Active: Sci Adv Clear all

GWAS 2026-02-13

Cross-trait genomic modeling reveals the polygenic architecture and systemic impact of MASLD.

Du M

Sci Adv

Metabolic dysfunction-associated steatotic liver disease (MTAG)

122644

Participants

N/A

Studies

Details PubMed

GWAS 2026-01-01

Genome-wide association study reveals genetic architecture and evolution of human retinal pigmentation.

Yuan J

Sci Adv

Grade of retinal pigmentation

50700

Participants

N/A

Studies

Details PubMed

GWAS 2025-06-13

Beyond volume: Unraveling the genetics of human brain geometry.

Primus SA, Hoffstaedter F et al.

Sci Adv

Brain geometry affects brain function. A quantitative encoding of form is provided by the Laplace-Be...

Left accumbens area shape (Laplace-Beltrami spectrum)

Replicated

24823

Participants

N/A

Studies

Details PubMed

GWAS 2025-06-04

Diversity and longitudinal records: Genetic architecture of disease associations and polygenic risk in the Taiwanese Han population.

Liu TY, Lu HF et al.

Sci Adv

We addressed the underrepresentation of non-European populations in genome-wide association studies ...

Acute vascular insufficiency of intestine (PheCode 441.1)

228734

Participants

N/A

Studies

Details PubMed

GWAS 2025-01-24

The X chromosome's influences on the human brain.

Jiang Z, Sullivan PF et al.

Sci Adv

Genes on the X chromosome are extensively expressed in the human brain. However, little is known for...

White matter microstructure (fractional anisotropy) Anterior corona radiata (PC1)

Replicated

38309

Participants

N/A

Studies

Details PubMed

GWAS 2025-01-17

Genome-wide and phenome-wide studies provided insights into brain glymphatic system function and its clinical associations.

Ran L, Fang Y et al.

Sci Adv

We applied an MRI technique diffusion tensor imaging along the perivascular space (DTI-ALPS) for ass...

Anterior diffusion tensor imaging along the perivascular space index

31629

Participants

N/A

Studies

Details PubMed

GWAS 2024-05-29

Two genome-wide interaction loci modify the association of nonsteroidal anti-inflammatory drugs with colorectal cancer.

Drew DA, Kim AE et al.

Sci Adv

Regular, long-term aspirin use may act synergistically with genetic variants, particularly those in ...

Colorectal cancer x regluar aspirin and/or NSAID use interaction (1df)

72667

Participants

N/A

Studies

Details PubMed

GWAS 2024-04-19

Tissue-specific genetic variation suggests distinct molecular pathways between body shape phenotypes and colorectal cancer.

Peruchet-Noray L

Sci Adv

Body shape phenotype PC1

460198

Participants

N/A

Studies

Details PubMed

GWAS 2024-01-26

Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people.

Koyanagi YN, Nakatochi M et al.

Sci Adv

An East Asian-specific variant on aldehyde dehydrogenase 2 (ALDH2 rs671, G>A) is the major geneti...

Daily alcohol intake in rs671 GG genotype

87980

Participants

N/A

Studies

Details PubMed

GWAS 2023-06-09

Sequence variants affecting voice pitch in humans.

Gisladottir RS, Helgason A et al.

Sci Adv

The genetic basis of the human vocal system is largely unknown, as are the sequence variants that gi...

Voice pitch (reading)

12901

Participants

N/A

Studies

Details PubMed

GWAS 2023-04-26

Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity.

Schmidt AF, Bourfiss M et al.

Sci Adv

Dysfunction of either the right or left ventricle can lead to heart failure (HF) and subsequent morb...

Right ventricular end diastolic volume

35941

Participants

N/A

Studies

Details PubMed

GWAS 2023-02-17

Genetic architecture of the white matter connectome of the human brain.

Sha Z, Schijven D et al.

Sci Adv

White matter tracts form the structural basis of large-scale brain networks. We applied brain-wide t...

Node-level brain connectivity (multivariate analysis)

30810

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Cross-trait genomic modeling reveals the polygenic architecture and systemic impact of MASLD.

Du M

Sci Adv

Metabolic dysfunction-associated steatotic liver disease (MTAG)

2026-02-13

Genome-wide association study reveals genetic architecture and evolution of human retinal pigmentation.

Yuan J

Sci Adv

Grade of retinal pigmentation

2026-01-01

Beyond volume: Unraveling the genetics of human brain geometry.

Primus SA, Hoffstaedter F et al.

Sci Adv

Left accumbens area shape (Laplace-Beltrami spectrum)

2025-06-13

Diversity and longitudinal records: Genetic architecture of disease associations and polygenic risk in the Taiwanese Han population.

Liu TY, Lu HF et al.

Sci Adv

Acute vascular insufficiency of intestine (PheCode 441.1)

2025-06-04

The X chromosome's influences on the human brain.

Jiang Z, Sullivan PF et al.

Sci Adv

White matter microstructure (fractional anisotropy) Anterior corona radiata (PC1)

2025-01-24

Genome-wide and phenome-wide studies provided insights into brain glymphatic system function and its clinical associations.

Ran L, Fang Y et al.

Sci Adv

Anterior diffusion tensor imaging along the perivascular space index

2025-01-17

Two genome-wide interaction loci modify the association of nonsteroidal anti-inflammatory drugs with colorectal cancer.

Drew DA, Kim AE et al.

Sci Adv

Colorectal cancer x regluar aspirin and/or NSAID use interaction (1df)

2024-05-29

Tissue-specific genetic variation suggests distinct molecular pathways between body shape phenotypes and colorectal cancer.

Peruchet-Noray L

Sci Adv

Body shape phenotype PC1

2024-04-19

Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people.

Koyanagi YN, Nakatochi M et al.

Sci Adv

Daily alcohol intake in rs671 GG genotype

2024-01-26

Sequence variants affecting voice pitch in humans.

Gisladottir RS, Helgason A et al.

Sci Adv

Voice pitch (reading)

2023-06-09

Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity.

Schmidt AF, Bourfiss M et al.

Sci Adv

Right ventricular end diastolic volume

2023-04-26

Genetic architecture of the white matter connectome of the human brain.

Sha Z, Schijven D et al.

Sci Adv

Node-level brain connectivity (multivariate analysis)

2023-02-17