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GWAS 2024-03-20

Genetic evidence for T-wave area from 12-lead electrocardiograms to monitor cardiovascular diseases in patients taking diabetes medications.

Qi M, Zhang H et al.

Hum Genet

Aims Many studies indicated use of diabetes medications can influence the electrocardiogram (ECG), w...

R peak area in lead V2

42340

Participants

N/A

Studies

Details PubMed

GWAS 2024-01-05

Genome-wide association and Mendelian randomization analysis provide insights into the shared genetic architecture between high-dimensional electrocardiographic features and ischemic heart disease.

Wang X, Qi M et al.

Hum Genet

Observational studies have revealed that ischemic heart disease (IHD) has a unique manifestation on ...

12-lead ECG morphology phenotype

41960

Participants

N/A

Studies

Details PubMed

GWAS 2023-07-06

Genomic characterisation of the overlap of endometriosis with 76 comorbidities identifies pleiotropic and causal mechanisms underlying disease risk.

McGrath IM, Montgomery GW et al.

Hum Genet

Comorbid conditions can be driven by underlying pleiotropic and causal mechanisms that can provide i...

Endometriosis

281898

Participants

N/A

Studies

Details PubMed

GWAS 2023-04-16

Clinical and genome-wide association analysis of chemoradiation-induced hearing loss in nasopharyngeal carcinoma.

He YQ, Luo LT et al.

Hum Genet

Chemoradiation-induced hearing loss (CRIHL) is one of the most devasting side effects for nasopharyn...

Chemoradiation-induced hearing loss in nasopharyngeal carcinoma

777

Participants

N/A

Studies

Details PubMed

GWAS 2023-03-14

Genome-wide analysis of genetic pleiotropy and causal genes across three age-related ocular disorders.

Yao X, Yang H et al.

Hum Genet

Age-related macular degeneration (AMD), cataract, and glaucoma are leading causes of blindness world...

AMD or cataract or glaucoma (pleiotropy)

818138

Participants

N/A

Studies

Details PubMed

GWAS 2023-02-20

Cross-trait analyses identify shared genetics between migraine, headache, and glycemic traits, and a causal relationship with fasting proinsulin.

Islam MR, Nyholt DR

Hum Genet

The co-occurrence of migraine and glycemic traits has long been reported in observational epidemiolo...

Migraine or 2-hr glucose levels

937810

Participants

N/A

Studies

Details PubMed

GWAS 2021-05-28

Novel loci and mapuche genetic ancestry are associated with pubertal growth traits in Chilean boys.

Vicuña L, Norambuena T et al.

Hum Genet

Puberty is a complex developmental process that varies considerably among individuals and population...

Age at peak height velocity

904

Participants

N/A

Studies

Details PubMed

GWAS 2020-12-31

Deciphering the genetic and epidemiological landscape of mitochondrial DNA abundance.

Hägg S, Jylhävä J et al.

Hum Genet

Mitochondrial (MT) dysfunction is a hallmark of aging and has been associated with most aging-relate...

Mitochondrial DNA levels

295150

Participants

N/A

Studies

Details PubMed

GWAS 2020-09-21

Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality.

Adewuyi EO, Mehta D et al.

Hum Genet

Evidence from observational studies indicates that endometriosis and depression often co-occur. Howe...

Endometriosis or depression (pleiotropy)

609867

Participants

N/A

Studies

Details PubMed

GWAS 2020-09-09

Genome-wide landscape establishes novel association signals for metabolic traits in the Arab population.

Hebbar P, Abubaker JA et al.

Hum Genet

While the Arabian population has a high prevalence of metabolic disorders, it has not been included ...

Height

2732

Participants

N/A

Studies

Details PubMed

GWAS 2020-08-09

The shared genetic architecture of schizophrenia, bipolar disorder and lifespan.

Muntané G, Farré X et al.

Hum Genet

Psychiatric disorders such as Schizophrenia (SCZ) and Bipolar Disorder (BD) represent an evolutionar...

Schizophrenia or parental lifespan (pleiotropy)

555318

Participants

N/A

Studies

Details PubMed

GWAS 2020-07-15

A pooled genome-wide association study identifies pancreatic cancer susceptibility loci on chromosome 19p12 and 19p13.3 in the full-Jewish population.

Streicher SA, Klein AP et al.

Hum Genet

Jews are estimated to be at increased risk of pancreatic cancer compared to non-Jews, but their obse...

Pancreatic cancer

2738

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genetic evidence for T-wave area from 12-lead electrocardiograms to monitor cardiovascular diseases in patients taking diabetes medications.

Qi M, Zhang H et al.

Hum Genet

R peak area in lead V2

2024-03-20

Genome-wide association and Mendelian randomization analysis provide insights into the shared genetic architecture between high-dimensional electrocardiographic features and ischemic heart disease.

Wang X, Qi M et al.

Hum Genet

12-lead ECG morphology phenotype

2024-01-05

Genomic characterisation of the overlap of endometriosis with 76 comorbidities identifies pleiotropic and causal mechanisms underlying disease risk.

McGrath IM, Montgomery GW et al.

Hum Genet

Endometriosis

2023-07-06

Clinical and genome-wide association analysis of chemoradiation-induced hearing loss in nasopharyngeal carcinoma.

He YQ, Luo LT et al.

Hum Genet

Chemoradiation-induced hearing loss in nasopharyngeal carcinoma

2023-04-16

Genome-wide analysis of genetic pleiotropy and causal genes across three age-related ocular disorders.

Yao X, Yang H et al.

Hum Genet

AMD or cataract or glaucoma (pleiotropy)

2023-03-14

Cross-trait analyses identify shared genetics between migraine, headache, and glycemic traits, and a causal relationship with fasting proinsulin.

Islam MR, Nyholt DR

Hum Genet

Migraine or 2-hr glucose levels

2023-02-20

Novel loci and mapuche genetic ancestry are associated with pubertal growth traits in Chilean boys.

Vicuña L, Norambuena T et al.

Hum Genet

Age at peak height velocity

2021-05-28

Deciphering the genetic and epidemiological landscape of mitochondrial DNA abundance.

Hägg S, Jylhävä J et al.

Hum Genet

Mitochondrial DNA levels

2020-12-31

Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality.

Adewuyi EO, Mehta D et al.

Hum Genet

Endometriosis or depression (pleiotropy)

2020-09-21

Genome-wide landscape establishes novel association signals for metabolic traits in the Arab population.

Hebbar P, Abubaker JA et al.

Hum Genet

Height

2020-09-09

The shared genetic architecture of schizophrenia, bipolar disorder and lifespan.

Muntané G, Farré X et al.

Hum Genet

Schizophrenia or parental lifespan (pleiotropy)

2020-08-09

A pooled genome-wide association study identifies pancreatic cancer susceptibility loci on chromosome 19p12 and 19p13.3 in the full-Jewish population.

Streicher SA, Klein AP et al.

Hum Genet

Pancreatic cancer

2020-07-15