Active: Br J Haematol Clear all

GWAS 2025-08-31

European-based polygenic risk score and genome-wide association study of B-cell non-Hodgkin lymphoma subtypes in Israeli Jews and Palestinian Arabs.

Kleinstern G, Robinson DP et al.

Br J Haematol

Among individuals of European Ancestry (EA), genome-wide association studies (GWAS) have identified ...

Diffuse large B-cell non-Hodgkin lymphoma

1120

Participants

N/A

Studies

Details PubMed

GWAS 2023-01-05

Genome-wide association study of early ischaemic stroke risk in Brazilian individuals with sickle cell disease implicates ADAMTS2 and CDK18 and uncovers novel loci.

Earley EJ

Br J Haematol

Ischemic stroke in HbSS sickle cell disease

Replicated

1861

Participants

N/A

Studies

Details PubMed

GWAS 2022-08-12

Prominence of NUDT15 genetic variation associated with 6-mercaptopurine tolerance in a genome-wide association study of Japanese children with acute lymphoblastic leukaemia.

Tanaka Y, Urayama KY et al.

Br J Haematol

Inherited genetic variation is associated with 6-mercaptopurine (6-MP) dose reduction and frequent t...

6-mercaptopurine dose in acute lymphoblastic leukaemia

Replicated

279

Participants

N/A

Studies

Details PubMed

GWAS 2020-03-30

Novel exomic rare variants associated with venous thrombosis.

Deguchi H, Shukla M et al.

Br J Haematol

Exomic rare variant polymorphisms (c. 300 000) were analysed in the Scripps Venous Thrombosis (VTE) ...

Venous thromboembolism

315

Participants

N/A

Studies

Details PubMed

GWAS 2018-11-18

Genetic predisposition to PEG-asparaginase hypersensitivity in children treated according to NOPHO ALL2008.

Højfeldt SG, Wolthers BO et al.

Br J Haematol

Asparaginase is essential in childhood acute lymphoblastic leukaemia (ALL) treatment, however hypers...

PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia

831

Participants

N/A

Studies

Details PubMed

GWAS 2013-10-01

Genome-wide genotype-based risk model for survival in acute myeloid leukaemia patients with normal karyotype.

Choi H, Jung C et al.

Br J Haematol

Single nucleotide polymorphisms (SNP) are inter-individual genetic variations that could explain int...

Acute myeloid leukemia

Replicated

247

Participants

N/A

Studies

Details PubMed

GWAS 2013-02-14

Genetic determinants of haemolysis in sickle cell anaemia.

Milton JN, Rooks H et al.

Br J Haematol

Haemolytic anaemia is variable among patients with sickle cell anaemia and can be estimated by retic...

Sickle cell anemia (haemolysis)

Replicated

2075

Participants

N/A

Studies

Details PubMed

GWAS 2012-10-09

HbA2 levels in normal adults are influenced by two distinct genetic mechanisms.

Menzel S, Garner C et al.

Br J Haematol

Using a genome-wide association study, we found that common inter-individual differences in haemoglo...

HbA2 levels

Replicated

4038

Participants

N/A

Studies

Details PubMed

GWAS 2012-01-16

Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project.

Oudot-Mellakh T, Cohen W et al.

Br J Haematol

Deficiencies of antithrombin (AT), protein C (PC) and protein S (PS) or an impaired PC anticoagulant...

Hemostatic factors and hematological phenotypes

951

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

European-based polygenic risk score and genome-wide association study of B-cell non-Hodgkin lymphoma subtypes in Israeli Jews and Palestinian Arabs.

Kleinstern G, Robinson DP et al.

Br J Haematol

Diffuse large B-cell non-Hodgkin lymphoma

2025-08-31

Genome-wide association study of early ischaemic stroke risk in Brazilian individuals with sickle cell disease implicates ADAMTS2 and CDK18 and uncovers novel loci.

Earley EJ

Br J Haematol

Ischemic stroke in HbSS sickle cell disease

2023-01-05

Prominence of NUDT15 genetic variation associated with 6-mercaptopurine tolerance in a genome-wide association study of Japanese children with acute lymphoblastic leukaemia.

Tanaka Y, Urayama KY et al.

Br J Haematol

6-mercaptopurine dose in acute lymphoblastic leukaemia

2022-08-12

Novel exomic rare variants associated with venous thrombosis.

Deguchi H, Shukla M et al.

Br J Haematol

Venous thromboembolism

2020-03-30

Genetic predisposition to PEG-asparaginase hypersensitivity in children treated according to NOPHO ALL2008.

Højfeldt SG, Wolthers BO et al.

Br J Haematol

PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia

2018-11-18

Genome-wide genotype-based risk model for survival in acute myeloid leukaemia patients with normal karyotype.

Choi H, Jung C et al.

Br J Haematol

Acute myeloid leukemia

2013-10-01

Genetic determinants of haemolysis in sickle cell anaemia.

Milton JN, Rooks H et al.

Br J Haematol

Sickle cell anemia (haemolysis)

2013-02-14

HbA2 levels in normal adults are influenced by two distinct genetic mechanisms.

Menzel S, Garner C et al.

Br J Haematol

HbA2 levels

2012-10-09

Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project.

Oudot-Mellakh T, Cohen W et al.

Br J Haematol

Hemostatic factors and hematological phenotypes

2012-01-16