Active: Pharmacogenomics J Clear all

GWAS 2023-07-17

HLA-DQA1*05 and upstream variants of PPARGC1B are associated with infliximab persistence in Japanese Crohn's disease patients.

Shimoda F, Naito T et al.

Pharmacogenomics J

Recently, the HLA-DQA1*05 (rs2097432) genetic variation has been reported to be linked to early infl...

Infliximab persistence in Crohn's disease

Participants

N/A

Studies

Details PubMed

GWAS 2023-01-19

Investigating genetic variants for treatment response to selective serotonin reuptake inhibitors in syndromal factors and side effects among patients with depression in Taiwanese Han population.

Huang SS, Chen YT et al.

Pharmacogenomics J

Major depressive disorder (MDD) is associated with high heterogeneity in clinical presentation. In a...

SSRI response to core syndromal factor measured by HAM-D-21 in major depressive disorder

421

Participants

N/A

Studies

Details PubMed

GWAS 2022-06-25

A machine learning model using SNPs obtained from a genome-wide association study predicts the onset of vincristine-induced peripheral neuropathy.

Yamada H, Ohmori R et al.

Pharmacogenomics J

Vincristine treatment may cause peripheral neuropathy. In this study, we identified the genes associ...

Vincristine-induced peripheral neuropathy in cancer

Participants

N/A

Studies

Details PubMed

GWAS 2022-02-11

UGT1A1 genetic variants are associated with increases in bilirubin levels in rheumatoid arthritis patients treated with sarilumab.

Lin N, Damask A et al.

Pharmacogenomics J

Sarilumab is a human monoclonal antibody against interleukin (IL)-6Rα that has been approved for the...

Bilirubin levels in sarilumab-treated rheumatoid arthritis patients

755

Participants

N/A

Studies

Details PubMed

GWAS 2021-06-22

New genetic variants associated with major adverse cardiovascular events in patients with acute coronary syndromes and treated with clopidogrel and aspirin.

Liu X, Xu H et al.

Pharmacogenomics J

Although a few studies have reported the effects of several polymorphisms on major adverse cardiovas...

Major adverse cardiovascular events in response to aspirin and clopidogrel treatment

Replicated

1961

Participants

N/A

Studies

Details PubMed

GWAS 2021-04-06

Genetic variants associated with cardiometabolic abnormalities during treatment with selective serotonin reuptake inhibitors: a genome-wide association study.

Fjukstad KK, Athanasiu L et al.

Pharmacogenomics J

Selective serotonin reuptake inhibitors (SSRIs) are prescribed both to patients with schizophrenia a...

HDL levels x SSRI levels interaction in schizophrenia or bipolar disorder

1180

Participants

N/A

Studies

Details PubMed

GWAS 2020-11-10

Rapid response to the alpha-1 adrenergic agent phenylephrine in the perioperative period is impacted by genomics and ancestry.

Wenric S, Jeff JM et al.

Pharmacogenomics J

The emergence of genomic data in biobanks and health systems offers new ways to derive medically imp...

Rapid response to perioperative phenylephrine (change in mean arterial pressure)

3699

Participants

N/A

Studies

Details PubMed

GWAS 2020-10-03

Genome-wide association study of cardiovascular disease in testicular cancer patients treated with platinum-based chemotherapy.

Steggink LC, Boer H et al.

Pharmacogenomics J

Genetic variation may mediate the increased risk of cardiovascular disease (CVD) in chemotherapy-tre...

cardiovascular disease in testicular cancer treated with platinum-based chemotherapy

375

Participants

N/A

Studies

Details PubMed

GWAS 2020-02-21

Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment.

Rasmussen ER, Hallberg P et al.

Pharmacogenomics J

Angioedema in the mouth or upper airways is a feared adverse reaction to angiotensin-converting enzy...

Angioedema in response to angiotensin-converting enzyme inhibitor and/or angiotensin receptor blocker

Replicated

5063

Participants

N/A

Studies

Details PubMed

GWAS 2019-12-06

Genome-wide meta-analysis of variant-by-diuretic interactions as modulators of lipid traits in persons of European and African ancestry.

de las Fuentes L, Sung YJ et al.

Pharmacogenomics J

Hypertension (HTN) is a significant risk factor for cardiovascular morbidity and mortality. Metaboli...

