

Genetic determinants of IgG antibody response to COVID-19 vaccination.

Bian S, Guo X et al.

Am J Hum Genet

Human humoral immune responses to SARS-CoV-2 vaccines exhibit substantial inter-individual variabili...

Anti-SARS-CoV-2 spike protein IgG seronegativity after first dose of COVID-19 vaccine

54066

Participants

N/A

Studies

Details PubMed

GWAS 2023-08-29

Genome-wide association study of esophageal squamous cell cancer identifies shared and distinct risk variants in African and Chinese populations.

Chen WC, Brandenburg JT et al.

Am J Hum Genet

Esophageal squamous cell carcinoma (ESCC) has a high disease burden in sub-Saharan Africa and has a ...

Esophageal squamous cell carcinoma

4903

Participants

N/A

Studies

Details PubMed

GWAS 2023-08-24

Response to anti-IL17 therapy in inflammatory disease is not strongly impacted by genetic background.

Zhang C, Shestopaloff K et al.

Am J Hum Genet

Response to the anti-IL17 monoclonal antibody secukinumab is heterogeneous, and not all participants...

Erythrocyte sedimentation rate x secukinumab treatment interaction in ankylosing spondylitis

754

Participants

N/A

Studies

Details PubMed

GWAS 2023-08-01

Genetic insights into the age-specific biological mechanisms governing human ovarian aging.

Ojavee SE, Darrous L et al.

Am J Hum Genet

There is currently little evidence that the genetic basis of human phenotype varies significantly ac...

Age at natural menopause

Replicated

243506

Participants

N/A

Studies

Details PubMed

GWAS 2023-05-04

Genome-wide aggregated trans-effects on risk of type 1 diabetes: A test of the "omnigenic" sparse effector hypothesis of complex trait genetics.

Iakovliev A, McGurnaghan SJ et al.

Am J Hum Genet

The "omnigenic" hypothesis postulates that the polygenic effects of common SNPs on a typical complex...

Type 1 diabetes

12461

Participants

N/A

Studies

Details PubMed

GWAS 2022-10-01

Pleiotropic modifiers of age-related diabetes and neonatal intestinal obstruction in cystic fibrosis.

Aksit MA, Ling H et al.

Am J Hum Genet

Individuals with cystic fibrosis (CF) develop complications of the gastrointestinal tract influenced...

Meconium ileus in cystic fibrosis

4489

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Evaluating multi-ancestry genome-wide association methods: Statistical power, population structure, and practical implications.

Dias JA, Chen T et al.

Am J Hum Genet

Asthma

2025-08-28

Genetic analysis in African ancestry populations reveals genetic contributors to lung cancer susceptibility.

Betti MJ, Jaworski J et al.

Am J Hum Genet

Lung cancer

2025-08-13

The contribution of coding variants to the heritability of multiple cancer types using UK Biobank whole-exome sequencing data.

Wilcox N, Tyrer JP et al.

Am J Hum Genet

Pancreatic cancer (Gene-based burden)

2025-03-07

Genetic modifiers of body mass index in individuals with cystic fibrosis.

Ling H, Raraigh KS et al.

Am J Hum Genet

Body mass index in cystic fibrosis

2024-09-05

Oral and non-oral lichen planus show genetic heterogeneity and differential risk for autoimmune disease and oral cancer.

Reeve MP, Vehviläinen M et al.

Am J Hum Genet

ICD10 L43: Lichen planus

2024-05-15

Integrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions.

Dareng EO, Coetzee SG et al.

Am J Hum Genet

Non-mucinous epithelial ovarian cancer

2024-05-07

Genetic determinants of IgG antibody response to COVID-19 vaccination.

Bian S, Guo X et al.

Am J Hum Genet

Anti-SARS-CoV-2 spike protein IgG seronegativity after first dose of COVID-19 vaccine

2024-01-01

Genome-wide association study of esophageal squamous cell cancer identifies shared and distinct risk variants in African and Chinese populations.

Chen WC, Brandenburg JT et al.

Am J Hum Genet

Esophageal squamous cell carcinoma

2023-08-29

Response to anti-IL17 therapy in inflammatory disease is not strongly impacted by genetic background.

Zhang C, Shestopaloff K et al.

Am J Hum Genet

Erythrocyte sedimentation rate x secukinumab treatment interaction in ankylosing spondylitis

2023-08-24

Genetic insights into the age-specific biological mechanisms governing human ovarian aging.

Ojavee SE, Darrous L et al.

Am J Hum Genet

Age at natural menopause

2023-08-01

Genome-wide aggregated trans-effects on risk of type 1 diabetes: A test of the "omnigenic" sparse effector hypothesis of complex trait genetics.

Iakovliev A, McGurnaghan SJ et al.

Am J Hum Genet

Type 1 diabetes

2023-05-04

Pleiotropic modifiers of age-related diabetes and neonatal intestinal obstruction in cystic fibrosis.

Aksit MA, Ling H et al.

Am J Hum Genet

Meconium ileus in cystic fibrosis

2022-10-01