LDL cholesterol levels x loop diuretics use interaction

38834

Participants

N/A

Studies

Details PubMed

GWAS 2019-05-02

Genetic association between CD96 locus and immunogenicity to anti-TNF therapy in Crohn's disease.

Aterido A, Palau N et al.

Pharmacogenomics J

The production of antibodies to anti-tumor necrosis factor alpha (TNF) agents is one of the main cau...

Anti-adalimumab antibody production in response to treatment in Crohn's disease

Replicated

150

Participants

N/A

Studies

Details PubMed

GWAS 2019-04-11

Identification of SAMD9L as a susceptibility locus for intravenous immunoglobulin resistance in Kawasaki disease by genome-wide association analysis.

Kim JJ, Yun SW et al.

Pharmacogenomics J

Kawasaki disease (KD) is a systemic vasculitis affecting infants and children; it manifests as fever...

Response to intravenous immunoglobulin treatment in Kawasaki disease

Replicated

1538

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

HLA-DQA1*05 and upstream variants of PPARGC1B are associated with infliximab persistence in Japanese Crohn's disease patients.

Shimoda F, Naito T et al.

Pharmacogenomics J

Infliximab persistence in Crohn's disease

2023-07-17

Investigating genetic variants for treatment response to selective serotonin reuptake inhibitors in syndromal factors and side effects among patients with depression in Taiwanese Han population.

Huang SS, Chen YT et al.

Pharmacogenomics J

SSRI response to core syndromal factor measured by HAM-D-21 in major depressive disorder

2023-01-19

A machine learning model using SNPs obtained from a genome-wide association study predicts the onset of vincristine-induced peripheral neuropathy.

Yamada H, Ohmori R et al.

Pharmacogenomics J

Vincristine-induced peripheral neuropathy in cancer

2022-06-25

UGT1A1 genetic variants are associated with increases in bilirubin levels in rheumatoid arthritis patients treated with sarilumab.

Lin N, Damask A et al.

Pharmacogenomics J

Bilirubin levels in sarilumab-treated rheumatoid arthritis patients

2022-02-11

New genetic variants associated with major adverse cardiovascular events in patients with acute coronary syndromes and treated with clopidogrel and aspirin.

Liu X, Xu H et al.

Pharmacogenomics J

Major adverse cardiovascular events in response to aspirin and clopidogrel treatment

2021-06-22

Genetic variants associated with cardiometabolic abnormalities during treatment with selective serotonin reuptake inhibitors: a genome-wide association study.

Fjukstad KK, Athanasiu L et al.

Pharmacogenomics J

HDL levels x SSRI levels interaction in schizophrenia or bipolar disorder

2021-04-06

Rapid response to the alpha-1 adrenergic agent phenylephrine in the perioperative period is impacted by genomics and ancestry.

Wenric S, Jeff JM et al.

Pharmacogenomics J

Rapid response to perioperative phenylephrine (change in mean arterial pressure)

2020-11-10

Genome-wide association study of cardiovascular disease in testicular cancer patients treated with platinum-based chemotherapy.

Steggink LC, Boer H et al.

Pharmacogenomics J

cardiovascular disease in testicular cancer treated with platinum-based chemotherapy

2020-10-03

Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment.

Rasmussen ER, Hallberg P et al.

Pharmacogenomics J

Angioedema in response to angiotensin-converting enzyme inhibitor and/or angiotensin receptor blocker

2020-02-21

Genome-wide meta-analysis of variant-by-diuretic interactions as modulators of lipid traits in persons of European and African ancestry.

de las Fuentes L, Sung YJ et al.

Pharmacogenomics J

LDL cholesterol levels x loop diuretics use interaction

2019-12-06

Genetic association between CD96 locus and immunogenicity to anti-TNF therapy in Crohn's disease.

Aterido A, Palau N et al.

Pharmacogenomics J

Anti-adalimumab antibody production in response to treatment in Crohn's disease

2019-05-02

Identification of SAMD9L as a susceptibility locus for intravenous immunoglobulin resistance in Kawasaki disease by genome-wide association analysis.

Kim JJ, Yun SW et al.

Pharmacogenomics J

Response to intravenous immunoglobulin treatment in Kawasaki disease

2019-04-11